Synthetic Nerve Guide Implants in Humans: A Comprehensive Survey

Schlosshauer, Bürkhard; Dreesmann, Lars; Schaller, Hans-Eberhard; Sinis, Nektarios

doi:10.1227/01.neu.0000235197.36789.42

Cited by 233 publications

(157 citation statements)

References 40 publications

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“…PGA is degraded into lactic acid in 6-12 months [73,90]. Therefore, critics claim that PGA may degrade faster than the regeneration process and resulting lactic acid may a have toxic effects [84,[141][142][143]. Dellon and Mackinnon [144] were the first to report the use of PGA conduits as secondary reconstitution of digital nerve defects 3 cm or smaller in 15 clinical cases in monkeys.…”

Section: Polyglycolic Acidmentioning

confidence: 99%

Scaffolds for Peripheral Nerve Regeneration, the Importance of In Vitro and In Vivo Studies for the Development of Cell-Based Therapies and Biomaterials: State of the Art

Pedrosa¹,

Caseiro²,

Santos³

et al. 2017

Scaffolds in Tissue Engineering - Materials, Technologies and Clinical Applications

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Human adult peripheral nerve injuries are a high incidence clinical problem that greatly affects patients' quality of life. Although peripheral nervous system has intrinsic regenerative capacity, this occurs in an incomplete or poorly functional manner. When a nerve fiber loses its continuity with consequent damage of the basal lamina tubes, axon spontaneous regeneration is disorganized and mismatched. These phenomena translate in an inadequate nerve functional recovery and consequent musculoskeletal incapacity. Nerve grafts still remain the gold standard in peripheral injuries treatment. However, this approach contains its disadvantages such as the necessity of primary surgery to harvest the autografts, loss of a functional nerve, donor site morbidity and longer surgery procedures. Therefore, biomaterials and tissue engineering can provide efficient resources and alternatives to nerve injury repair not only by the development of biocompatible structures but also, introducing neurotrophic factors and cellular systems to stimulate optimum clinical outcome. In this chapter, a comprehensive state-of-the art picture of tissue-engineered nerve grafts scaffolds, their application in nerve regeneration along with latest advances in peripheral nerve repair and future perspectives will be discussed, including our own large experience in this field of knowledge.

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Section: Polyglycolic Acidmentioning

confidence: 99%

Scaffolds for Peripheral Nerve Regeneration, the Importance of In Vitro and In Vivo Studies for the Development of Cell-Based Therapies and Biomaterials: State of the Art

Pedrosa¹,

Caseiro²,

Santos³

et al. 2017

Scaffolds in Tissue Engineering - Materials, Technologies and Clinical Applications

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show abstract

“…Though an autologous nerve graft is the gold standard of nerve graft repair, it has several disadvantages, including the need for an extra incision, loss of donor nerve function, mismatch in size between the donor nerve and the injured nerve, and a limited availability of donor nerve. A diverse array of synthetic and natural materials has been studied in peripheral nerve repair, but these studies have shown limited success [1][2][3][4][5][6][7][8][9][10][11][12].…”

Section: Introductionmentioning

confidence: 99%

Controlling dispersion of axonal regeneration using a multichannel collagen nerve conduit

et al. 2010

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Single channel conduits are used clinically in nerve repair as an alternative to the autologous nerve graft.Axons regenerating across single channel tubes, however, may disperse resulting in inappropriate target reinnervation. This dispersion may be limited by multichannel nerve conduits as they resemble the structure of nerve multiple basal lamina tubes. In this study, we investigated the influence of channel number on the axonal regeneration using a series of 1-, 2-, 4-, and 7-channel collagen conduits and commercial (NeuraGen ® ) single channel conduits. Nerve conduits were implanted in rats with a 1cm gap of sciatic nerve.After four months, quantitative results of regeneration were evaluated with nerve morphometry and the accuracy of regeneration was assessed using retrograde tracing: two tracers being applied simultaneously to tibial and peroneal nerves to determine the percentage of motor neurons with double projections. Recovery of function was investigated with compound muscle action potential recordings and ankle motion analysis. We showed that the fabricated 1-channel and 4-channel conduits are superior to other types of conduits in axonal regeneration. Simultaneous tracing showed a significantly lower percentage of motor neurons with double projections after 2-and 4-channel compared with 1-channel conduit repair. This study shows the potential influence of multichannel guidance on limiting dispersion without decreasing quantitative results of regeneration.

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“…30 mm nin altındaki kısa periferal sinir defektlerinde endike olduğu bildirilmiştir. 34 Otojen kaynaklı entübülasyon gereçleri; ven, kollajen, kas ve fasyalardır. Alloplastik kaynaklı entübülasyon gereçle-rinden popüler olanları ise; politetrafloroetilen (goretex), silikon ve polyglikolik asit (neurotube) sayılabilir.…”

Section: Entübülasyonunclassified

Di̇ş Heki̇mli̇ği̇nde Peri̇feri̇k Si̇ni̇r Yaralanmalari Ve Tedavi̇si̇

Er¹,

Duygu²,

Çanakçi³

et al. 2015

Atatürk Üniversitesi Diş Hekimliği Fakültesi Dergisi

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ÖZDiş hekimliğinde periferik sinir yaralanmaları, rutin işlemler sırasında, cerrahi uygulamalarda veya travma sonucunda sıklıkla karşılaşılan olgulardır. Sinirin yapısı ve sinir hasarı mekanizmaları konusunda bilgi sahibi olmak, doğru teşhis ve tedavi için oldukça önemlidir. Sinir yaralanmalarının tedavisi, temel olarak medikal tedavi ve cerrahi tedavi olarak ikiye ayrılır. Medikal tedavinin sonuç vermediği hastalarda, muhtemel cerrahi tedavi için seçenek ve sonuçlarını bilmek, bu kritik komplikasyonda, doğru zamanlama ve uygulama açısından büyük önem arz etmektedir. Bu derlemenin amacı; diş hekimliği klinik uygulamalarında karşılaşıla-bilecek periferik sinir yaralanmaları sebeplerini hatırlamak ve mevcut kitap bilgileri ile güncel literatür bilgilerini harmanlayarak bu önemli komplikasyon hakkında bilgi sahibi olmaktır. Anahtar kelimeler: diş hekimliği; medikal tedavi; periferik sinir yaralanması; sinir cerrahisi GĠRĠġSinir sistemi iç ve dış ortamda oluşan değişik-liklere ani yanıtın oluşturulduğu sistemdir. İç ortamda oluşan değişiklikleri düz kas, kalp kası ve salgı bezlerine gönderdiği emirlerle düzenleyip kontrol ederken; dış ortamda oluşan değişikliklere iskelet kaslarına emir göndererek yanıt verir. 1 İnsan vücudunda, sinir sistemi; merkezi sinir sistemi (MSS) ve periferik (çevresel) sinir sistemi (PSS) olarak iki kısımda incelenir.PSS'yi oluşturan sinirler horizontal kesitte içten dışa doğru incelendiğinde en dışta arter, ven ve lenfa- ABSTRACTPeripheral nerve injuries are frequently seen during routine procedures, surgical operations or after traumas in dentistry. Knowledge about the structure of the nerve tissue and nerve damage mechanisms is important for accurate diagnosis and treatment. Management of nerve injury is basically divided in two as medical and surgical treatment. It has a great importance to be aware of surgical treatment options and their possible results for correct timing and treatment in patients who do not respond to medical therapy. The purpose of this review is to to have information about peripheral nerve injuries and recent treatment approaches in clinical dental practice combining the book information and current literature. Key words: dentistry; peripheral nerve injury; medical treatment; surgical treatment tiklerin bulunduğu gevşek yapısı ile siniri dış etkenlere karşı koruyan epinöriyum tabakası görülür. Hemen altındaki perinöriyum, fasikül adı verilen akson demetlerini saran kuvvetli bir bağ dokusu olup, travma ve iskemiye karşı çok dayanıklıdır ve bu bariyerin bozulması halinde sinir iletimi önemli ölçüde etkilenir. Endonöriyum ise sinir liflerini çevreleyen gevşek bağ dokusu olup, içerisinde aksonlar, Schwann hücreleri, kollajen lifler, fibroblastlar, kapiller damarlar ve az sayıda mast hücresi ile makrofajlar vardır. Fasikül ise periferik sinirin en küçük anatomik birimi olup, cerrahi olarak diseke edilebilir ve görülebilir. 2

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Synthetic Nerve Guide Implants in Humans: A Comprehensive Survey

Abstract: To treat longer defects, further implant development is needed, a goal that could be achieved, for example, by more closely imitating the intact nerve architecture and regulatory cell-cell interactions.

Cited by 233 publications

References 40 publications

Scaffolds for Peripheral Nerve Regeneration, the Importance of In Vitro and In Vivo Studies for the Development of Cell-Based Therapies and Biomaterials: State of the Art

Scaffolds for Peripheral Nerve Regeneration, the Importance of In Vitro and In Vivo Studies for the Development of Cell-Based Therapies and Biomaterials: State of the Art

Controlling dispersion of axonal regeneration using a multichannel collagen nerve conduit

Di̇ş Heki̇mli̇ği̇nde Peri̇feri̇k Si̇ni̇r Yaralanmalari Ve Tedavi̇si̇

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