Systematic review of megestrol acetate in the treatment of anorexia-cachexia syndrome

López, Antonio Pascual; Figuls, Marta Roqué i; Urrútia, Gerard; Berenstein, Etelvina Graciela; Pasies, Beatriz Almenar; Alegre, Miquel Balcells; Herdman, Michael

doi:10.1016/j.jpainsymman.2003.09.007

Cited by 156 publications

(41 citation statements)

References 36 publications

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“…A systematic review demonstrated the safety and efficacy of megestrol acetate in treating cachexia for patients with cancer. 211 However, a second systematic review and meta-analysis of 4 studies revealed no benefit of progestational steroids compared with placebo for treatment of CRF ( z score=0.78; P =.44). 138,212 …”

Section: Interventions For Patients At the End Of Lifementioning

confidence: 99%

Cancer-Related Fatigue, Version 2.2015

Berger¹,

Mooney²,

Alvarez-Perez³

et al. 2015

J Natl Compr Canc Netw

676

511

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Cancer-related fatigue is defined as a distressing, persistent, subjective sense of physical, emotional, and/or cognitive tiredness or exhaustion related to cancer or cancer treatment that is not proportional to recent activity and interferes with usual functioning. It is one of the most common side effects in patients with cancer. Fatigue has been shown to be a consequence of active treatment, but it may also persist into posttreatment periods. Furthermore, difficulties in end-of-life care can be compounded by fatigue. The NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines) for Cancer-Related Fatigue provide guidance on screening for fatigue and recommendations for interventions based on the stage of treatment. Interventions may include education and counseling, general strategies for the management of fatigue, and specific nonpharmacologic and pharmacologic interventions. Fatigue is a frequently underreported complication in patients with cancer and, when reported, is responsible for reduced quality of life. Therefore, routine screening to identify fatigue is an important component in improving the quality of life for patients living with cancer.

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Section: Interventions For Patients At the End Of Lifementioning

confidence: 99%

Cancer-Related Fatigue, Version 2.2015

Berger¹,

Mooney²,

Alvarez-Perez³

et al. 2015

J Natl Compr Canc Netw

676

511

View full text Add to dashboard Cite

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“…Anorexia has been shown to be treatable with androgenic and anabolic steroids including nadrolone, decanoate, and oxandrolone [105–107]. …”

Section: Management For Nutrition-related Complicationsmentioning

confidence: 99%

Protein calorie malnutrition, nutritional intervention and personalized cancer care

et al. 2017

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Cancer patients often experience weight loss caused by protein calorie malnutrition (PCM) during the course of the disease or treatment. PCM is expressed as severe if the patient has two or more of the following characteristics: obvious significant muscle wasting, loss of subcutaneous fat; nutritional intake of <50% of recommended intake for 2 weeks or more; bedridden or otherwise significantly reduced functional capacity; weight loss of >2% in 1 week, 5% in 1 month, or 7.5% in 3 months. Cancer anorexiacachexia syndrome (CACS) is a multifactorial condition of advanced PCM associated with underlying illness (in this case cancer) and is characterized by loss of muscle with or without loss of fat mass. Cachexia is defined as weight loss of more than 5% of body weight in 12 months or less in the presence of chronic disease. Hence with a chronic illness on board even a small amount of weight loss can open the door to cachexia. These nutritional challenges can lead to severe morbidity and mortality in cancer patients. In the clinic, the application of personalized medicine and the ability to withstand the toxic effects of anti-cancer therapies can be optimized when the patient is in nutritional homeostasis and is free of anorexia and cachexia. Routine assessment of nutritional status and appropriate intervention are essential components of the effort to alleviate effects of malnutrition on quality of life and survival of patients.

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“…In several clinical trials, these compounds have been found to improve appetite and increase body fat-free mass [15,16].…”

Section: Progestational Drugsmentioning

confidence: 99%