Synthesis, X-ray structure and antimycobacterial activity of silver complexes with α-hydroxycarboxylic acids

Cuin, Alexandre; Massabni, Antônio Carlos; Leite, Clarice Q. F.; Sato, Daisy Nakamura; Neves, Ademir; Szpoganicz, Bruno; Silva, Marlon S.; Bortoluzzi, Adaı́lton J.

doi:10.1016/j.jinorgbio.2006.10.001

Cited by 53 publications

(34 citation statements)

References 25 publications

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“…Also the specific target enzyme can be mutated, so that the sensitivity for the antibiotic decreases. In the case of silver, some of the resistance genes that have been identified seem to be involved in pumping silver out of the cell [126]. Also the composition of the membrane can be changed so that silver affinity is lowered and antimicrobial activity is abolished.…”

Section: Mechanism Of Antibacterial Action Of Silvermentioning

confidence: 99%

New Strategies in the Development of Antimicrobial Coatings: The Example of Increasing Usage of Silver and Silver Nanoparticles

2011

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Bacterial infection from medical devices is a major problem and accounts for an increasing number of deaths as well as high medical costs. Many different strategies have been developed to decrease the incidence of medical device related infection. One way to prevent infection is by modifying the surface of the devices in such a way that no bacterial adhesion can occur. This requires modification of the complete surface with, mostly, hydrophilic polymeric surface coatings. These materials are designed to be non-fouling, meaning that protein adsorption and subsequent microbial adhesion are minimized. Incorporation of antimicrobial agents in the bulk material or as a surface coating has been considered a viable alternative for systemic application of antibiotics. However, the manifestation of more and more multi-drug resistant bacterial strains restrains the use of antibiotics in a preventive strategy. The application of silver nanoparticles on the surface of medical devices has been used to prevent bacterial adhesion and subsequent biofilm formation. The nanoparticles are either deposited directly on the device surface, or applied in a polymeric surface coating. The silver is slowly released from the surface, thereby killing the bacteria present near the surface. In the last decade there has been a surplus of studies applying the concept of silver nanoparticles as an antimicrobial agent on a range of different medical devices. The main problem however is that the exact antimicrobial mechanism of silver remains unclear. Additionally, the antimicrobial efficacy of silver on OPEN ACCESSPolymers 2011, 3 341 medical devices varies to a great extent. Here we will review existing antimicrobial coating strategies and discuss the use of silver or silver nanoparticles on surfaces that are designed to prevent medical device related infections.

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Section: Mechanism Of Antibacterial Action Of Silvermentioning

confidence: 99%

New Strategies in the Development of Antimicrobial Coatings: The Example of Increasing Usage of Silver and Silver Nanoparticles

2011

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“…There is much evidence that metal complexes, such as silver, copper and iron, are effective anticancer agents [1,2]. The success of cisplatin as an anticancer agent has stimulated the search for cytotoxic compounds with a more acceptable toxicity profile and enhanced activity [3].…”

Section: Introductionmentioning

confidence: 99%

Mutagenic and Genotoxic Effects of cis-(Dichloro)tetraammineruthenium(III) Chloride on Human Peripheral Blood Lymphocytes

Ribeiro

Silva

Pereira

et al. 2009

Biol Trace Elem Res

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Chemotherapeutic agents play an important role in cancer treatment mostly due their systemic action on human organism allowing access to liquid tumors and even metastases. Among these drugs, ruthenium compounds have been showing promising results to treat tumors and represent an important development of new antitumor therapy. This study presents the evaluation of cis-(dichloro)tetraammineruthenium(III) chloride, cis-[RuCl(2)(NH(3))(4)]Cl, genotoxic effects using human peripheral blood lymphocytes cultured in vitro. Mitotic index (MI), chromosome aberrations (CA), and DNA damage using the comet assay were analyzed. MI in human peripheral blood lymphocyte cultures treated with 1, 10, 100, and 1,000 microg mL(-1) cis-[RuCl(2)(NH(3))(4)]Cl were 5.9%, 4.6%, 3.9%, and 0%, respectively. Doxorubicin chloridate was used as the positive control. CA derived from 1, 10, and 100 microg mL(-1) concentrations were defined as spontaneous when compared with the negative control, and at the concentration of 1,000 microg mL(-1), the cell cycle was inhibited (IM = 0%). Results obtained for the comet assay using cis-[RuCl(2)(NH(3))(4)]Cl suggest that this compound has no genotoxic activity against cultured human peripheral blood lymphocytes.

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“…13 Some of this resistance appears to be related to genes that control the pumping of silver out of the cell. 14 Taglietti et al 15 showed that a self-assembled monolayer of silver nanoparticles on glass was obtained via amino-silanisation of the glass surface. They found that there was prolonged release of silver ions, whereas the silver nanoparticles remained attached to the underlying substrate, and strong antibiofilm activity against the biofilm-producer Staphylococcus epidermidis was detected.…”

Section: Mechanism Of Actionmentioning

confidence: 99%

Silver nanoparticles and their orthopaedic applications

Brennan

Fhoghlu

Devitt

et al. 2015

The Bone & Joint Journal

155

114

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Implant-associated infection is a major source of morbidity in orthopaedic surgery. There has been extensive research into the development of materials that prevent biofilm formation, and hence, reduce the risk of infection. Silver nanoparticle technology is receiving much interest in the field of orthopaedics for its antimicrobial properties, and the results of studies to date are encouraging. Antimicrobial effects have been seen when silver nanoparticles are used in trauma implants, tumour prostheses, bone cement, and also when combined with hydroxyapatite coatings. Although there are promising results with in vitro and in vivo studies, the number of clinical studies remains small. Future studies will be required to explore further the possible side effects associated with silver nanoparticles, to ensure their use in an effective and biocompatible manner. Here we present a review of the current literature relating to the production of nanosilver for medical use, and its orthopaedic applications. Silver is a soft, white, lustrous transition metal which is recognised to have antimicrobial properties and has assumed an important role in the treatment of infections.1-3 As a non-specific biocidal agent, in suitable doses silver is not toxic to mammalian cells and disinfects a broad spectrum of bacterial and fungal species, including antibiotic-resistant strains.1-3 Silver and silver nanoparticles are used as antimicrobials in a variety of industrial, healthcare and domestic applications. 4,5 Silver has been incorporated into wound dressings, and as an antimicrobial coating on medical devices in order to prevent biofilm formation.6 The clinical potential of silver nanotechnology is of particular interest to the field of orthopaedics, where infection of implanted devices represents a persistent threat. In this paper we provide a review of the literature on the use of silver nanoparticles and their application in the field of orthopaedics. In addition, we review the potential for toxicity if silver is not used with caution.

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Synthesis, X-ray structure and antimycobacterial activity of silver complexes with α-hydroxycarboxylic acids

Cited by 53 publications

References 25 publications

New Strategies in the Development of Antimicrobial Coatings: The Example of Increasing Usage of Silver and Silver Nanoparticles

New Strategies in the Development of Antimicrobial Coatings: The Example of Increasing Usage of Silver and Silver Nanoparticles

Mutagenic and Genotoxic Effects of cis-(Dichloro)tetraammineruthenium(III) Chloride on Human Peripheral Blood Lymphocytes

Silver nanoparticles and their orthopaedic applications

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