Systematic Mendelian randomization study of the effect of gut microbiome and plasma metabolome on venous thromboembolism
Pengfei Cheng,
Yuan He,
junjie hu
et al.
Abstract:Background
Although there is considerable evidence suggesting a link between gut microbiota (GM) composition and venous thromboembolism (VTE)/deep vein thrombosis (DVT)/pulmonary embolism (PE), population-level studies that can establish a causal relationship are currently lacking.
Methods
Using two-sample Mendelian randomization (MR) approach was used to examine the causal effects of 211 GM and 489 plasma metabolites on VTE/PE/DVT. We employed instrumental variables comprised of single nucleotide polymorphi… Show more
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