Synthesis, structure elucidation, biological activity, enzyme inhibition and molecular docking studies of new Schiff bases based on 5-nitroisatin-thiocarbohydrazone

Yakan, Hasan; Omer, Hiba-H. S.; Buruk, Osman; Çakmak, Şükriye; Marah, Sarmad; Veyisoglu, Aysel; Muğlu, Halit; Özen, Tevfik; Kütük, Halil

doi:10.1016/j.molstruc.2022.134799

Cited by 12 publications

(3 citation statements)

References 56 publications

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“…The frequency values of these molecules were in agreement with those reported for similar compounds. 40–44…”

Section: Resultsmentioning

confidence: 99%

“…The frequency values of these molecules were in agreement with those reported for similar compounds. [40][41][42][43][44] In the 1 H-NMR spectra, all the compounds showed a broad singlet (bs) in the range of 10.76-8.09 ppm for the characteristic aromatic NH protons (Ar-NH-) and bis(carbothioamide) NH protons (-CQS-NH-NH-CQS-). In the 13 C-NMR spectrum for compounds 3a-f, the characteristic signal of the -CQS functional group appeared in the range of 181.84-181.27 ppm, while for some derivatives (3g-l) these values also appeared in the range of 162-152 ppm.…”

Section: Chemistrymentioning

confidence: 99%

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Novel asymmetric biscarbothioamides as Alzheimer's disease associated cholinesterase inhibitors: synthesis, biological activity, and molecular docking studies

Muğlu,

Yakan,

Erdoğan

et al. 2024

New J. Chem.

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“…The frequency values of these molecules were in agreement with those reported for similar compounds. 40–44…”

Section: Resultsmentioning

confidence: 99%

Section: Chemistrymentioning

confidence: 99%

Novel asymmetric biscarbothioamides as Alzheimer's disease associated cholinesterase inhibitors: synthesis, biological activity, and molecular docking studies

Muğlu,

Yakan,

Erdoğan

et al. 2024

New J. Chem.

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“…Many Schiff bases and their transition metal complexes have been investigated for their enzyme inhibitory activities. Significant results have been obtained [8].…”

Section: Introductionmentioning

confidence: 99%

A Novel Ni(II) Complex: Synthesis, Spectral and Biological Activity Determination Studies

2023

Proceeding Book of 3rd International Conference on Scientific and Academic Research ICSAR 2023

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A new Ni(II) metal complex of the ligand ((E) methyl 6-benzyl-2-(4-(benzoxy)benzylideneamino)-4, 5,6,7-tetrahydrothieno[2,3-c]pyridine-3-carboxylate), derived from (methyl 2-amino-6-benzyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-3-carboxylate) and 4benzoxybenzaldehyde, has been obtained. Standard spectroscopic techniques were used to elucidate the structural features of the ligand and its nickel (II) complex (elemental analysis, Fourier transform infrared (FT-IR) spectra, 1 H-NMR (proton nuclear magnetic resonance), elemental analysis, molar conductance, UV-Vis ( ultraviolet-visible) spectra, magnetic susceptibility, LC-Mass spectrometry, and TGA (thermogravimetric analysis). The analytical data showed that the Ni(II) complex is located in the ligand: metal ratio (1:1). Spectral studies revealed that the ligand bonds bidentate to the Ni metal ion via the nitrogen atom of the CH=N (azomethine) group and the oxygen atom of the C=O (carbonyl) group. A distorted octahedral structure can be suggested for the Ni(II) complex from electronic spectrum data and magnetic susceptibility values. The in vitro antioxidant and enzyme inhibition activities of Ni(II) complex were investigated. Acetylcholineesterase enzyme inhibition potential of the synthesized Ni(II) complex was found to be close to the standard tacrine compound. The Ni(II) complex was evaluated for its in vitro antioxidant activity according to the DPPH (1,1-Diphenyl-2-picrylhydrazyl) free radical scavenging activity and CUPRAC (cupric ions reducing capacity) in vitro bioanalytical methods. The synthesized Ni(II) complex showed effective antioxidant activity according to the both CUPRAC and DPPH method.

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Synthesis, characterization, and bioactivity of Cu(II), Fe(II), Co(II), Ni(II), and Mn(II) complexes with benzilmonoximethiocarbohydrazide-O-methoxybenzaldehyde: experimental and computational insights

Singh,

Bagul,

Tufail

et al. 2024

Biometals

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Synthesis, structure elucidation, biological activity, enzyme inhibition and molecular docking studies of new Schiff bases based on 5-nitroisatin-thiocarbohydrazone

Cited by 12 publications

References 56 publications

Novel asymmetric biscarbothioamides as Alzheimer's disease associated cholinesterase inhibitors: synthesis, biological activity, and molecular docking studies

Novel asymmetric biscarbothioamides as Alzheimer's disease associated cholinesterase inhibitors: synthesis, biological activity, and molecular docking studies

A Novel Ni(II) Complex: Synthesis, Spectral and Biological Activity Determination Studies

Synthesis, characterization, and bioactivity of Cu(II), Fe(II), Co(II), Ni(II), and Mn(II) complexes with benzilmonoximethiocarbohydrazide-O-methoxybenzaldehyde: experimental and computational insights

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