Synthesis, structure–activity relationships, and in vitro antibacterial and antifungal activity evaluations of novel pyrazole carboxylic and dicarboxylic acid derivatives

Crystal structure of N′-(4-nitrobenzylidene)-5-phenyl-1H-pyrazole-3-carbohydrazide, C17H13N5O3

“…Compounds that contain the pyrazole moiety are known to exhibit a wide range of biological properties such as anticancer [1], anticonvulsant [2], antiviral [3], anti-tumor [4], analgesic, sedative [5], antimicrobial [6] and anti-in ammatory activities [7]. In addition, pyrazoles have a wide variety of application in the agrochemical and pharmaceutical industries [8].…”

Synthesis and antimicrobial activity of novel imidazo[1,2-a]pyridinopyrimidine-2,4,6(1H,3H,5H)-triones and thioxopyrimidine-4,6(1H,5H)diones

“…In vitro antimicrobial activity of all the newly synthesized compounds was carried out by using agar well diffusion assay [29,30]. In vitro antibacterial activity was studied against Gram-positive organisms such as Staphylococcus aureus, Streptococcus pyogenes, and Gram-negative bacteria such as Pseudomonas aeruginosa and Klebsiella pneumoniae, and in vitro antifungal activity against fungal strains such as Candida albicans, Fusarium oxysporum, Aspergillus niger, and Aspergillus candidus fungal strains.…”

Anti-pharmacophore Identification and Structure-Activity Relationships for the Inhibition of Cellular Protein and DNA Syntheses by a Series of Thiosemicarbazones and Thiosemicarbazides

“…Electron-conformational method (ECM) [5][6][7][8], known also as electron-topological method (ETM) [2,3,[9][10][11][12], was developed for pharmacophore identification and pharmacophore-based bioactivity prediction. Its objects are two (active and inactive) or more bioactivity sets of a series of molecules.…”