Systematic optimization, characterization of Mycophenolic acid loaded nanostructured lipid carrier embedd ed nanogel for improved permeation and in vivo antipsoriatic activity

Kesharwani, Payal; Bisht, Akansha; Handa, Mayank; Shukla, Rahul; Kesari, Mahendra Kumar; Paliwal, Shailendra; Paliwal, Sarvesh; Sharma, Swapnil

doi:10.1016/j.jddst.2023.105088

Journal of Drug Delivery Science and Technology

2023

DOI: 10.1016/j.jddst.2023.105088

|View full text |Cite

Systematic optimization, characterization of Mycophenolic acid loaded nanostructured lipid carrier embedd ed nanogel for improved permeation and in vivo antipsoriatic activity

Payal Kesharwani,

Akansha Bisht,

Mayank Handa

et al.

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2024

Publication Types

Select...

Article2

Relationship

Self Cite0

Independent2

Authors

Journals

Cited by 2 publications

References 68 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

Tissue regeneration properties of hydrogels derived from biological macromolecules: A review

Kesharwani,

Alexander,

Shukla

et al. 2024

International Journal of Biological Macromolecules

View full text Add to dashboard Cite

Tissue regeneration properties of hydrogels derived from biological macromolecules: A review

Kesharwani,

Alexander,

Shukla

et al. 2024

International Journal of Biological Macromolecules

View full text Add to dashboard Cite

Comparative Study of pH-Responsive and Aggregation Stability of Bosutinib-Loaded Nanogels Comprising Gelatin Methacryloyl, Carboxymethyl Dextran, and Hyaluronic Acid for Controlled Drug Delivery in Colorectal Cancer: An Extensive In Vitro Investigation

Bhattacharya,

Bagade,

Sangave

et al. 2024

Biomacromolecules

View full text Add to dashboard Cite

This study investigates the use of pH-responsive nanogels for delivering Bosutinib (BOSU) in colon cancer treatment. Nanogels were formulated using three polymers: hyaluronic acid (HA), carboxymethyl dextran (CMD), and gelatin methacryloyl (GelMA). These nanogels achieved high drug entrapment efficiencies (80−90%) through polymer mixing with BOSU, followed by EDC/NHS cross-linking and sonication. The nanogels were stable, with negative zeta potentials (−20 to −30 mV) and particle sizes between 100 and 200 nm. Fourier-transform infrared analysis confirmed successful methacrylation in GelMA nanogels. Sustained BOSU release at pH 5.0 was observed, resembling tumor environments, compared to slower release at normal pH (7.4). Cytotoxicity tests showed 70−80% cell survival reduction in HCT116 colon cancer cells at higher doses, and GelMA-BOSU nanogels notably reduced cell migration. Antiangiogenic effects were confirmed in a chick chorioallantoic membrane model, highlighting the potential of these nanogels for targeted BOSU delivery in colon cancer therapy.

show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

customersupport@researchsolutions.com

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

Systematic optimization, characterization of Mycophenolic acid loaded nanostructured lipid carrier embedd ed nanogel for improved permeation and in vivo antipsoriatic activity

Cited by 2 publications

References 68 publications

Tissue regeneration properties of hydrogels derived from biological macromolecules: A review

Tissue regeneration properties of hydrogels derived from biological macromolecules: A review

Comparative Study of pH-Responsive and Aggregation Stability of Bosutinib-Loaded Nanogels Comprising Gelatin Methacryloyl, Carboxymethyl Dextran, and Hyaluronic Acid for Controlled Drug Delivery in Colorectal Cancer: An Extensive In Vitro Investigation

Contact Info

Product

Resources

About