Syringin monohydrate

Yin, Ren-Jie; Wang, Xiao-Bing; Kong, Ling–Yi

doi:10.1107/s1600536806048008

Cited by 1 publication

(1 citation statement)

References 4 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…3). A chemical structure was finally confirmed by comparing its spectral data with those reported in the literatures (Yin et al, 2006). (25)(26)(27)(28)(29)(30)(31)(32)(33)(34)(35) for 24 h. Cell viability was estimated by MTT assay.…”

Section: Resultsmentioning

confidence: 99%

Syringin from stem bark of Fraxinus rhynchophylla protects Aβ(25–35)-induced toxicity in neuronal cells

Yang

Kim

et al. 2010

Arch. Pharm. Res.

View full text Add to dashboard Cite

The medicinal herb Jinpi, derived from the dried stem barks of Fraxinus rhynchophylla belonging to Oleaceae is widely used as a variety of Korean folk remedies for anti-inflammatory, febricide, antidiarrhea, and antileukorrhea diseases. In the course of screening antidementia agents from natural products, F. rhynchophylla showed significant inhibitory activity toward Abeta(25-35)-induced neuronal cell death. An active principle was isolated and identified as syringin. When the neuroblastoma cells were exposed to 50 microM Abeta(25-35), 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) reduction rate (survival rate) decreased to 60.21 +/- 2.16% over control while syringin treated ones recovered cell viability up to 79.12 +/- 1.39% at 20 microM. In addition, 20 microM syringin almost completely removed Abeta(25-35)-induced reactive oxygen species. The neuroprotective effect of syringin seemed to be originated from the reduction of apoptosis since decrease in caspase-3 activity and expression, reduction in cleaved PARP, and DNA fragmentation were observed. These results suggest that F. rhynchophylla and syringin are expected to be useful for preventing Abeta(25-35)-induced neuronal cell damage.

show abstract

Section: Resultsmentioning

confidence: 99%