Synthesis, XRD, thermal, spectroscopic studies and biological evaluation of Co(II), Ni(II) Cu(II) metal complexes derived from 2-benzimidazole

Manjuraj, T.; Krishnamurthy, G.; Bodke, Yadav D.; Naik, H.S. Bhojya; Kumar, Harikesh

doi:10.1016/j.molstruc.2018.06.055

Cited by 29 publications

(7 citation statements)

References 22 publications

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“…The average crystalline sizes ( d XRD ) of meloxicam complexes were calculated by

Debye Scherrer equation (D) = \frac{italicKλ}{β \cos θ}

where θ = diffraction angle, β = full width at half maximum (FWHM), λ = X‐ray wavelength (0.15406 Å), K = dimensionless shape factor, and D = particle size of the crystallite (Table S2). [ 60 ] The d XRD for Mg(II) complex was 25.52 nm and for Sr(II) complex was 29.04 nm, which showed nanocrystalline phase of both complexes.…”

Section: Resultsmentioning

confidence: 99%

Synthesis, spectroscopic, in vitro, in vivo biological evaluation, and in silico docking analysis of new meloxicam metal complexes

Samra

Basra

2023

Applied Organom Chemis

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In the present study, two new meloxicam complexes with Mg(II) and Sr(II) were synthesized and characterized by spectroscopic and analytical methods, that is, UV–vis, IR, 1H NMR, 13C NMR, powder XRD, SEM–EDX, and TG analysis. The biological evaluation was done by in vitro antioxidant, BSA‐binding, DNA cleavage activities, and in vivo anti‐inflammatory, analgesic, and anxiolytic methods. Furthermore, in silico docking was done with Keap1 receptor to visualize the anti‐inflammatory effect of complexes. The spectral characterization suggested that meloxicam coordinated with the metal ions by oxygen and nitrogen of amide group and thiazolyl ring (Oamide and Nthiazolyl), respectively. The SEM pictures depicted dissimilar morphologies, and the powder XRD patterns showed different crystallinities of complexes than meloxicam. TG analysis exhibited high thermal stabilities of complexes and Coats–Redfern method was employed to calculate the important thermodynamic parameters. The complexes showed effective biological activities and enhanced safety index (LD50 = 1000 mg kg−1). The Mg(II) complex revealed greatest inhibitory effects in carrageenan‐induced paw inflammation (92.85%) and in acetic acid‐induced writhing (71.05%). Furthermore, the complexes showed higher potential to bind with BSA and cleave the DNA as compared with the meloxicam. Moreover, molecular docking against Keap1 showed that Mg(II) complex inhibited Keap1 with highest docking score (6166 kcal mol−1), docking area (804.40) and ACE (−417.49 kJ mol−1) which explained its higher anti‐inflammatory effect. Mg(II) complex of meloxicam might be considered as a candidate anti‐inflammatory drug; however, more research is required to investigate their other biological potential.

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“…The average crystalline sizes ( d XRD ) of meloxicam complexes were calculated by

Debye Scherrer equation (D) = \frac{italicKλ}{β \cos θ}

Section: Resultsmentioning

confidence: 99%

Synthesis, spectroscopic, in vitro, in vivo biological evaluation, and in silico docking analysis of new meloxicam metal complexes

Samra

Basra

2023

Applied Organom Chemis

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“…It is observed from X-ray diffractogram that complexation of meloxicam with calcium metal enhanced its crystallinity. The average crystalline sizes of the Ca(II) complex ( d XRD ) were calculated using Debye–Scherrer equation ( D = Kλ / β Cos θ ), where D = particle size, K = dimensionless shape factor, λ = X-ray wavelength (0.15406 Å), β = full width at half maximum (FWHM) of the diffraction peak, and θ = diffraction angle [ 45 ]. The synthesized Ca(II) complex has a crystalline size of 32.86 nm suggesting that the complex is in a nanocrystalline phase.…”

Section: Resultsmentioning

confidence: 99%

Synthesis, Spectroscopic and Biological Investigation of a New Ca(II) Complex of Meloxicam as Potential COX-2 Inhibitor

et al. 2022

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Drug development on basis of coordination compounds provides versatile structural and functional properties as compared to other organic compounds. In the present study, a new Ca(II) complex of meloxicam was synthesized and characterized by elemental analysis, FT-IR, UV–Vis, 13 C NMR, SEM–EDX, powder XRD and thermal analysis (TGA). The Ca(II) complex was investigated for its in vitro, in vivo biological activities and in silico docking analysis against COX-1 and COX-2. The spectral analysis indicates that the meloxicam acts as a deprotonated bidentate ligand (coordinated to the metal atom through the amide oxygen and the nitrogen atom of the thiazolyl ring) in the complex. SEM–EDX and powder XRD analysis depicted crystalline morphology of Ca(II) complex with a crystalline size of 32.86 nm. The in vitro biological activities were evaluated by five different antioxidant methods and COX inhibition assay, while in vivo activities were evaluated by carrageenan-, histamine- and PGE 2 -induced paw edema methods and acetic acid-induced writhing test. The Ca(II) complex showed prominent antioxidant activities and was found to be more selective toward COX-2 (43.77) than COX-1 as compared to meloxicam. It exhibited lower toxicity (LD 50 1000 mg/Kg) and significantly inhibited carrageenan- and PGE 2 -induced inflammation at 10 mg/Kg ( P < 0.05), but no significant effect was observed on histamine-induced inflammation. Moreover, Ca(II) complex significantly reduced the number of writhes induced by acetic acid ( P < 0.05). The in silico molecular docking data revealed that Ca(II) complex obstructed COX-2 (dock score 6438) more effectively than COX-1 (dock score 5732) as compared to meloxicam alone.

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“…The average crystalline sizes of the complexes calculated using Debye Scherrer equation of [Ni(ace) 2 (PPh 3 ) 2 ](4), [Cu(ace) 2 (H 2 O) 2 ](5) and [Cu(ace) 2 (PPh 3 ) 2 ](6) are 34.02, 31.50 and 23.86 nm, respectively suggesting the nanocrystalline phase of all the complexes. (Manjuraj, 2018) The biological studies display the effect of mixed ligands towards the inhibition of A549 lung cancer cells growing. Starting materials provide high IC 50 values which indicate unsatisfactory ability in the interaction with biological substrates and some cannot be even evaluated the IC 50 values.…”

Section: Discussionmentioning

confidence: 99%

“…The X-ray diffraction pattern of the complexes representing in Figure 8, 9 and 10, respectively and d-spacing corelated to θ are given in Table 3. The average crystalline sizes of the complexes were calculated using Debye Scherrer equation (D = Kƛ/βcos θ) (D = Particle size, K = Dimensionless shape factor, ƛ = X-ray wavelength (0.154 Å) β = full width at half maximum of the diffraction peak, θ = Diffraction angle) (Manjuraj, 2018).…”

Section: X-ray Powder Diffraction Studiesmentioning

confidence: 99%

Anticancer Activity of Metal Complexes with Acesulfame Mixed with Triphenylphosphine Ligands

Boonseng¹,

Khudkham²,

Wongsuwan³

et al. 2019

CMUJNS

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Metal complexes of silver(I), nickel(II) and copper(II) with the mixed ligands of acesulfame (ace) and triphenylphosphine (PPh 3) were prepared in this work. The complexes of [Ag(ace)] n (1), [Ag(ace)(PPh 3)] (2), [Ni(ace) 2 (H 2 O) 4 ] (3),[Ni(ace) 2 (PPh 3) 2 ] (4), [Cu(ace) 2 (H 2 O) 2 ] (5) and [Cu(ace) 2 (PPh 3) 2 ] (6) were characterised by FT-IR and NMR spectroscopy, Mass spectrometry including X-Ray powder diffraction. The synthesised complexes were examined in their anticancer activity against A549 lung cancer cells which were further evaluated their efficiency by IC 50 method. [Ag(ace)] n (1), [Ni(ace) 2 (H 2 O) 4 ] (3) and [Cu(ace) 2 (H 2 O) 2 ] (5) which contain only acesulfame ligand exhibited higher IC 50 values in comparison to the mixed ligands of ace and PPh 3. [Ag(ace)(PPh 3)] (2), [Ni(ace) 2 (PPh 3) 2 ] (4) and [Cu(ace) 2 (PPh 3) 2 ] (6) displayed the inhibition in the growth of cancer cells with IC 50 values of 1.65, 13.45 and 1.06 µM, respectively. Additionally, silver(I) and copper(II) complexes also presented better activity than the standard Etoposide (IC 50 5.623 µM). The results indicated that the mixed ligands could perform more excellent inhibition of cancer cells growing in comparison to the using of only acesulfame or triphenylphosphine ligand.

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Synthesis, XRD, thermal, spectroscopic studies and biological evaluation of Co(II), Ni(II) Cu(II) metal complexes derived from 2-benzimidazole

Cited by 29 publications

References 22 publications

Synthesis, spectroscopic, in vitro, in vivo biological evaluation, and in silico docking analysis of new meloxicam metal complexes

Synthesis, spectroscopic, in vitro, in vivo biological evaluation, and in silico docking analysis of new meloxicam metal complexes

Synthesis, Spectroscopic and Biological Investigation of a New Ca(II) Complex of Meloxicam as Potential COX-2 Inhibitor

Anticancer Activity of Metal Complexes with Acesulfame Mixed with Triphenylphosphine Ligands

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