Synthetic Parathyroid Hormone May Augment Bone Volume in Autogenous Grafts: A Study in Rats

Santos, Rodrigo A. B. dos; Ferreira, Marcelo Simão; Mafra, Carlos Eduardo Secco; Holzhausen, Marinella; Lima, Luiz Antônio Pugliesi Alves de; Pannuti, Cláudio Mendes; Neto, João Batista César

doi:10.1902/jop.2015.140638

Cited by 7 publications

(9 citation statements)

References 46 publications

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“…Many animal studies have found PTH to be effective in not only long bones,(Jahng & Kim, ; Kakar et al, ; Kim & Jahng, ) but also calvarial defect models(Andreassen & Cacciafesta, ; dos Santos et al, ; Sheyn et al, ) and the mandible. (Tang et al, ) Takahata, Awad, O'Keefe, Bukata, and Schwarz () reviewed that PTH was effective in both endochondral and intramembranous bone healing.…”

Section: Discussionmentioning

confidence: 99%

“…Many animal studies have found PTH to be effective in not only long bones, (Jahng & Kim, 2000;Kakar et al, 2007;Kim & Jahng, 1999) but also calvarial defect models (Andreassen & Cacciafesta, 2004;dos Santos et al, 2016;Sheyn et al, 2013) and the mandible. However, several studies have shown that teriparatide may have different effects on different skeletal sites (Iida-Klein et al, 2002;Lindsay et al, 1997).…”

Section: Discussionmentioning

confidence: 99%

“…The second consideration is the grafted site and material. Previous studies of the effect of PTH at the bone graft site employed allografts or autografts of the long bone (Daugaard et al, 2011;Takahata, Schwarz, Chen, O'Keefe, & Awad, 2012b), spine fusion (Abe et al, 2007), and calvarial defects (dos Santos et al, 2016;Sheyn et al, 2013). Huh et al (2017) is the only previous study to have investigated the effect of PTH on the sinus bone graft model.…”

Section: Discussionmentioning

confidence: 99%

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Effect of teriparatide on early sinus graft healing in the ovariectomized rabbit

Dam

Jung

Park

et al. 2020

Clinical Oral Implants Res

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Objectives The purpose of this study was to determine the effect of administering intermittent parathyroid hormone 1–34 [teriparatide, (PTH)] on the maxillary sinus lift and bone grafting in osteoporotic rabbits induced by ovariectomy and glucocorticoid. Materials and methods Ovariectomies were performed on 20 female New Zealand white rabbits that were randomly divided into two groups: (a) the PTH group (n = 10), in which 10 μg kg−1 day−1 PTH was injected subcutaneously 5 days a week for 5 weeks (from 1 week before until 4 weeks after sinus surgery), and (b) the saline group (n = 10), in which saline substituted PTH at the same dose, mode of administration, and duration. Bone grafting with bovine bone mineral was augmented into 13 sinuses, and bone grafts and implants were simultaneously performed in seven sinuses, in both groups. Animals were sacrificed at 4 weeks after surgery. To determine whether PTH was an effective treatment for osteoporosis, we measured the bone mineral density (BMD) of the right femur using micro‐computed tomography and performed radiographic and histometric analyses of the maxillary sinus surgery site. The Mann–Whitney test was used for statistical analysis. Results It was found that BMD increased in the femur, whereas none of the radiographic and histometric parameters differed significantly between the groups in the sinus, while there were large interindividual variations within groups. Conclusions These findings suggest that intermittent PTH does not promote new bone formation in the augmented maxillary sinus of ovariectomized rabbits.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Effect of teriparatide on early sinus graft healing in the ovariectomized rabbit

Dam

Jung

Park

et al. 2020

Clinical Oral Implants Res

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“…In other animal studies, PTH stimulated distraction osteogenesis in rabbits [ 18 ] and allograft integration in calvarial bone defects in mice [ 19 ]. Animal studies related to dental effects found that PTH stimulated healing after bone graft on extraction sockets [ 20 ] and calvarial bone autografts on the mandible in rats [ 21 ]. However, studies of the effect of PTH on bone grafts are still deficient, and PTH has not been evaluated previously in sinus augmentation.…”

Section: Introductionmentioning

confidence: 99%

“…Based on previous studies that were mentioned above, it is expected that intermittent PTH could stimulate the bone regeneration after maxillary sinus augmentation. Several studies performed in maxillofacial region of rabbit or rat showed especially that PTH increased jaw mineral density in rabbit [ 29 ], increased volume of calvarial autograft on mandible in rat [ 21 ], and increased bone fill of graft on extraction socket in rat [ 20 ]. These might support our hypothesis.…”

Section: Introductionmentioning

confidence: 99%

Parathyroid Hormone (1-34) Might Not Improve Early Bone Healing after Sinus Augmentation in Healthy Rabbits

Huh

Jung

Park

et al. 2017

BioMed Research International

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Purpose. This study evaluated the effect of administering intermittent parathyroid hormone [PTH (1-34), henceforth PTH] on the early-stage bone healing of maxillary sinus augmentation in healthy rabbits. Materials and Methods. Bovine bone mineral was grafted on the sinuses of 20 female New Zealand white rabbits. The animals were randomly divided into two groups, PTH (n = 10) or saline (n = 10), in which either PTH or saline was injected subcutaneously 5 days a week for 2 weeks. Half of the animals in each group were killed at 2 weeks postoperatively and the other half were killed at 4 weeks postoperatively. The dosage of PTH was 10 μg/kg/day. Radiographic and histomorphometric analyses were performed. Result. The new bone area (NBA) did not differ significantly between the PTH and saline groups. The NBA in the PTH group in the total augmented area and in the demarcated window, center, and Schneiderian membrane regions increased significantly from 2 to 4 weeks. The number of osteoclasts decreased significantly from 2 to 4 weeks in both groups, with no difference between the two groups. Conclusion. Intermittent PTH might not stimulate new bone formation in healthy rabbits during the first 4 weeks of healing.

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Effects of local single dose administration of parathormone on the early stages of osseointegration: A pre‐clinical study

et al. 2022

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The present study aimed to evaluate the effect of parathormone (PTH) administered directly to the implant's surface prior to insertion, using a large translational animal model. Sixty titanium implants were divided into four groups: (i) Collagen, control group, where implants were coated with Type‐I Bovine‐collagen, and three experimental groups, where implants received varying doses of PTH: (ii) 12.5, (iii) 25, and (iv) 50 μg, prior to placement. Fifteen female sheep (~2 years old, weighing ~65 kg) received four implants in an interpolated fashion in C3, C4 or C5 vertebral bodies. After 3‐, 6‐ and 12‐weeks, samples were harvested, histologically processed, qualitatively and quantitatively assessed for bone‐to‐implant contact (BIC) and bone area fraction occupancy (BAFO). BIC yielded lower values at 6‐weeks for 50 μg relative to the control group, with no significant differences, when compared to the 12.5‐ and 25‐μg. No significant differences were detected at 6‐weeks between collagen, 12.5‐ and 25‐μg groups. At 3‐ and 12‐weeks, no differences were detected for BIC among PTH groups. With respect to BAFO, no significant differences were observed between the control and experimental groups independent of PTH concentration and time in vivo. Qualitative observations at 3‐weeks indicated the presence of a more mature bone near the implant's surface with the application of PTH, however, no significant differences in new bone formation or healing patterns were observed at 6‐ and 12‐weeks. Single local application of different concentrations of PTH on titanium implant's surface did not influence the osseointegration at any time‐point evaluation in low‐density bone.

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Synthetic Parathyroid Hormone May Augment Bone Volume in Autogenous Grafts: A Study in Rats

Abstract: Systemic administration of PTH(1-34) augmented bone volume in autogenous grafts.

Cited by 7 publications

References 46 publications

Effect of teriparatide on early sinus graft healing in the ovariectomized rabbit

Effect of teriparatide on early sinus graft healing in the ovariectomized rabbit

Parathyroid Hormone (1-34) Might Not Improve Early Bone Healing after Sinus Augmentation in Healthy Rabbits

Effects of local single dose administration of parathormone on the early stages of osseointegration: A pre‐clinical study

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