Synthetic Scaffold/Dental Pulp Stem Cell (DPSC) Tissue Engineering Constructs for Bone Defect Treatment: An Animal Studies Literature Review

Lorusso, Felice; Inchingolo, Francesco; Dipalma, Gianna; Postiglione, Francesca; Fulle, Stefania

doi:10.3390/ijms21249765

Cited by 32 publications

(27 citation statements)

References 95 publications

(247 reference statements)

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“…Similar to DPSCs, SHED derive from dental pulp. However, due to the developmental differences between deciduous and permanent teeth, SHED express higher levels of genes related to stemness (OCT4, SOX2, NANOG, and REX-1) compared to DPSCs, retaining a higher plasticity through passaging in vitro [ 45 , 46 ]. SHED are highly proliferative and capable of differentiating into a variety of cell types, such as neural cells, osteoblasts, chondrocytes, and adipocytes [ 13 ].…”

Section: Oral Mscsmentioning

confidence: 99%

“…The potential of DPSCs for periodontal regeneration may be questionable because of their limited capacity to form cementum [43,44]. A recent revision of the literature reported that DPSCs on synthetic scaffolds are useful to treat bone defects, showing encouraging results of early new bone formation in preclinical animal studies [45].…”

Section: Dental Pulp Stem Cells (Dpscs)mentioning

confidence: 99%

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Oral Cavity as a Source of Mesenchymal Stem Cells Useful for Regenerative Medicine in Dentistry

et al. 2021

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The use of mesenchymal stem cells (MSCs) for regenerative purposes has become common in a large variety of diseases. In the dental and maxillofacial field, there are emerging clinical needs that could benefit from MSC-based therapeutic approaches. Even though MSCs can be isolated from different tissues, such as bone marrow, adipose tissue, etc., and are known for their multilineage differentiation, their different anatomical origin can affect the capability to differentiate into a specific tissue. For instance, MSCs isolated from the oral cavity might be more effective than adipose-derived stem cells (ASCs) for the treatment of dental defects. Indeed, in the oral cavity, there are different sources of MSCs that have been individually proposed as promising candidates for tissue engineering protocols. The therapeutic strategy based on MSCs can be direct, by using cells as components of the tissue to be regenerated, or indirect, aimed at delivering local growth factors, cytokines, and chemokines produced by the MSCs. Here, the authors outline the major sources of mesenchymal stem cells attainable from the oral cavity and discuss their possible usage in some of the most compelling therapeutic frontiers, such as periodontal disease and dental pulp regeneration.

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Section: Oral Mscsmentioning

confidence: 99%

Section: Dental Pulp Stem Cells (Dpscs)mentioning

confidence: 99%

Oral Cavity as a Source of Mesenchymal Stem Cells Useful for Regenerative Medicine in Dentistry

et al. 2021

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“…In vivo tissue formation ability comparison among MFSCs Bone JBMSCs [197]>DFSCs [152], SCAP [131], SHED [163,170]>DPSCs [107,109], PDLSCs [3,69,77] 5 Stem Cells International cocultured with B cells, they inhibited the production of IgG, IgM, and IgA and suppressed the proliferation of B cells by increasing the expression of PD1 and PD-L1 [69]. HPDLSCs also mediate the macrophage polarization.…”

Section: Tissuementioning

confidence: 99%

“…Among MSCs discovered up until now, DPSCs have showed high mitochondrial respiratory ability, which is an indicator of the initiation of the differentiation to odontoblasts and osteoblast [ 108 ]. Accompanied with a synthetic scaffold, DPSCs have successfully increased new bone formation in rats, rabbits, sheep, and swine animal models [ 109 ]. Moreover, Wang et al have invented the DPSC rejection medicine to regenerate alveolar bone and it has recently been placed in phase II clinical trials [cde.org.cn identifier: CXSL1700137 ].…”

Section: Dental Pulp Stem Cellsmentioning

confidence: 99%

Maxillofacial-Derived Mesenchymal Stem Cells: Characteristics and Progress in Tissue Regeneration

Yan

Mohammed

et al. 2021

Stem Cells International

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Maxillofacial-derived mesenchymal stem cells (MFSCs) are a particular collective type of mesenchymal stem cells (MSCs) that originate from the hard and soft tissue of the maxillofacial region. Recently, many types of MFSCs have been isolated and characterized. MFSCs have the common characteristics of being extremely accessible and amazingly multipotent and thus have become a promising stem cell resource in tissue regeneration. However, different MFSCs can give rise to different cell lineages, have different advantages in clinical use, and regulate the immune and inflammation microenvironment through paracrine mechanisms in different ways. Hence, in this review, we will concentrate on the updated new findings of all types of MFSCs in tissue regeneration and also introduce the recently discovered types of MFSCs. Important issues about proliferation and differentiation in vitro and in vivo, up-to-date clinical application, and paracrine effect of MFSCs in tissue regeneration will also be discussed. Our review may provide a better guide for the clinical use of MFSCs and further direction of research in MFSC regeneration medicine.

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“…Indeed, functional CB 1 receptors have also been reported in human odontoblasts [ 96 ]. Cannabinoid treatment of rat odontoblasts has been shown to promote the formation of “reparative dentin” by modulating extracellular Ca 2+ entry [ 97 ], which might be the mechanism for CB 1 -mediated dental pulp tissue repair via the matrix metalloproteinase–2 activation in dental pulp cells [ 98 , 99 , 100 , 101 , 102 ].…”

Section: Introductionmentioning

confidence: 99%

Cannabinoids Drugs and Oral Health—From Recreational Side-Effects to Medicinal Purposes: A Systematic Review

Bellocchio

Inchingolo

et al. 2021

IJMS

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Background: marijuana, the common name for cannabis sativa preparations, is one of the most consumed drug all over the world, both at therapeutical and recreational levels. With the legalization of medical uses of cannabis in many countries, and even its recreational use in most of these, the prevalence of marijuana use has markedly risen over the last decade. At the same time, there is also a higher prevalence in the health concerns related to cannabis use and abuse. Thus, it is mandatory for oral healthcare operators to know and deal with the consequences and effects of cannabis use on oral cavity health. This review will briefly summarize the components of cannabis and the endocannabinoid system, as well as the cellular and molecular mechanisms of biological cannabis action in human cells and biologic activities on tissues. We will also look into oropharyngeal tissue expression of cannabinoid receptors, together with a putative association of cannabis to several oral diseases. Therefore, this review will elaborate the basic biology and physiology of cannabinoids in human oral tissues with the aim of providing a better comprehension of the effects of its use and abuse on oral health, in order to include cannabinoid usage into dental patient health records as well as good medicinal practice. Methods: the paper selection was performed by PubMed/Medline and EMBASE electronic databases, and reported according to the PRISMA guidelines. The scientific products were included for qualitative analysis. Results: the paper search screened a total of 276 papers. After the initial screening and the eligibility assessment, a total of 32 articles were considered for the qualitative analysis. Conclusions: today, cannabis consumption has been correlated to a higher risk of gingival and periodontal disease, oral infection and cancer of the oral cavity, while the physico-chemical activity has not been completely clarified. Further investigations are necessary to evaluate a therapeutic efficacy of this class of drugs for the promising treatment of several different diseases of the salivary glands and oral diseases.

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Synthetic Scaffold/Dental Pulp Stem Cell (DPSC) Tissue Engineering Constructs for Bone Defect Treatment: An Animal Studies Literature Review

Cited by 32 publications

References 95 publications

Oral Cavity as a Source of Mesenchymal Stem Cells Useful for Regenerative Medicine in Dentistry

Oral Cavity as a Source of Mesenchymal Stem Cells Useful for Regenerative Medicine in Dentistry

Maxillofacial-Derived Mesenchymal Stem Cells: Characteristics and Progress in Tissue Regeneration

Cannabinoids Drugs and Oral Health—From Recreational Side-Effects to Medicinal Purposes: A Systematic Review

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