Synthetic enamine naphthoquinone derived from lawsone as cytotoxic agents assessed by in vitro and in silico evaluations

Synthetic Naphthoquinone Derivatives as Anticancer Agents in Ovarian Cancer: Cytotoxicity Assay and Investigation of Possible Biological Mechanisms Action

“…The synthesis and evaluation of the biological activity of new naphthoquinone derivatives has been the object of studies by our research group over the last decade and some recently developed compounds are presented in Figure 1 [16–21] …”

“…[14,15] The synthesis and evaluation of the biological activity of new naphthoquinone derivatives has been the object of studies by our research group over the last decade and some recently developed compounds are presented in Figure 1. [16][17][18][19][20][21] In this work, we report anticancer activity of sulfurcontaining naphthoquinone derivatives 1 -4 and naphthoquinone-polyphenols 5-8 (Figure 2) in A2780 epithelial OVCA cell lines and its probable mechanisms of biological action. We assessed the anticancer activity of these compounds by MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) based assay.…”