Synthetic Lipid Nanoparticles Targeting Steroid Organs

Mérian, Juliette; Boisgard, Raphaël; Declèves, Xavier; Thézé, Benoît; Texier, Isabelle; Tavitian, Bertrand

doi:10.2967/jnumed.113.121657

Cited by 24 publications

(22 citation statements)

References 40 publications

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“…LNEs are 50-nm DiD-loaded lipidic nanoparticles, with chemical properties close to those of LNCs, although their elasticity and surface coating are different. After intravenous injection, LNEs were distributed in the body with a hepatic elimination and a mean residence time of 8 hours in the blood 20 ( Supp. Fig.…”

Section: Resultsmentioning

confidence: 99%

An MRI-based classification scheme to predict passive access of 5 to 50-nm large nanoparticles to tumors

Karageorgis

Dufort

Sancey

et al. 2016

Sci Rep

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Nanoparticles are useful tools in oncology because of their capacity to passively accumulate in tumors in particular via the enhanced permeability and retention (EPR) effect. However, the importance and reliability of this effect remains controversial and quite often unpredictable. In this preclinical study, we used optical imaging to detect the accumulation of three types of fluorescent nanoparticles in eight different subcutaneous and orthotopic tumor models, and dynamic contrast-enhanced and vessel size index Magnetic Resonance Imaging (MRI) to measure the functional parameters of these tumors. The results demonstrate that the permeability and blood volume fraction determined by MRI are useful parameters for predicting the capacity of a tumor to accumulate nanoparticles. Translated to a clinical situation, this strategy could help anticipate the EPR effect of a particular tumor and thus its accessibility to nanomedicines.

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Section: Resultsmentioning

confidence: 99%

An MRI-based classification scheme to predict passive access of 5 to 50-nm large nanoparticles to tumors

Karageorgis

Dufort

Sancey

et al. 2016

Sci Rep

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“…18 The oil-in-water (O/W) nanoemulsion of PSO denominated as Nano-PSO 19 may increase the bioability and activity of PSO. This approach, as is the case for delivery systems, such as phospholipid micelles or nanodroplets, [20][21][22] may allow the distribution of the oil components to organs other than the liver, thereby enabling a longer circulation that may increase the levels of PA available to pass the blood-brain barrier (BBB). Indeed, similar unsaturated fatty acids, such as linoleic acid, were shown to readily cross the BBB.…”

Section: Introductionmentioning

confidence: 99%

Treatment of a multiple sclerosis animal model by a novel nanodrop formulation of a natural antioxidant

Binyamin¹,

Larush²,

Frid³

et al. 2015

IJN

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Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system and is associated with demyelination, neurodegeneration, and sensitivity to oxidative stress. In this work, we administered a nanodroplet formulation of pomegranate seed oil (PSO), denominated Nano-PSO, to mice induced for experimental autoimmune encephalomyelitis (EAE), an established model of MS. PSO comprises high levels of punicic acid, a unique polyunsaturated fatty acid considered as one of the strongest natural antioxidants. We show here that while EAE-induced mice treated with natural PSO presented some reduction in disease burden, this beneficial effect increased significantly when EAE mice were treated with Nano-PSO of specific size nanodroplets at much lower concentrations of the oil. Pathological examinations revealed that Nano-PSO administration dramatically reduced demyelination and oxidation of lipids in the brains of the affected animals, which are hallmarks of this severe neurological disease. We propose that novel formulations of natural antioxidants such as Nano-PSO may be considered for the treatment of patients suffering from demyelinating diseases. On the mechanistic side, our results demonstrate that lipid oxidation may be a seminal feature in both demyelination and neurodegeneration.

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“…Lipid nanoparticles used in this study (Lipidots™) display increased affinity for myeloid cells such as macrophages, or denditric cells (Courant, et al, 2017), and a biodistribution pattern with high uptake in lipid-rich areas, such as adrenals, ovaries and testis, and liver, where they are metabolized (Merian, et al, 2013). Their size is easily adjustable and lipid composition is similar to those of low density lipoproteins.…”

Section: Lipid-based Nanoparticlesmentioning

confidence: 99%

Comparative analysis of nanosystems’ effects on human endothelial and monocytic cell functions

et al. 2018

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The objective of our work was to investigate the effects of different types of nanoparticles on endothelial (HUVEC) and monocytic cell functions. We prepared and tested 14 different nanosystems comprising liposomes, lipid nanoparticles, polymer and iron oxide nanoparticles. Some of the tested nanosystems contained targeting, therapeutic, or contrast agent(s). The effect of particles (0-400 µg/mL) on endothelial-monocytic cell interactions in response to TNF-α was investigated using an arterial bifurcation model and dynamic monocyte adhesion assay. Spontaneous HUVEC migration (0-100 µg/mL nanoparticles) and chemotaxis of monocytic cells towards MCP-1 in presence of particles (0-400 µg/mL) were determined using a barrier assay and a modified Boyden chamber assay, respectively. Lipid nanoparticles dose-dependently reduced monocytic cell chemotaxis and adhesion to activated HUVECs. Liposomal nanoparticles had little effect on cell migration, but one formulation induced monocytic cell recruitment by HUVECs under non-uniform shear stress by about 50%. Fucoidan-coated polymer nanoparticles (25-50 µg/mL) inhibited HUVEC migration and monocytic cell chemotaxis, and had a suppressive effect on monocytic cell recruitment under non-uniform shear stress. No significant effects of iron oxide nanoparticles on monocytic cell recruitment were observed except lauric acid and human albumin-coated particles which increased endothelial-monocytic interactions by 60-70%. Some of the iron oxide nanoparticles inhibited HUVEC migration and monocytic cell chemotaxis. These nanoparticle-induced effects are of importance for vascular cell biology and function and must be considered before the potential clinical use of some of the analyzed nanosystems in cardiovascular applications.

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Synthetic Lipid Nanoparticles Targeting Steroid Organs

Cited by 24 publications

References 40 publications

An MRI-based classification scheme to predict passive access of 5 to 50-nm large nanoparticles to tumors

An MRI-based classification scheme to predict passive access of 5 to 50-nm large nanoparticles to tumors

Treatment of a multiple sclerosis animal model by a novel nanodrop formulation of a natural antioxidant

Comparative analysis of nanosystems’ effects on human endothelial and monocytic cell functions

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