Systematic computational toxicity analysis of the ozonolytic degraded compounds of azo dyes: Quantitative structure-activity relationship (QSAR) and adverse outcome pathway (AOP) based approach

Reddy Ramireddy, Venkata Sai; Kurakula, Rakshitha; Velayudhaperumal Chellam, Padmanaban; James, Anina; van Hullebusch, Eric D.

doi:10.1016/j.envres.2023.116142

Cited by 12 publications

(1 citation statement)

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“… 100 Despite clear hazard information for a subset of AAs, many have limited information on toxicity. Novel techniques incorporating computational toxicology 130 , 131 or proteome profiling 132 have improved available information for azo dyes and some AAs, and there is clear potential for the further application of such techniques for less studied AAs, such as the metabolites of brominated azo dyes. 132 …”

Section: Hazards and Regulationmentioning

confidence: 99%

Tracking Aromatic Amines from Sources to Surface Waters

Edebali,

Krupčíková,

Goellner

et al. 2024

Environ. Sci. Technol. Lett.

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This review examines the environmental occurrence and fate of aromatic amines (AAs), a group of environmental contaminants with possible carcinogenic and mutagenic effects. AAs are known to be partially responsible for the genotoxic traits of industrial wastewater (WW), and AA antioxidants are acutely toxic to some aquatic organisms. Still, there are gaps in the available data on sources, occurrence, transport, and fate in domestic WW and indoor environments, which complicate the prevention of adverse effects in aquatic ecosystems. We review key domestic sources of these compounds, including cigarette smoke and grilled protein-rich foods, and their presence indoors and in aquatic matrices. This provides a basis to evaluate the importance of nonindustrial sources to the overall environmental burden of AAs. Appropriate sampling techniques for AAs are described, including copper-phthalocyanine trisulfonate materials, XAD resins in solid-phase extraction, and solid-phase microextraction methods, which can offer insights into AA sources, transport, and fate. Further discussion is provided on potential progress in the research of AAs and their behavior in an aim to support the development of a more comprehensive understanding of their effects and potential environmental risks.

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