Synthesis, structure, and biological activity of bis(benzimidazole)amino thio- and selenoether nickel complexes

Muñoz-Patiño, Natalia; Sánchez-Eguía, Brenda N.; Araiza‐Olivera, Daniela; Flores‐Álamo, Marcos; Hernández‐Ortega, Simón; Martı́nez-Otero, Diego; Castillo, Iván

doi:10.1016/j.jinorgbio.2020.111198

Cited by 15 publications

(16 citation statements)

References 41 publications

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“…Other researchers have shown that benzimidazole family members can affect different cancer cells by different anti-proliferative and anticancer mechanisms, some of which are discussed here (13,14).…”

Section: Discussionmentioning

confidence: 96%

Cytotoxic Effects of Flubendazole in Human Lung Cancer Cell Line A549

Hoveizi

Jahromi

2020

Jentashapir J Cell Mol Biol

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Background: The development of effective anticancer drugs is a significant health issue. Previous studies showed that members of the benzimidazole family have anticancer effects on several cancers Objectives: The present study investigated the cytotoxic effect of flubendazole on A549 human lung cancer cells. Methods: The A549 cells were treated with flubendazole at 1, 2, 5, and 10 µM concentrations for three days. Cell viability was measured by the MTT assay and Acridine orange staining. Also, the expressions of P62 and Beclin -1 were analyzed by qRT-PCR analysis. Results: Cell viability of A549 cells, in a concentration-dependent manner, showed significant differences between the treatment and control groups, and the IC50 value was determined to be 2 µM. Also, flubendazole reduced the expression of P62 and increased the expression of Beclin 1 in treated cells. Conclusions: Flubendazole induces cell death in A549 cells in a dose and time-dependent manner and can offer new factors in lung cancer therapeutic strategies.

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Section: Discussionmentioning

confidence: 96%

Cytotoxic Effects of Flubendazole in Human Lung Cancer Cell Line A549

Hoveizi

Jahromi

2020

Jentashapir J Cell Mol Biol

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“…), 6.92-6.90 (m, 2Harom. ), 6.86-6.09 (br, s, 2H, NH 2 ); 13 C NMR (100 MHz, DMSO-d 6 ) δ (ppm): 159.30, 159.17, 119.93; elemental analysis for C 8 H 9 N 5 (calcd/ found): C, 54.85/54.92; H, 5.18/5.00; N, 39.96/40.11.…”

Section: Synthesis Of the N-1hbenzimidazol-2-ylguanidine (Bg) As Ligandmentioning

confidence: 99%

Antibacterial, antifungal, anti‐inflammatory evaluation, molecular docking, and density functional theory exploration of 2‐(1H‐benzimidazol‐2‐yl)guanidine mixed‐ligand complexes: Synthesis and characterization

Abd El‐Lateef,

Khalaf,

Amer

et al. 2023

Applied Organom Chemis

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The aim of the present framework is to synthesize and characterize new cobalt(II) (C1), nickel(II) (C2), and copper(II) (C3) mixed‐ligand complexes incorporating bioactive 8‐hydroxyquinoline moiety, with synthesized 2‐(1H‐benzimidazol‐2‐yl)guanidine (BG) ligand, for investigating their antibacterial, antifungal, and anti‐inflammatory potential. The metal complexes structure had been elucidated by the use of a wide range of methods, including elemental analysis, Fourier transform infrared (FT‐IR), mass spectra, UV–vis spectra, magnetic susceptibility, thermogravimetric (TG) analysis, and the molar ratio technique of stoichiometry analysis. The resulted metal complexes were found to have octahedral structures in molar ratio of M:BG:Qu as 1:1:2. Density functional theory (DFT) had been used to determine the optimal molecular structure and quantum chemical properties of each material. After that, we looked into the metal complexes' anti‐inflammatory and antibacterial properties by testing them in vitro. The disc diffusion test showed that the metal complexes were far more potent against bacteria/fungi than the original ligands. The egg albumin denaturation technique showed that the metal complexes were more potent anti‐inflammatory candidates than the free ligands and comparable with the standard reference. Molecular docking analysis against 5JQ9, 6CLV, and cyclooxygenase‐2 (COX‐2; 5IKT) confirmed the bioactivity behavior of the metal complexes. C3 has the greatest binding affinity among the metal complexes tested. These findings proposed that the metal complexes could form the basis of future antibiotics and anti‐inflammatory candidates. Finally, the in vitro activities were reviewed in relation to the DFT and molecular docking data.

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“…Additionally, a number of nickel (II) complexes showed antibacterial 7 , 9 , antifungal 10 , 11 , anti-leishmanic 12 , anti-inflammatory 13 and antioxidant 14 , 15 properties. Attention was also paid to the anti-proliferative effect of Ni (II) complexes in relation to different cell lines 2 , 5 , 16 . Importantly, due to its properties, nickel is widely used in industry.…”

Section: Introductionmentioning

confidence: 99%

Nickel ions influence the transepithelial sodium transport in the trachea, intestine and skin

Hołyńska-Iwan

Sobiesiak

Kowalczyk³

et al. 2023

Sci Rep

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Measurements of transepithelial potential and resistance in tissue and organ model systems enable the evaluation of the Ni2+ effect on the epithelial sodium channels, aquaporin 3, and the sodium–potassium pump in the epithelial cells. The aim of the presented study was to assess the immediate and prolonged effect of nickel ions on the transport of sodium ions in tissues exposed to direct contact with nickel, including airways, digestive tract and the skin. The influence of 0.1 mM nickel solution was performed on the trachea (n = 34), intestine (n = 44), and skin (n = 51) samples descended from 16 New Zealand albino rabbits. The electrophysiological parameters were measured in a modified Ussing chamber in stationary conditions and during a 15-s mechanical-chemical stimulation. A statistically significant decrease in the electric resistance values and the smallest range of the measured potential were observed for the Ni-treated trachea specimens. The use of nickel solution did not affect the sodium transport in the intestine epithelium. The skin fragments showed altered sodium ion transport, as demonstrated by the lower range and intensity of the measured potential. The gastrointestinal tract seems to be an organ best adapted to contact with nickel ions. In airways, nickel ions most likely enter epithelial cells and the space between them, modifying proteins and the airway surface liquid. The skin turned out to be the most sensitive tissue to the intensification of sodium ion transport through nickel ions.

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Synthesis, structure, and biological activity of bis(benzimidazole)amino thio- and selenoether nickel complexes

Cited by 15 publications

References 41 publications

Cytotoxic Effects of Flubendazole in Human Lung Cancer Cell Line A549

Cytotoxic Effects of Flubendazole in Human Lung Cancer Cell Line A549

Antibacterial, antifungal, anti‐inflammatory evaluation, molecular docking, and density functional theory exploration of 2‐(1H‐benzimidazol‐2‐yl)guanidine mixed‐ligand complexes: Synthesis and characterization

Nickel ions influence the transepithelial sodium transport in the trachea, intestine and skin

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