Synthesis, Structure, and Spectroscopic Properties of Bismuth Citrate Compounds and the Bismuth-Containing Ulcer-Healing Agent Colloidal Bismuth Subcitrate (CBS). 4. Crystal Structure and Solution Behavior of a Unique Dodecanuclear Cluster (NH4)12[Bi12O8(cit)8](H2O)10

Asato, Eiji; Katsura, Kosho; Mikuriya, Masahiro; Turpeinen, Urho; Mutikainen, Ilpo; Reedijk, J.

doi:10.1021/ic00113a028

Cited by 74 publications

(55 citation statements)

References 1 publication

Supporting

Mentioning

Contrasting

Order By: Relevance

“…[44] In contrast, the hexanuclear {Bi 6 } unit A is part of a wide variety of molecular bismuth-oxo clusters. [23,31,32,[41][42][43][44] It has been suggested that in aqueous solution hexanuclear cations of the type [Bi 6 O 4 + x (OH) 4Àx ] (6Àx) + are predominantly found at pH < 3 at low concentrations (0.1 m). With increasing pH, nonanuclear species are formed.…”

Section: Discussionmentioning

confidence: 99%

“…The hexanuclear unit A is the most common structural motif reported for bismuth-oxo compounds and is realised in bismuth-oxo(hydroxy) nitrates, [41] bismuth-oxo(hydroxy) perchlorates, [42] bismuth-oxo alkoxides, [23,31,32] and bismuth-oxo carboxylates. [43,44] [Bi 18 (m 3 -O) 12 3 ] in toluene at 4 8C that had been exposed to air moisture. Compounds 7 and 8 both crystallise in the space group P1 with one formula unit per unit cell.…”

mentioning

confidence: 99%

See 1 more Smart Citation

Polynuclear Bismuth‐Oxo Clusters: Insight into the Formation Process of a Metal Oxide

Mehring

Mansfeld

Paalasmaa

et al. 2006

Chemistry A European J

View full text Add to dashboard Cite

The reaction of the bismuth silanolates [Bi(OSiR2R')3] (R = R' = Me, Et, iPr; R = Me, R' = tBu) with water has been studied. Partial hydrolysis gave polynuclear bismuth-oxo clusters whereas amorphous bismuth-oxo(hydroxy) silanolates were obtained when an excess of water was used in the hydrolysis reaction. The metathesis reaction of BiCl3 with NaOSiMe3 provided mixtures of heterobimetallic silanolates. The molecular structures of [Bi18Na4O20(OSiMe3)18] (2), [Bi33NaO38(OSiMe3)24].3 C7H8 (3.3 C7H8), [Bi50Na2O64(OH)2(OSiMe3)22].2 C7H8.2H2O (4.2 C7H8.2 H2O), [Bi4O2(OSiEt3)8] (5), [Bi9O7(OSiMe3)13].0.5 C7H8 (6. 0.5C7H8), [Bi18O18(OSiMe3)18)].2C7H8 (7. 2C7H8) and [Bi20O18(OSiMe3)24].3C7H8 (8.3C7H8) are presented and compared with the solid-state structures of [Bi22O26(OSiMe2tBu)14] (9) and beta-Bi2O3. Compound 2 crystallises in the triclinic space group P1 with the lattice constants a = 17.0337(9), b = 19.5750(14), c = 26.6799(16) A, alpha = 72.691(4), beta = 73.113(4) and gamma = 70.985(4) degrees ; compound 3.3C7H8 crystallises in the monoclinic space group P2(1)/n with the lattice constants a = 20.488(4), b = 22.539(5), c = 26.154(5) A and beta = 100.79(3) degrees ; compound 4.2C7H82 H2O crystallises in the monoclinic space group P2(1)/n with the lattice constants a = 20.0518(12), b = 24.1010(15), c = 27.4976(14) A and beta = 103.973(3) degrees ; compound 5 crystallises in the monoclinic space group P2(1)/c with the lattice constants a = 25.256(5), b = 15.372(3), c = 21.306(4) A and beta = 113.96(3) degrees ; compound 6.0.5C7H8 crystallises in the triclinic space group P1 with the lattice constants a = 15.1916(9), b = 15.2439(13), c = 22.487(5) A, alpha = 79.686(3), beta = 74.540(5) and gamma = 66.020(4) degrees ; compound 7.2C7H8 crystallises in the triclinic space group P1 with the lattice constants a = 14.8295(12), b = 16.1523(13), c = 18.4166(17) A, alpha = 75.960(4), beta = 79.112(4) and gamma = 63.789(4) degrees ; and compound 8.3C7H8 crystallises in the triclinic space group P1 with the lattice constants a = 17.2915(14), b = 18.383(2), c = 18.4014(18) A, alpha = 95.120(5), beta = 115.995(5) and gamma = 106.813(5) degrees . The molecular structures of the bismuth-rich compounds are related to the CaF2-type structure. Formally, the hexanuclear [Bi6O8]2+ fragment might be described as the central building unit, which is composed of bismuth atoms placed at the vertices of an octahedron and oxygen atoms capping the trigonal faces. Depending on the reaction conditions and the identity of R, the thermal decomposition of the hydrolysis products [Bi(n)O(l)(OH)(m-)(OSiR3)(3n-(2l-m))] gives alpha-Bi2O3, beta-Bi2O3, Bi12SiO20 or Bi4Si3O12.

show abstract

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

Polynuclear Bismuth‐Oxo Clusters: Insight into the Formation Process of a Metal Oxide

Mehring

Mansfeld

Paalasmaa

et al. 2006

Chemistry A European J

View full text Add to dashboard Cite

show abstract

“…Bismuth compounds have been used in medicine for more than 200 years for a variety of gastrointestinal disorders (12,13). There is particular interest in bismuth(III) citrate solubilized by ammonium and potassium hydroxide, which forms the basis of the colloidal bismuth subcitrate present, for example, in the drugs Telen ® (Byk Gulden) and De-Nol ® (Gist Brocade) (14,15). Recently a new adduct of ranitidine with bismuth citrate (Glaxo Wellcome plc), which combines the antisecretory action of ranitidine with mucosal protectant and bactericidal properties of bismuth(III), has been granted a product license in the UK (16,17).…”

mentioning

confidence: 99%

Unexpectedly Strong Binding of a Large Metal Ion (Bi3+) to Human Serum Transferrin

Sadler

Sun

1996

Journal of Biological Chemistry

109

View full text Add to dashboard Cite

Large metal ions (>0.9 Å ionic radius) have previously been found to bind only weakly to human serum transferrin (hTF, 80 kDa), presumably because the interdomain cleft cannot close around the metal and synergistic anion. Surprisingly, therefore, we report that Bi 3؉ (ionic radius 1.03 Å), a metal ion widely used in anti-ulcer drugs, binds strongly to both the N-and C-lobes with log K 1 * ‫؍‬ 19.42 and log K 2 * ‫؍‬ 18.58 (10 mM Hepes, 5 mM bicarbonate, 310 K). The uptake of Bi 3؉ by apo-hTF from bismuth citrate complexes is very slow (hours), whereas that from bismuth nitrilotriacetate is rapid (minutes). Evidence from absorption and NMR spectroscopy is presented to show that Bi 3؉ binds to the specific Fe 3؉ binding sites along with carbonate as the synergistic anion. Under the conditions used, preferential binding of Bi 3؉to the C-lobe of hTF is observed. Linear free energy relationships show that there is a strong correlation between the strength of binding of Bi 3؉ and Fe 3؉ to a wide variety of ligands which include transferrin. Therefore we conclude that the strength of metal ion binding to transferrin is determined more by the ligand donor set than by the size of the ion.

show abstract

“…Another type of bismuth drug is based on bismuth citrate complexes such as colloidal bismuth subcitrate (CBS, De-Nol; Gist Brocades and Yamanouchi), and ranitidine bismuth citrate (RBC, Tritec and Pylorid, GSK), which is used worldwide to treat various gastrointestinal diseases, caused by the H. pylori infection [15][16][17][18]. Both X-ray analysis and structural modeling suggest that the dimeric units of bismuth citrate ([Bi 2 (cit) 2 ] 2À , Figure 3.2b) may form the negative charged polymeric skeletons in both CBS and RBC, and aggregate to a type of 'hybrid' metal organic framework containing regular meshes with the 'encapsulated' NH 4 þ and K þ (in CBS) or ranitidine (in RBC) [19,20]. Ranitidine bismuth citrate is believed to be more potent in the treatment of gastrointestinal disorders since it combines the activity of ranitidine, which reduces the excretion of gastric acid and bismuth citrate, which protects the mucous membrane of the stomach and inhibits H. pylori colonization.…”

Section: Bismuth In Medicinementioning

confidence: 99%

Biological Chemistry of Antimony and Bismuth

Yang

Sun

2010

Biological Chemistry of Arsenic, Antimony and Bismuth

View full text Add to dashboard Cite

Synthesis, Structure, and Spectroscopic Properties of Bismuth Citrate Compounds and the Bismuth-Containing Ulcer-Healing Agent Colloidal Bismuth Subcitrate (CBS). 4. Crystal Structure and Solution Behavior of a Unique Dodecanuclear Cluster (NH4)12[Bi12O8(cit)8](H2O)10

Cited by 74 publications

References 1 publication

Polynuclear Bismuth‐Oxo Clusters: Insight into the Formation Process of a Metal Oxide

Polynuclear Bismuth‐Oxo Clusters: Insight into the Formation Process of a Metal Oxide

Unexpectedly Strong Binding of a Large Metal Ion (Bi3+) to Human Serum Transferrin

Biological Chemistry of Antimony and Bismuth

Contact Info

Product

Resources

About