Abstract:Microtubules are ubiquitous cytoskeletal polymers with essential functions in chromosome segregation, intracellular transport and cellular morphogenesis. End-binding proteins (EBs) form the nodes of intricate microtubule plus-end interaction networks. Which EB binding partners are most critical for cell division, and how cells manage to organize a microtubule cytoskeleton in the absence of an EB protein, are open questions. Here we demonstrate that the budding yeast EB protein Bim1 executes its key mitotic fun… Show more
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