Synthesis, transformations, and pharmacological properties of thienopyridines (review)

Thienopyridines: synthesis, properties, and biological activity

“…Earlier data on biological activi ties were summarized in the review. 14 As in the case of the above described isomeric struc tures, the thieno[3,2 c]pyridine system can be con structed by two radically different pathways, viz., either by the pyridine ring construction starting from substituted thiophene or by annelation of the thiophene ring to the The strategy O assumes the C(7)-C(7a) ring forma tion in the key step of construction of a bicyclic system. The synthesis of the simplest thieno[3,2 c]pyridine 250 in low yield (<10%), which was described for the first time in 1953, 157 provides an example of this approach.…”

“…Information on this problem is lacking in the review, 14 where considerable attention was given to the pharmacological aspect of the use of thienopyridine derivatives. The anticonvulsive activity of substituted pyrido[3´,2´:4,5]thieno [3,2 b]pyridine, which has low toxicity, was documented.…”

“…134 Ear lier data on the biological activities of thieno[2,3 c]pyri dines and related structures were summarized in the review. 14 The majority of methods for the synthesis of thie no[2, 3 c]pyridines and related fused structures can be ten tatively divided into two groups based on the construction of the pyridine or thiophene ring, respectively.…”

A novel and efficient synthesis of diamino derivatives of pyrano[3,4-c]pyridines

“…Examples of such compounds are the derivatives of pyranopyridines. 1 Among the isomeric pyranopyridines the most studied are alkaloids of the pyrano [3,4-c]pyridine line, which are extracted from plants and have universal biological action. Thus, gentianine possesses hypotensive, anti-inflammatory, 2,3 anticonvulsive, 4 antipsychotic, 5 antiulcer 6 and antimalarial 7 activities.…”

Synthesis of 3-Unsubstituted 4-Aryl-4,7-Dihydrothieno[2,3-b]Pyridine-2,5-Dicarboxylates / 3-Neaizvietotu 4-Aril-4,7-Dihidrotiēno[2,3-B]Piridīn-2,5-Dikarbonskābes Esteru Sintēze

“…They are useful for multiple pharmacological applications and indicate theoretical interest as fused heterocycles due to π-electron rich thiophene and π-electron deficient pyridine ring [1][2][3].…”