Synthesis, structure–activity relationship and crystallographic studies of 3-substituted indolin-2-one RET inhibitors

Design, synthesis and biological evaluation of novel 4-thiazolidinones containing indolin-2-one moiety as potential antitumor agent

“…TLC analysis was carried out on silica gel plates GF254 (Qindao Haiyang Chemical, China). Indolin-2-ones 11ae11f were synthesized in accordance with literature procedures [22,23]. The detailed experimental data of precursors (2, 7, 3ae3h and 8ae8f) are presented in Supplementary information.…”

“…The indolin-2-ones 11ae11f were synthesized from appropriate anilines according to the reported procedures [22,23].…”

Synthesis and Anticancer Activity of Indolin‐2‐one Derivatives Bearing the 4‐Thiazolidinone Moiety

“…The indolin-2-ones 4a-4e were synthesized from corresponding anilines according to the reported procedures [1,2]. Rhodanine-3-acetic acid 1 was synthesized via reaction of the glycine and carbon disulfide under basic conditions followed by ring closure with chloroacetic acid.…”

“…A variety of 3-substituted indolin-2-ones have been utilized as anticancer drugs or drug candidates [1][2][3][4][5]. A representative member of this class is sunitinib (SU11248, Sutent TM ; Pfizer, Inc.) which is currently used in the clinics as a multi-targeting tyrosine kinase inhibitor with antiangiogenic activity (Fig.…”

Synthesis of a new class of antimicrobial agents incorporating the indolin-2-one moiety

“…Since various kinases are involved in the growth of microorganisms and because many oxindoles are kinase inhibitors 6,[12][13][14][15][16] , a variety of 3-substituted indolin-2-ones have been utilized as anticancer drugs or drug candidates [17][18][19][20][21] . A representative member of this class is Sunitinib (SU11248, SutentTM; Pfizer, Cairo, Egypt) which is currently used in the clinics as a multi-targeting tyrosine kinase inhibitor with antiangiogenic activity Figure 1 22,23 .…”