Synthesis, structural characterization and influence on the phagocytic activity of human neutrophils of thiazoline and thiazine derivative ligands and their zinc(II) complexes

Effects of a derivative thiazoline/thiazolidine azine ligand and its cadmium complexes on phagocytic activity by human neutrophils

“…Some coordination compounds, like zinc(II) complex with the organic ligand 2-(3,4-dichlorophenyl)imino-N-(4H-5,6-dihydro-1,3-thiazin-2-yl)tetrahydro-1,3-thiazine [4] and copper(II) and ruthenium(II) complexes of the antifungal drug Ketoconazole [3] improve phagocytosis with respect to organic ligand. In other cases, metal complexes do not affect neutrophils phagocytosis as occur for one zinc(II) complex [4] and some gold(I), copper(II) and ruthenium(II) complexes [3]. Finally, in the case of certain diclofenac transition metal complexes [5] the phagocytosis decreases with respect to the drug.…”

“…Likewise, coordination compounds interfere with in vitro phagocytosis showing either improve, like copper(II) and ruthenium(II) complexes of the antifungal drug Ketoconazole [3] and one zinc(II) complex with the organic ligand 2- (3,4-dichlorophenyl)imino-N-(4H-5,6-dihydro-1,3-thiazin-2-yl)tetrahydro-1,3-thiazine [4], or decrease, as it is the case of certain diclofenac transition metal complexes [5].…”

Domino way toward the synthesis of novel 4-(4-morpholinophenyl)-6-aryl-6H-1,3-thiazin-2-amines under focused microwave irradiation catalyzed by heterogeneous NAHSO4 · SIO2 and their in vitro microbiological evaluation

“…2-Amino-1,3-thiazines and their derivatives are chemically and pharmaceutically interesting entities and are used as antimicrobial agents [9], cannabinoid receptor agonists [10,11], phagocytic mimetics [12], vasopressin receptor antagonists [13], antioxidants [14], analgesic, anti-inflammatory [15], and antifilarial agents [16], metalloprotease inhibitors [17], and antihypertensive agents [18]. The presence of N-C-S linkage is believed to account for the extensive biological activities of the thiazine nucleus.…”

Synthesis, spectral characterization, and in vitro antibacterial and antifungal activities of novel 1,3-thiazine-2-amines comprising morpholine nucleus

“…2-Amino-1,3-thiazines and their derivatives are chemically and pharmaceutically interesting entities, and have been used as antimicrobial agents 1 , as cannabinoid receptor agonists 2 , in the discovery of CB2 receptors 3 , in the phagocytic activity of human neutrophils 4 , as vasopressin receptor antagonists 5 , and have central nervous system (CNS) and antioxidant properties 6 , analgesic and anti-inflammatory activities 7 , antifilarial properties 8 , metalloprotease inhibition activity 9 , and antihypertensive activity 10 . The presence of the N-C-S linkage is believed to account for the extensive biological activities of the thiazine nucleus.…”