Synthesis, structure and anticancer activity of (η6-benzene) ruthenium(II) complexes containing aroylhydrazone ligands

Half‐sandwiched ruthenium (II) arene complexes with piano stool‐like geometry with the general formula [(p‐cymene)RuClL1] and [(p‐cymene)RuClL2] [where L1 = (Z)‐N′‐((1,3‐diphenyl‐1H‐pyrazol‐4‐yl)methylene)furan‐2‐carbohydrazide and L2 = (Z)‐N′‐((1,3‐diphenyl‐1H‐pyrazol‐4‐yl)methylene)thiophene‐2‐carbohydrazide] were synthesized and characterized. The single crystal X‐ray data revealed that the complexes belong to the same crystal system (monoclinic) with octahedral geometry, where the ruthenium atom is surrounded by hydrazone ligand coordinated through ON atoms, one chloride labile co‐ligand and the remaining three coordination sites covered by an electron cloud of p‐cymene moiety. The interaction between the complexes and DNA/bovine serum albumin (BSA) was evaluated using absorption and emission titration methods showing intercalative modes of interaction. The DNA cleavage ability of the complexes was checked by agarose gel electrophoresis method exhibiting the destruction of DNA duplex arrangement. To understand the interaction between ruthenium complex and DNA/BSA molecule, molecular docking studies were performed. In vitro cytotoxicity of the complexes was examined by the 3‐(4,5‐dimethylthiazol‐2‐yl)‐2,5‐diphenyltetrazolium bromide (MTT) assay on human lung cancer cell line, A549, and found that at lower IC50, cell growth inhibition has occurred. Similarly, the IC50 values of the complexes treated with cancerous cell lines have produced a significant amount of lactase dehydrogenase and nitrite content in the culture medium, which were evaluated as apoptosis‐inducing factors, suggesting that the ruthenium (II) arene hydrazone complexes with pyrazole ligands have promising anticancer activities.

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“…Protons at the p ‐cymene moiety show peaks at δ 5.2–5.8. The remaining peaks at about δ 7.08–7.9 correspond to aromatic protons …”

Section: Resultssupporting

confidence: 56%

Organoruthenium (II) complexes featuring pyrazole‐linked Schiff base ligands: Crystal structure, DNA/BSA interactions, cytotoxicity and molecular docking

Neethu

Eswaran²,

Theetharappan

et al. 2019

Applied Organom Chemis

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“…It is inferred from the results that the complexes notably arrest A549 cell growth. Complex 6 exhibited higher antiproliferation which might be due to the presence of electron-donating nature of methoxy group …”

Section: Resultsmentioning

confidence: 99%

Synthesis and Structure of Arene Ru(II) N^∧O-Chelating Complexes: In Vitro Cytotoxicity and Cancer Cell Death Mechanism

et al. 2020

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“…2e). 15 Abirami et al examined the anticancer action of Ru( ii ) arene hydrazone complexes toward lung carcinoma, breast carcinoma, and liver carcinoma (Fig. 2f).…”

Section: Introductionmentioning

confidence: 99%

New dinuclear arene Ru(ii) benzilbis(furoylhydrazone) complexes: synthesis, structure, and anticancer activity

Monika

Ramesh

2023

New J. Chem.

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Synthesis, structure and anticancer activity of (η6-benzene) ruthenium(II) complexes containing aroylhydrazone ligands

Cited by 26 publications

References 50 publications

Organoruthenium (II) complexes featuring pyrazole‐linked Schiff base ligands: Crystal structure, DNA/BSA interactions, cytotoxicity and molecular docking

Organoruthenium (II) complexes featuring pyrazole‐linked Schiff base ligands: Crystal structure, DNA/BSA interactions, cytotoxicity and molecular docking

Synthesis and Structure of Arene Ru(II) N^∧O-Chelating Complexes: In Vitro Cytotoxicity and Cancer Cell Death Mechanism

New dinuclear arene Ru(ii) benzilbis(furoylhydrazone) complexes: synthesis, structure, and anticancer activity

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Synthesis, structure and anticancer activity of (η6-benzene) ruthenium(II) complexes containing aroylhydrazone ligands

Cited by 26 publications

References 50 publications

Organoruthenium (II) complexes featuring pyrazole‐linked Schiff base ligands: Crystal structure, DNA/BSA interactions, cytotoxicity and molecular docking

Organoruthenium (II) complexes featuring pyrazole‐linked Schiff base ligands: Crystal structure, DNA/BSA interactions, cytotoxicity and molecular docking

Synthesis and Structure of Arene Ru(II) N∧O-Chelating Complexes: In Vitro Cytotoxicity and Cancer Cell Death Mechanism

New dinuclear arene Ru(ii) benzilbis(furoylhydrazone) complexes: synthesis, structure, and anticancer activity

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Product

Resources

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Synthesis and Structure of Arene Ru(II) N^∧O-Chelating Complexes: In Vitro Cytotoxicity and Cancer Cell Death Mechanism