Systematic review and consensus definitions for standardised endpoints in perioperative medicine: postoperative cancer outcomes

Abstract

Standardised endpoints in clinical outcomes studies will support benchmarking and pooling (meta-analysis) of trials. It is therefore recommended that one or more of these consensus-derived endpoints should be considered for inclusion in clinical trials evaluating a causal effect of anaesthesia-analgesia technique on oncological outcomes.

Anaesthesia and risk of cancer recurrence after surgery: a plea for a multidisciplinary vision

“…EditordWe read with interest the articles in the March 2018 issue of the British Journal of Anaesthesia regarding medication errors in the paediatric population, 1e4 and agree with Burton and colleagues 3 and Kaufmann and colleagues 4 that change should occur. But are we as a specialty resistant to change?…”

“…In conclusion, the article of Buggy and colleagues 3 is an important piece of work, but more needs to be done. A multidisciplinary collaboration could help improve the quality, and hopefully the quantity, of perioperative research by mutual enrichment between the different involved disciplines.…”

“…As mentioned in the 2014 consensus statement, 2 multidisciplinary input is crucial in this area, not only in patient care but also in research, to optimise expertise in both anaesthesia and cancer research. 3 A lot of work has already been done by many international organisations active in cancer research, including by the European Organization for Research and Treatment on Cancer, with a large overlap with the goals of the present work. With this multidisciplinary collaboration, important progress will include fundamental issues.…”

“…Likewise, in their prospective incident monitoring study, Gariel and colleagues 2 describe error processes that have been previously reported, and reiterate changes to practice that have previously been suggested 5 to improve medication safety in paediatric anaesthesia. Had these strategies been implemented into current practice, numerous errors mentioned in both studies 2,3 could have potentially been prevented.…”

Pediatric perioperative outcomes: Protocol for a systematic literature review and identification of a core outcome set for infants, children, and young people requiring anesthesia and surgery

“…Final recommendations are based on identifying items critical for inclusion, plus rating the face and content validity, reliability, and feasibility of the specific endpoints or measurement tools to establish the Core Outcome Measures in Perioperative and Anaesthetic Care (COMPAC) . Results have been published across several predetermined domains that include clinical indicators, infection and sepsis, renal endpoints, postoperative cancer outcomes, pulmonary complications, blood loss and transfusion, patient comfort, and patient‐centered outcomes …”