Systematic analysis of prognostic significance, functional enrichment and immune implication of STK10 in acute myeloid leukemia

Abstract

Background Despite deeper understanding of the genetic landscape of acute myeloid leukemia (AML), the improvement of survival is still a great challenge. STK10 is overexpressed in several cancers with functions varying according to cancer types. But the functions of STK10 in AML has never been reported. Methods We analyzed the expression, prognosis and potential functions of STK10 utilizing public web servers. Metascape and the String database were used for functional and protein–protein interaction analyses. Results We found STK10 was enriched in blood & immune cells and overexpressed in AML. High STK10 expression was associated with poor overall survival, which was also identified in the subgroups of patients ≤ 60 years old and patients with non-high-risk cytogenetics. We demonstrated genes associated with STK10 were enriched in blood, spleen and bone marrow, influencing the immune function and biological process of AML. ITGB2 and ITGAM might directly interact with STK10 and were associated with poor prognosis. Besides, STK10 was associated with the infiltration of immune cells and immune checkpoints, like HLA-E, CD274 and GAL-9. Conclusions The present study was the original description of STK10 in AML and set the stage for developing STK10 as a new prognostic marker or therapeutic target for AML.

ITGAM sustains MAPK signaling and serves as an adverse prognostic factor and therapeutic target in acute myeloid leukemia

“…The aberrant expression of multiple genes is now recognized as a major factor in AML pathogenesis ( 16 , 17 ). For instance, serine/threonine kinase 10 (STK10) is upregulated in AML and is linked to poor prognosis, while ITGAM and integrin beta 2 (ITGB2) expression are positively correlated with STK10 levels and reduced OS in AML ( 18 ).…”

Comprehensive bioinformatic analysis of the expression and prognostic significance of TSC22D domain family genes in adult acute myeloid leukemia

“…Dysregulated activation of TYK2 in cancers may lead to hyperactive JAK/STATs signal, which may play an important role in the occurrence and development of cancers [ 38 ]. The prognosis of AML patients with expressing high levels of STK10 was poor, which could severe as a new prognostic biomarker for AML [ 39 ].…”

Identification of novel genetic loci for risk of multiple myeloma by functional annotation

“…In various lymphoid cells rs28199-G is associated with an increased expression of STK10 . Overexpression of STK10 has been reported in several cancer types, including acute myeloid leukemia (AML), another blood malignancy [ 13 , 14 ].…”