2013
DOI: 10.1016/j.chroma.2013.03.008
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Systematic optimisation and evaluation of on-line, off-line and stop-flow comprehensive hydrophilic interaction chromatography×reversed phase liquid chromatographic analysis of procyanidins, Part I: Theoretical considerations

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Cited by 65 publications
(65 citation statements)
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“…Although the stop-flow mode seems to be convenient to increase 2 TG [39][40][41], it is time consuming [40] even with UHPLC conditions in the 2 D [41,42], and, in addition, it requires additional hardware. Moreover, axial dispersion may be a critical issue, particularly for the most retained compounds, thereby leading to significant peak band broadening [8].…”
Section: The Quest For Large Separation Power In On-line Lc X Lc Applmentioning
confidence: 99%
“…Although the stop-flow mode seems to be convenient to increase 2 TG [39][40][41], it is time consuming [40] even with UHPLC conditions in the 2 D [41,42], and, in addition, it requires additional hardware. Moreover, axial dispersion may be a critical issue, particularly for the most retained compounds, thereby leading to significant peak band broadening [8].…”
Section: The Quest For Large Separation Power In On-line Lc X Lc Applmentioning
confidence: 99%
“…For off-line method development the first dimension sampling time is chosen for an acceptable degree of under-sampling based on measured peak widths, whereas the second dimension cycle time is chosen to provide the required resolution in this dimension. Especially 1 (in other words, the number of fractions), but also 2 directly determines the total analysis time in on-line LC×LC [127]. Depending on the mobile phase properties and column dimensions and flow rates in both dimensions, the evaporation of solvent might be required prior to re-injection onto the second dimension column.…”
Section: Methods Development and Instrumental Design In Lc×lcmentioning
confidence: 99%
“…the product of the first dimension flow rate and the sampling time), splitting before the second dimension column may be used in on-line and stop-flow LC×LC [127,130,131]. [127].…”
Section: Methods Development and Instrumental Design In Lc×lcmentioning
confidence: 99%
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