Synthesis, structure and cytotoxic activity of mixed-valent Cu(I)/Cu(II) salt containing a pyrazolone derivative as ligand

Mosoarca, Elena Maria; Pantenburg, Ingo; Tudose, Ramona; Meyer, Gerd; Popa, Nicolæ; Han, Adelina; Alexandrova, Radostina; Kalfin, Reni; Linert, Wolfgang; Costişor, Otilia

doi:10.1016/j.ica.2011.02.035

Cited by 8 publications

(6 citation statements)

References 39 publications

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“…The resulting 50% growth inhibitory concentration (IC 50 ) values are summarized in Table S6 in the ESI † and graphically depicted in Fig. S17 -4) is comparable to that of previously reported copper complexes [77][78][79] comprising N-((1H-imidazole-2-yl)methyl)-2-(pyridine-2-yl)ethanamine/meclofenamic acid/N,N 0 -tetra(4-antipyrylmethyl)-1,2-diaminoethane against A549 and MCF7 cancer cell lines. 80 Copper complexes of the bis-b-diketone-type ligand (the curcumine derivative) have been used as fluorescent probes, but they did not show significant cytotoxic activity against A549, HeLa and MCF-7 cell lines.…”

Section: Cytotoxicitysupporting

confidence: 84%

Structural diversity in aroylthiourea copper complexes – formation and biological evaluation of [Cu(i)(μ-S)SCl]₂, cis-Cu(ii)S₂O₂, trans-Cu(ii)S₂O₂and Cu(i)S₃cores

et al. 2016

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Section: Cytotoxicitysupporting

confidence: 84%

Structural diversity in aroylthiourea copper complexes – formation and biological evaluation of [Cu(i)(μ-S)SCl]₂, cis-Cu(ii)S₂O₂, trans-Cu(ii)S₂O₂and Cu(i)S₃cores

et al. 2016

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“…286 In contrast to the ligand, the corresponding complex 101 decreased the viability of both cultured tumor (MCF-7, A549, 8MGBA, Hep G2) and nontumor (MDBK, Balb/c 3T3) cell lines in a time-and concentration-dependent manner. 286…”

Section: O-donor Systemsmentioning

confidence: 97%

“…Starting from antipyrine , N , N ′-tetra(4-antipyrylmethyl)-1,2-diaminoethane ( L 101a ) and (2,3-dimethyl-1-phenyl-3-pyrazolin-5-one) the N , N ′-bis(4-antipyrylmethyl)piperazine ( L 101b ) were prepared, and the mixed-valent compound [Cu II ( L 101a )][Cu I (NCS) 2 Cl](DMF) 2 , 101 (Figure b), was synthesized and structurally characterized . In contrast to the ligand, the corresponding complex 101 decreased the viability of both cultured tumor (MCF-7, A549, 8MGBA, Hep G2) and nontumor (MDBK, Balb/c 3T3) cell lines in a time- and concentration-dependent manner …”

Section: Copper Complexes As Anticancer Agentsmentioning

confidence: 99%

Advances in Copper Complexes as Anticancer Agents

et al. 2013

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Copper is a transition metal that can exist in oxidized (Cu(II)) and reduced (Cu(I)) states. This allows it to participate in redox and catalytic chemistry, making it a suitable cofactor for a diverse range of enzymes and molecules. Copper complexes have been investigated for their therapeutic or diagnostic potential showing effectiveness in cancer treatment due to their cytotoxic action on tumour cells. In this review, the most remarkable achievements in the design and development of copper(I, II) complexes as antitumor agents are discussed. Special emphasis has been focused on the identification of structure-activity relationships for the different classes of complexes. Up to now, despite the enormous efforts in synthesizing different classes of copper complexes, very few data concerning the molecular basis of the mechanisms underlying their antitumor activity are available. The current overview, collecting the most significant strategies adopted in the last four years to design promising anticancer copper(I,II) compounds, aims to provide a useful reference for researchers working in this field

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“…(Table 3) and (Figure 9). It is important to mention that the copper(II) complex presented herein showed better growth inhibitory effect than the previously reported copper complexes [57][58][59][60]. The cytotoxic properties of this new Cu(II) complex can be attributed to the extended planar structure induced by the chelation of the quinoline ligand to the copper ion in the complex.…”

Section: Dna Binding Studiesmentioning

confidence: 60%

Synthesis, characterization and biological studies of a novel Cu(II) Schiff base complex

Thirunavukkarasu

Sparkes

Natarajan

et al. 2018

Inorganica Chimica Acta

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A Cu(II) complex was obtained from the reaction of 4-(diethylamino)-3-quinolin-3-yliminomethyl-2-phenol with [CuCl2(PPh3)2]. The ligand coordinated to the metal ion in a monobasic bidentate fashion. The molecular structure of the complex has been confirmed by single crystal X-ray diffraction. Both the ligand and complex were characterized by various spectroscopic techniques. Using the UV-visible and fluorescence spectroscopic studies, the binding interactions of the compounds with CT-DNA and bovine serum albumin protein were evaluated. The results indicated that the compounds are efficient DNA/protein binders. The cytotoxicity of the ligand and complex against A549 (lung cancer) and MCF7 (breast cancer) cell lines was also investigated in vitro conditions using the MTT assay method which showed significant anticancer activity.

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Synthesis, structure and cytotoxic activity of mixed-valent Cu(I)/Cu(II) salt containing a pyrazolone derivative as ligand

Cited by 8 publications

References 39 publications

Structural diversity in aroylthiourea copper complexes – formation and biological evaluation of [Cu(i)(μ-S)SCl]₂, cis-Cu(ii)S₂O₂, trans-Cu(ii)S₂O₂and Cu(i)S₃cores

Structural diversity in aroylthiourea copper complexes – formation and biological evaluation of [Cu(i)(μ-S)SCl]₂, cis-Cu(ii)S₂O₂, trans-Cu(ii)S₂O₂and Cu(i)S₃cores

Advances in Copper Complexes as Anticancer Agents

Synthesis, characterization and biological studies of a novel Cu(II) Schiff base complex

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Synthesis, structure and cytotoxic activity of mixed-valent Cu(I)/Cu(II) salt containing a pyrazolone derivative as ligand

Cited by 8 publications

References 39 publications

Structural diversity in aroylthiourea copper complexes – formation and biological evaluation of [Cu(i)(μ-S)SCl]2, cis-Cu(ii)S2O2, trans-Cu(ii)S2O2and Cu(i)S3cores

Structural diversity in aroylthiourea copper complexes – formation and biological evaluation of [Cu(i)(μ-S)SCl]2, cis-Cu(ii)S2O2, trans-Cu(ii)S2O2and Cu(i)S3cores

Advances in Copper Complexes as Anticancer Agents

Synthesis, characterization and biological studies of a novel Cu(II) Schiff base complex

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Structural diversity in aroylthiourea copper complexes – formation and biological evaluation of [Cu(i)(μ-S)SCl]₂, cis-Cu(ii)S₂O₂, trans-Cu(ii)S₂O₂and Cu(i)S₃cores

Structural diversity in aroylthiourea copper complexes – formation and biological evaluation of [Cu(i)(μ-S)SCl]₂, cis-Cu(ii)S₂O₂, trans-Cu(ii)S₂O₂and Cu(i)S₃cores