Synthesis, X-ray structures, spectroscopic analysis and anticancer activity of novel gold(I) carbene complexes

Altaf, Muhammad; Monim-ul-Mehboob, Muhammad; Seliman, Adam A.A.; Isab, Anvarhusein A.; Dhuna, Vikram; Bhatia, Gaurav; Dhuna, Kshitija

doi:10.1016/j.jorganchem.2014.04.029

Cited by 36 publications

(20 citation statements)

References 33 publications

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“…The success of platinum compounds against different types of cancers triggered a great deal of interest in the field of anti‐tumor metallodrugs . In this regard, gold(I) and gold(III) complexes have attracted special attention because some gold(I) complexes have already been used over many years for the treatment of rheumatoid arthritis , . The antirheumatic gold(I)‐phosphine drug, auranofin emerged as the lead compound for the antiproliferatively active gold species .…”

Section: Introductionmentioning

confidence: 99%

“…Motivated by the promising results of our recent studies on the antitumor properties of gold(I) complexes containing phosphine and dithiocarbamate ligands,, , we prepared in the current study, two new gold(I) complexes of 2‐(diphenylphosphanyl)ethylamine or (2‐aminoethyl)diphenylphosphine ( 1 , 2 ) and three gold(I)‐dithiocarbamates ( 3 – 5 ). The complexes were characterized by elemental analysis, IR, 1 H, 13 C, and 31 P NMR spectroscopy and their antitumor activity was examined against A549 (human lung carcinoma), HCT15 (human colon cancer), and MCF7 (human breast cancer) cell lines by MTT assay.…”

Section: Introductionmentioning

confidence: 99%

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Synthesis, Characterization, andin vitroCytotoxicity of Gold(I) Complexes of 2-(Diphenylphosphanyl)ethylamine and Dithiocarbamates

Sulaiman

Altaf

Isab

et al. 2016

Z. Anorg. Allg. Chem.

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Gold(I) complexes of 2-(diphenylphosphanyl)ethylamine or (2-aminoethyl)diphenylphosphine (AEP), and dithiocaarbamates (R 2 NCS 2 ) were prepared by the reaction of these ligands with (CH 3 ) 2 S-AuCl in dichloromethane. The synthesized complexes [Au(AEP)Cl] (1), [Au(AEP) 2 ]Cl (2), and [Au 2 (R 2 NCS 2 ) 2 ] n (R 2 = dimethyl (3), diethyl (4), and dibenzyl (5)) were characterized by ele-* Dr. A. A. Isab

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Synthesis, Characterization, andin vitroCytotoxicity of Gold(I) Complexes of 2-(Diphenylphosphanyl)ethylamine and Dithiocarbamates

Sulaiman

Altaf

Isab

et al. 2016

Z. Anorg. Allg. Chem.

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“…Similar to 1, the Au-P bond distance is 2.2581(2) Å and the Au-S bond distance of 2.3247(2) Å is typical for Au(I) dithiocarbamates. For reference, the Au-S bond distances in (IPr)Au(S2CNEt2) and (IPr)Au[S2CN(CH2Ph)2], IPr = 1,3-bis(2,6-diisopropylphenyl)imidazole-2-ylidene, are 2.314(5) and 2.2999(12) Å, respectively [27], and 2.312(3) Å in Ph3PAu(indazol-1-yldithiocarbamate) [28]. With the recent use of CsBr3 to oxidize Au(I) to Au(III), we attempted a similar reaction with 1 [29].…”

Section: Resultsmentioning

confidence: 99%

Reactivity of Mononuclear and Dinuclear Gold(I) Amidinate Complexes with CS2 and CsBr3

et al. 2014

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“…Recently, the broad applications of NHC‐based (NHC=N‐heterocyclic carbene) gold(I) and (III) complexes in catalysis and their biological activities have also attracted much interest from researchers and the pharmaceutical sector . Benzimidazole‐ and imidazole‐containing drugs are currently in use as antiviral, antifungal, antihelmentic and diuretic .…”

Section: Figurementioning

confidence: 99%

In vitro Biological Activities of Gold(I) and Gold(III) Bis(N-Heterocyclic Carbene) Complexes

et al. 2017

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The aim of this research is to evaluate for the first time the in vitro leishmanicidal activity and inhibition of a-glucosidase and b-glucuronidase of new gold(I) and gold(III) complexes involving N-heterocyclic carbene (NHC) ligands, with the general formula [Au(X) n (NHC)R 2 ][BF 4 ] (X=Cl, OAc, R = various aromatic and aliphatic substituents). The Au(III) complexes were shown to have a significant antileishmanial activity, and were also found to be more potent inhibitors of a-glucosidase and b-glucuronidase enzymes than the standard drugs. Some complexes were also identified as potent anti-inflammatory agents with activity comparable to that of tested standard drugs, allopurinol and ibuprofen. These gold complexes were also evaluated for their in vitro cytotoxic activity against HeLa (cervical cancer), MCF-3 (breast cancer), and 3T3 (mouse fibroblast) cell lines.Recent advancements in transition-metal-based compounds have found wide medical applications. The use of cisplatin to treat ovarian cancer and the discovery of the gold-based drug auranofin to treat rheumatoid arthritis are among the numerous examples that have seen transition metal complexes combat human ailments. Nowadays, large libraries of platinum-, palladium-, ruthenium-and gold-containing molecules are being synthesized for therapeutic purposes. [1][2][3]

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Synthesis, X-ray structures, spectroscopic analysis and anticancer activity of novel gold(I) carbene complexes

Cited by 36 publications

References 33 publications

Synthesis, Characterization, andin vitroCytotoxicity of Gold(I) Complexes of 2-(Diphenylphosphanyl)ethylamine and Dithiocarbamates

Synthesis, Characterization, andin vitroCytotoxicity of Gold(I) Complexes of 2-(Diphenylphosphanyl)ethylamine and Dithiocarbamates

Reactivity of Mononuclear and Dinuclear Gold(I) Amidinate Complexes with CS2 and CsBr3

In vitro Biological Activities of Gold(I) and Gold(III) Bis(N-Heterocyclic Carbene) Complexes

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