2008
DOI: 10.2298/jsc0806619g
|View full text |Cite
|
Sign up to set email alerts
|

Synthesis, structural characterization and cytotoxic activity of two new organoruthenium(II) complexes

Abstract: Two new p-cymene ruthenium(II) complexes containing as additional ligands N-methylpiperazine ([(η 6 -p-cymene)RuCl 2 (CH 3 NH(CH 2 ) 4 NH)]PF 6 , complex 1) or vitamin K 3 -thiosemicarbazone ([(η 6 -p-cymene)RuCl 2 (K 3 tsc)], complex 2) were synthesized starting from [(η 6 -p-cymene) 2 RuCl 2 ] 2 and the corresponding ligand. The complexes were characterized by elemental analysis, IR, electronic absorption and NMR spectroscopy. The X-ray crystal structure determination of complex 1 revealed "piano-stool" geom… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
3
1
1

Citation Types

0
6
0

Year Published

2009
2009
2021
2021

Publication Types

Select...
9

Relationship

4
5

Authors

Journals

citations
Cited by 11 publications
(6 citation statements)
references
References 33 publications
0
6
0
Order By: Relevance
“…Examples of ruthenium complexes with piperazine or their derivatives described in the literature are scarce. [21][22][23] Chart 1 Complexes reported in this work; underlined compounds have been characterised by X-ray crystallography.…”
Section: Synthesismentioning
confidence: 99%
“…Examples of ruthenium complexes with piperazine or their derivatives described in the literature are scarce. [21][22][23] Chart 1 Complexes reported in this work; underlined compounds have been characterised by X-ray crystallography.…”
Section: Synthesismentioning
confidence: 99%
“…In spite of the observations of Köpf and coworkers, which discarded alkyl, alkenyl or aryl substituted ansa-titanocene complexes due to their lack of cytotoxicity [65], we have recently reported an increase of the cytotoxicity for titanocene and ansa-titanocene complexes that have pendant alkenyl substituents on the cyclopentadienyl rings [66,67]. Following our research on the synthesis, characterization and cytotoxic properties of metal-based anticancer drugs [68][69][70][71][72][73], we present the synthesis, characterization and the study of the cytotoxicity of different alkenyl and boryl substituted titanocene complexes (Fig. 1) in order to evaluate the influence of these groups on the cytotoxicity of the corresponding complexes.…”
Section: Introductionmentioning
confidence: 97%
“…As many of our recent research is centred on the synthesis, characterization and cytotoxic properties of metal-based anticancer drugs [45][46][47][48][49], and in view of the lack of studies about carboxylate gallium(III) complexes in the context of medicinal chemistry [50], as well as the limited investigations concerning interactions of gallium complexes with aminoacid derivatives [51,52], here, we present the synthesis, characterization, antitumoural activity and evaluation of the mode of cell death induced by novel gallium(III) complexes containing N-phthaloyl derivatives of neutral aminoacids such as glycine and DL-alanine.…”
Section: Introductionmentioning
confidence: 99%