Synthesis, structural investigations, XRD, DFT, anticancer and molecular docking study of a series of thiazole based Schiff base metal complexes

Insight into the inhibitory potential of metal complexes supported by (E)-2-morpholino-N-(thiophen-2-ylmethylene)ethanamine: synthesis, structural properties, biological evaluation and docking studies

“…The results are reported as the IC 50 (concentration required to inhibit 50% of cell growth) and compared with the vinblastine standard. 32,33 %Inhibition = 100 − (OD control /OD sample ) × 100…”

Significant Aspects of Heterocyclic Schiff Bases and Their Metal Complexes

“…The discussion pertaining to this chapter will purely be focused on the HSBs and related metal complexes containing at least one heterocyclic unit on either side of the imine group. Quite a few structural representations of HSBs (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15) and some of their complexes (16)(17)(18)(19)(20)(21)(22)(23)(24) are shown in Figure 3.…”

“…However, the complexes 31 and 32 exhibit potential cell killing. Al-Shemary et al have found the possible anticancer activities of triazole-derived Schiff base and its transition metal complexes (Co, Ni, Cu, and Zn) against quite a few human cancerous cell lines, such as HepG2 liver cancer, HCT116 colorectal cancer, A549 lung carcinoma, and MCF-7 breast cancer cell lines, taking doxorubicin as the standard [11]. Of all complexes, when compared to untreated, the Zn(II) complex displayed significant activity for inhibiting the growth of HepG2, HCT116, A549, and MCF7 cell lines by a factor of 88, 70, 75, and 70, respectively.…”

Metal Complexes with Schiff Bases as Antimicrobials and Catalysts

“…The catalytic activity of SBs [3], their corrosion inhibition behavior [4], as well as the action as photosensitizers [5], and fluorescent chemo-sensors tools for the detection of Cu 2+ and Fe 3+ metal ions [6] have been reported. Moreover, numerous biological activities were described in the literature for these compounds [7][8][9], such as antitumoral [10][11][12]; antimicrobial [13]; antimalarial [14]; antioxidant; neuroprotective; antidiabetic; antidepressant [15]; anti-inflammatory [16]; and acetylcholinesterase (AChE)-, butyrylcholinesterase (BChE)- [17][18][19], and carbonic anhydrase-inhibiting [20] ones. Moreover, coatings made of SBs have been shown to improve the bioactivity of materials, suggesting the use of these compounds in medicine [21].…”