Synthesis-temperature-regulated multi-enzyme-mimicking activities of ceria nanozymes

Abstract

Ceria (CeO2) nanozymes have drawn much attention in recent years due to their unique physiochemical properties and excellent biocompatibility. It is therefore very important to establish a simple and robust...

New facets of nanozyme activity of ceria: lipo- and phospholipoperoxidase-like behaviour of CeO2 nanoparticles

“…The highly crystalline nature of cerium oxide is consistent with recently reported study of citrate-stabilised ceria nanoparticles. 49 …”

“…For example, Liu et al showed that, especially for the peroxidase mimicking activity, smaller particles do not always exhibit higher catalytic activity. 49 …”

Nanostructured Ceria: Biomolecular Templates and (Bio)applications

“…Interestingly, changing the temperature of preparation of Ce NPs allowed the modulation of their mimicking properties of multiple enzymes, namely superoxide dismutase (SOD), catalase (CAT), oxidase (OXD), peroxidase (POD), alkaline phosphatase (ALP) enzymes, as well as their ability to scavenge the 2,2-diphenyl-1-picrylhydrazyl (DPPH) free radical. In particular, the NPs with the highest level of antioxidant activity provided cells with cytoprotection against aging-and H 2 O 2 -induced oxidative damage; contrarily, those with pro-oxidant activity were proposed as candidates to induce cancer cell death [113]. The POD-like activity can be boosted by doping the CeO 2 with several first-row transition metals (i.e., Mn, Fe, Co, Ni, and Cu), with maximal effect noted for Mn, followed by Co [114].…”

Potentiality of Nanoenzymes for Cancer Treatment and Other Diseases: Current Status and Future Challenges

“…For example, the bonds of nucleotides are hydrolyzed by nucleosidase. The phosphatase enzyme helps in the catalysis of phosphate cleavage from the molecules [24].…”

“…Over the past few years, scientists have made an extraordinary attempt in developing artificial enzymes for various types of applications. Consider the examples that the chemical complexes based on porphyrin [16,17], hematin [18], cyclodextrin [19], hemin [20,21], and the specially designed biomolecules proteins successively imitate the function of the naturally occurring enzymes [22,23].The intrinsic limitations of the natural enzymes such as low stability, high cost, and storage difficulty have led to the introduction of artificial enzymes that imitate the activity of the naturally occurring enzymes [24]. As another sort of promising artificial enzyme, nanozymes have demonstrated a wide range of uses because of their evident favorable circumstances, including low cost, high stability, the large surface area for functionalization, high catalytic activity, and tuneable activity [25].…”