Synthesis, X-Ray diffraction, theoretical and anti-bacterial studies of bis-thiourea secondary amine

Fakhar, Imran; Hussien, Nasry Jassim; Sapari, Suhaila; Bloh, Anmar Hameed; Yusoff, Siti Fairus Mohd; Hasbullah, Siti Aishah; Yamin, Bohari M; Mutalib, Sahilah Abd.; Shihab, Mehdi Salih; Yousif, Emad

doi:10.1016/j.molstruc.2018.01.032

Cited by 8 publications

(1 citation statement)

References 29 publications

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“…Thiourea and its derivatives show a broad range of biological activities (Solmaz et al, 2018;Saeed et al, 2018;Pandey et al, 2019). The crystal structures of many thiourea derivatives and their metal complexes have been reported (Lai et al,2018;Contreras Aguilar et al, 2018;Fakhar et al, 2018;Mitoraj et al, 2018;Pervez et al, 2018;Hashim et al, 2017Ghazal et al, 2019Zhang et al, 2019). As part of our studies in this area, we now describe the syntheses, crystal structures and Hirshfeld surface analyses of the thiourea derivatives N-(2-chlorophenylcarbamothioyl)-4-fluorobenzamide (C 14 H 10 ClFN 2 OS, 1) and N-(4-bromophenylcarbamothioyl)-4-fluorobenzamide (C 14 H 10 BrFN 2 OS, 2).…”

Section: Chemical Contextmentioning

confidence: 99%

Crystal structure and Hirshfeld surface analysis of N-(2-chlorophenylcarbamothioyl)-4-fluorobenzamide and N-(4-bromophenylcarbamothioyl)-4-fluorobenzamide

et al. 2019

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The title compounds, C14H10ClFN2OS (1) and C14H10BrFN2OS (2), were synthesized by two-step reactions. The dihedral angles between the aromatic rings are 31.99 (3) and 9.17 (5)° for 1 and 2, respectively. Compound 1 features an intramolecular bifurcated N—H...(O,Cl) link due to the presence of the ortho-Cl atom on the benzene ring, whereas 2 features an intramolecular N—H...O hydrogen bond. In the crystal of 1, inversion dimers linked by pairs of N—H...S hydrogen bonds generate R 2 2(8) loops. The extended structure of 2 features the same motif but an additional weak C—H...S interaction links the inversion dimers into [100] double columns. Hirshfeld surface analyses indicate that the most important contributors towards the crystal packing are H...H (26.6%), S...H/H.·S (13.8%) and Cl...H/H...Cl (9.5%) contacts for 1 and H...H (19.7%), C...H/H...C (14.8%) and Br...H/H...Br (12.4%) contacts for 2.

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Section: Chemical Contextmentioning

confidence: 99%

Crystal structure and Hirshfeld surface analysis of N-(2-chlorophenylcarbamothioyl)-4-fluorobenzamide and N-(4-bromophenylcarbamothioyl)-4-fluorobenzamide

et al. 2019

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Facile synthesis of magnetic disinfectant immobilized with silver ions for water pathogenic microorganism’s deactivation

Elwakeel

El‐Liethy

Ahmed³

et al. 2018

Environ Sci Pollut Res

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One-pot synthesis of a new magnetic disinfectant was achieved through the polymerization of thiourea and formaldehyde in the presence of magnetite nanoparticles (MTUF). The obtained magnetic chelating resin was loaded with Ag(I) ions. This material was tested as a disinfectant for water pathogenic microorganism's deactivation. The toxicity of MTUF before and after Ag(I) loading was estimated. The antimicrobial activity tests of MTUF-Ag were carried out against Escherichia coli, Salmonella Typhimurium, and Pseudomonas aeruginosa as examples of Gram-negative bacteria; Listeria monocytogenes, Staphylococcus aureus, Enterococcus faecalis, and Bacillus subtilis as examples of Gram-positive bacteria; and Candida albicans as representative for fungi. The results showed that the minimum inhibitory dosage (MID) of MTF-Ag against Escherichia coli, Salmonella Typhimurium, Listeria monocytogenes, Staphylococcus aureus, and mixed culture were 1.5, 2.0, 1.0, 1.5, and 1.5 mg/mL, respectively, after 40 min of contact time. While C. albicans was more resistant to the magnetic disinfectant, only three log reductions were done at 2.5 mg/mL. The studied MTUF-Ag was successfully tested for water and wastewater pathogenic microorganism's deactivation. It can be concluded that MTUF-Ag could be a good candidate for water disinfection.

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Assessment on functionalized conjugated acetylide and its designated acetylide-imine moieties towards Acanthamoeba sp.: An in vitro bioindicator study

Manisekaran,

Khairul,

Foong

et al. 2024

Chemosphere

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Synthesis, X-Ray diffraction, theoretical and anti-bacterial studies of bis-thiourea secondary amine

Cited by 8 publications

References 29 publications

Crystal structure and Hirshfeld surface analysis of N-(2-chlorophenylcarbamothioyl)-4-fluorobenzamide and N-(4-bromophenylcarbamothioyl)-4-fluorobenzamide

Crystal structure and Hirshfeld surface analysis of N-(2-chlorophenylcarbamothioyl)-4-fluorobenzamide and N-(4-bromophenylcarbamothioyl)-4-fluorobenzamide

Facile synthesis of magnetic disinfectant immobilized with silver ions for water pathogenic microorganism’s deactivation

Assessment on functionalized conjugated acetylide and its designated acetylide-imine moieties towards Acanthamoeba sp.: An in vitro bioindicator study

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