Synthetic and Biophysical Studies on the Tridachiahydropyrone Family of Natural Products

Powell, Kimberley Jade

doi:10.1007/978-3-319-22069-7

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“…[ 2,81 ] Di‐ or tri‐substituted vinyl halides can be transformed into acrylonitriles with a cyanide source in the presence of an appropriate metal‐based catalyst. KCN, [ 82–84 ] Zn(CN) 2 , [ 85,86 ] acetone cyanohydrin, [ 9 ] and potassium hexacyanoferrate (K 4 [Fe(CN) 6 ]) [ 87,88 ] have been used as cyanide sources.…”

Section: Synthetic Strategies Of Acrylonitrilesmentioning

confidence: 99%

“…As a pharmacophore, acrylonitrile is found in the structure of many naturally occurring compounds. Calyculins (known to be protein phosphatase inhibitors), [ 5,9 ] borrelidin (known to be an antibiotic, antimalarial, and antifungal agent), [ 10–13 ] and some cyanoglycosides [ 4,14–16 ] such as simmondsin (known to be a food intake inhibitor), bauhinin (known to be a piscicidal), and menisdaurin are some examples (Figure 2).…”

Section: Introductionmentioning

confidence: 99%

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Insights into the chemistry and therapeutic potential of acrylonitrile derivatives

Tan

Zengin

2021

Archiv der Pharmazie

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Acrylonitrile is a fascinating scaffold widely found in many natural products, drugs, and drug candidates with various biological activities. Several drug molecules such as entacapone, rilpivirine, teriflunomide, and so forth, bearing an acrylonitrile moiety have been marketed. In this review, diverse synthetic strategies for constructing desired acrylonitriles are discussed, and the different biological activities and medicinal significance of various acrylonitrile derivatives are critically evaluated. The information gathered is expected to provide rational guidance for the development of clinically useful agents from acrylonitriles.

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