Synthesis, X-ray crystal structure and cytotoxicity studies of zinc(II) and cadmium(II) iodide complexes with antipyrine

Rukk, N. S.; Кузьмина, Л. Г.; Albov, Dmitry V.; Шамсиев, Р. С.; Mudretsova, S. N.; Давыдова, Г. А.; Ретивов, В. М.; Волков, П. А.; Кравченко, В. В.; Apryshko, G. N.; Стрелецкий, А. Н.; Skryabina, A. Yu.; Mironova, Elena A.; Zamalyutin, V. V.

doi:10.1016/j.poly.2015.09.011

Cited by 20 publications

(7 citation statements)

References 26 publications

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“…Supplementary 1 depicts FT‐IR spectra of H‐DMABTS ligand and its Cd (II) phosphor complex. The FT‐IR spectrum of the Cd (II) phosphor complex shows the disappearance of characteristic spectral band of υ(N‐H) of thiosemicarbazone ligand at 3249 cm −1 . Also, the appearing a new band of υ(C=N) at 1525 cm −1 suggested the coordination via the thiolate form by deprotonation of N‐H proton during the tautomerisation process .…”

Section: Resultsmentioning

confidence: 99%

“…In addition, thiosemicarbazones are an important class of N, S donor ligands, because of their characteristic chemical, biological and medicinal properties including antibacterial, antioxidant, DNA‐binding, antimalarial, antiproliferative, anticancer and antitumor . From above mention, development of new cadmium‐thiosemicarbazone complexes comprises a productive field of investigation considering their relevance in biological systems, sensors and photoluminescence applications …”

Section: Introductionmentioning

confidence: 99%

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Synthesis and Fundamental Characterization of Diverse Properties of Biocompatible Cd (II) Phosphor Complex for Cytotoxic Activity and Latent Fingerprint Detection

Fouad

2020

Applied Organom Chemis

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The development of biocompatible fluorescent materials based on CdII (d10) systems for cytotoxic application and latent fingerprint detection under UV illumination has not yet been studied that thoroughly. In this sense, this work presents production of novel and dual nature pure Cd (II) phosphor complex based on ρ‐dimethylaminobenzaldehyde thiosemicarbazone ligand (H‐DMABTS). The structural characterization confirms that the ligand which acts as monoanionic bidentate through NS donor sites, forming mononuclear complex formulates as: [Cd (DMABTS)2(C2H5OH)2] where, DMABTS = anionic form of ρ‐dimethylaminobenzaldehyde thiosemicarbazone. TEM analysis shows that Cd (II) complex has sheet like shape in micro scale. Moreover, the Cd (II) complex was dispersed into silica host. Photoluminescence emission and lifetime of H‐DMABTS ligand, Cd (II) complex and Cd (II) complex dispersied into silica were measured. Cd (II) complex is intensive luminescent with impressive visual emission under UV excitation. All fluorescent materials were tested for their in vitro cytotoxicity against HepG‐2 cell line. The Cd (II) phosphor complex shows higher activity (IC50 = 0.005 μM) than other prepared materials and different standard antitumor drugs. Furthermore, the Cd (II) phosphor complex has a lower toxicity value (LD50 = 130 mg/Kg) relative to the standard cis‐platin (LD50 = 13.5 mg/Kg). Moreover, latent prints details, including their characteristic three levels, have been clearly identified from various forensic substrates (non‐porous, semi‐porous, porous) using Cd (II) phosphor complex.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Synthesis and Fundamental Characterization of Diverse Properties of Biocompatible Cd (II) Phosphor Complex for Cytotoxic Activity and Latent Fingerprint Detection

Fouad

2020

Applied Organom Chemis

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“…This might be achieved by cotargeting cellular sites and components, and reprogramming the molecular and biochemical pathways of MnCl 2 -stimulated TNBC cells. The inhibitory activity of Cd-containing compounds on viability and growth of normal and neoplastic cells and the mitigatory effect provided by Zn-containing molecules have been reported in the literature [46,47,48]. Taking the limited treatment options against TNBC into account, the specific anticancer modulatory property of CdCl 2 towards MDA-MB231 cells here reported looks promising and deserves a more detailed biological characterization of the involved intracellular targets aimed to the possible molecular modeling of specific antineoplastic agents with improved effectiveness towards the inhibition of the spreading of malignant breast cancer.…”

Section: Discussionmentioning

confidence: 99%

Effect of Manganese Chloride and of Cotreatment with Cadmium Chloride on the In Vitro Proliferative, Motile, and Invasive Behavior of MDA-MB231 Breast Cancer Cells

Luparello¹

2019

Molecules

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We examined the dose–response effect of MnCl2 on the proliferative behavior of triple-negative breast cancer MDA-M231 cells vs. immortalized HB2 cells from breast epithelium taken as nontumoral counterparts. We also tested the effect of MnCl2 on tumor cell invasiveness in vitro by evaluating the relative invasion indexes through Boyden chamber assays. Moreover, we checked whether cotreatment with both MnCl2 and CdCl2 could modify the observed biological response by MDA-MB231 cells. Our results show a promotional impact of MnCl2 on cell proliferation, with 5 µM concentration inducing the more pronounced increase after 96-h exposure, which is not shared by HB2 cells. Exposure to 5 µM MnCl2 induced also an elevation of the relative invasion index of cancer cells. The Mn-mediated stimulatory effects were counteracted by cotreatment with CdCl2. These data support the concept that human exposure to high environmental concentrations of Mn may increase the risk of carcinogenesis and metastasis by prompting the expansion and dissemination of triple-negative breast cancer cells. On the other hand, the Mn-counteracting anticancer property of Cd looks promising and deserves a more detailed characterization of the involved intracellular targets aimed to the molecular modeling of specific antineoplastic agents against malignant breast cancer spreading.

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“…Ligands used for preparation of Cd complexes can be classified as: thiosemicarbazones [16,[18][19][20][21][22][23][24], selenosemicarbazones [25][26][27], hydrazones [16,[27][28][29][30][31][32][33][34][35][36], hydrazides [38,39], diimines [40], amides [41,42], aminoacids [43,44], heterocycles [44][45][46][47][48][49][50][51][52][53][54][55][56], macrocycles [58][59][60], drugs [61][62][63][64], scorpionates [65], natural products …”

Section: Introductionmentioning

confidence: 99%

A novel binuclear hydrazone-based Cd(II) complex is a strong pro-apoptotic inducer with significant activity against 2D and 3D pancreatic cancer stem cells

Bjelogrlić

Todorović

Cvijetić

et al. 2019

Journal of Inorganic Biochemistry

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A novel binuclear Cd complex (1) with hydrazone-based ligand was prepared and characterized by spectroscopy and single crystal X-ray diffraction techniques. Complex 1 reveals a strong pro-apoptotic activity in both human, mammary adenocarcinoma cells (MCF-7) and pancreatic AsPC-1 cancer stem cells (CSCs). While apoptosis undergoes mostly caspase-independent, 1 stimulates the activation of intrinsic pathway with noteworthy down regulation of caspase-8 activity in respect to non-treated controls. Distribution of cells over mitotic division indicates that 1 caused DNA damage in both cell lines, which is confirmed in DNA interaction studies. Compared to 1, cisplatin (CDDP) does not achieve cell death in 2D cultured AsPC-1 cells, while induces different pattern of cell cycle changes and caspase activation in 2D cultured MCF-7 cells, implying that these two compounds do not share similar mechanism of action. Additionally, 1 acts as a powerful inducer of mitochondrial superoxide production with dissipated trans-membrane potential in the majority of the treated cells already after 6 h of incubation. On 3D tumors, 1 displays a superior activity against CSC model, and at 100 μM induces disintegration of spheroids within 2 days of incubation. Fluorescence spectroscopy, along with molecular docking show that compound 1 binds to the minor groove of DNA. Compound 1 binds to the human serum albumin (HSA) showing that the HSA can effectively transport and store 1 in the human body. Thus, our current study strongly supports further investigations on antitumor activity of 1 as a drug candidate for the treatment of highly resistant pancreatic cancer.

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Synthesis, X-ray crystal structure and cytotoxicity studies of zinc(II) and cadmium(II) iodide complexes with antipyrine

Cited by 20 publications

References 26 publications

Synthesis and Fundamental Characterization of Diverse Properties of Biocompatible Cd (II) Phosphor Complex for Cytotoxic Activity and Latent Fingerprint Detection

Synthesis and Fundamental Characterization of Diverse Properties of Biocompatible Cd (II) Phosphor Complex for Cytotoxic Activity and Latent Fingerprint Detection

Effect of Manganese Chloride and of Cotreatment with Cadmium Chloride on the In Vitro Proliferative, Motile, and Invasive Behavior of MDA-MB231 Breast Cancer Cells

A novel binuclear hydrazone-based Cd(II) complex is a strong pro-apoptotic inducer with significant activity against 2D and 3D pancreatic cancer stem cells

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