Systematic review of ratios between disease /health periodontitis modulators and meta-analysis of their levels in gingival tissue and biological fluids

Caldeira, François Isnaldo Dias; Hidalgo, Marco Antonio Rimachi; Dias, Marina Lara De Carli; Scarel‐Caminaga, Raquel Mantuaneli; Pigossi, Suzane Cristina

doi:10.1016/j.archoralbio.2021.105147

Cited by 16 publications

(12 citation statements)

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“…RANKL binds to the receptor activator of NF-kB (RANK) receptor, which is expressed on the surface of osteoclast progenitor cells [9]. RANKL/RANK signalling regulates osteoclast formation, activation and survival in normal bone remodelling, as well as in a variety of pathological conditions characterised by increased bone turnover [9], including periodontitis-a recent systematic review and meta-analysis revealed that RANKL mRNA levels were significantly higher in gingival tissue as well as protein levels in the gingival crevicular fluid (GCF) of individuals suffering from periodontitis [10]. Osteoprotegerin (OPG), which functions as a decoy receptor of RANKL and can be released from osteoblasts as well as periodontal ligament (PDL) fibroblasts, protects bone from excessive resorption by binding to RANKL and preventing its binding to the membrane-bound RANK receptor on osteoclast precursor cells and thus their differentiation and fusion to active bone-resorbing osteoclasts [9].…”

Section: Introductionmentioning

confidence: 99%

“…Osteoprotegerin (OPG), which functions as a decoy receptor of RANKL and can be released from osteoblasts as well as periodontal ligament (PDL) fibroblasts, protects bone from excessive resorption by binding to RANKL and preventing its binding to the membrane-bound RANK receptor on osteoclast precursor cells and thus their differentiation and fusion to active bone-resorbing osteoclasts [9]. In this regard, it is not the absolute expression of RANKL that is decisive for osteoclast activity, but rather the ratio of RANKL to OPG expression, both for orthodontic tooth movement [2], which requires controlled osteoclastogenesis and osteoclast activity in the direction of tooth movement, as well as periodontitis [10,11]. A recent systematic review reports that (pre)clinical evidence regarding periapical as well as periodontal lesions hints at an increase of the RANKL/OPG ratio as a primary determinant of osteolytic activity in the etiopathology of periodontitis, whereas a decreased RANKL/OPG ratio seems to be associated with inactive lesions [11].…”

Section: Introductionmentioning

confidence: 99%

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Myeloid HIF1α Is Involved in the Extent of Orthodontically Induced Tooth Movement

et al. 2021

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During orthodontic tooth movement, transcription factor hypoxia-inducible factor 1α (HIF1α) is stabilised in the periodontal ligament. While HIF1α in periodontal ligament fibroblasts can be stabilised by mechanical compression, in macrophages pressure application alone is not sufficient to stabilise HIF1α. The present study was conducted to investigate the role of myeloid HIF1α during orthodontic tooth movement. Orthodontic tooth movement was performed in wildtype and Hif1αΔmyel mice lacking HIF1α expression in myeloid cells. Subsequently, µCT images were obtained to determine periodontal bone loss, extent of orthodontic tooth movement and bone density. RNA was isolated from the periodontal ligament of the control side and the orthodontically treated side, and the expression of genes involved in bone remodelling was investigated. The extent of tooth movement was increased in Hif1αΔmyel mice. This may be due to the lower bone density of the Hif1αΔmyel mice. Deletion of myeloid Hif1α was associated with increased expression of Ctsk and Acp5, while both Rankl and its decoy receptor Opg were increased. HIF1α from myeloid cells thus appears to play a regulatory role in orthodontic tooth movement.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Myeloid HIF1α Is Involved in the Extent of Orthodontically Induced Tooth Movement

et al. 2021

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“…Similar results were reported by Stadler et al ( 2016 ) in their meta-analysis, where elevated levels of IL-6 were also observed. Caldeira et al ( 2021 ) evaluated gene expression of IL-1 and IL-6 in gingival tissues and relevant protein levels in gingival crevicular fluid, and confirmed a rise of both markers in the course of inflammation. A cross-sectional study by Ebersole et al ( 2013 ) conducted on 80 individuals has shown the significant elevation of MMP-8 and decrease of IFN-α in periodontitis patients compared to healthy persons (up to 13-fold and 9-fold, respectively).…”

Section: Markers Of the Diseasementioning

confidence: 88%

“…Studies conducted on animals proved that delivery of OPG inhibits resorption of the alveolar bone in an experimental ligature-induced model (Jin et al 2007 ). According to studies on humans, the RANKL/OPG ratio turned out to be a reliable marker of the processes occurring in periodontium (Caldeira et al 2021 ). Elevation of RANKL with simultaneous decrease of OPG is observed in periodontitis, whereas the opposite phenomenon occurs in healthy periodontium (Belibasakis and Bostanci 2012 ; Caldeira et al 2021 ) or during the healing process (López Roldán et al 2020 ).…”

Section: Markers Of the Diseasementioning

confidence: 99%

What Has Immunology Brought to Periodontal Disease in Recent Years?

Kowalski

Nowak

Górski

et al. 2022

Arch. Immunol. Ther. Exp.

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Recent decades have shed a new light on the pathomechanism of periodontal inflammation. While classic periodontology concentrates on biofilm control, oral hygiene improvement, professional tooth cleaning and surgical correction of damaged periodontal tissues, new aspects of the destruction mechanisms are being raised. Among them, the greatest attention is paid to the influence of host response on the clinical manifestations of the disease. Numerous studies have proved that the shift from gingivitis to periodontitis is not a simple progress of the disease, but an event occurring only in susceptible individuals. Susceptibility may result from appearance of local factors facilitating biofilm accumulation and/or maturation, or from systemic features, among which over-reaction and prolonged agitation of non-specific component of inflammatory response is crucial. The present paper summarizes the association between periodontology and immunology and updates the knowledge accrued mostly in the recent years. After a brief explanation of advances in understanding of the disease aetiology, the most studied and potentially viable immunological markers of periodontal disease are presented. Possible new therapeutic strategies, exploiting knowledge about the nature of host response—immunomodulation and reduction of chronic oxidative stress—are also presented.

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“…A DP nada mais é do que um processo inflamatório, comum e complexo, caracterizada pela destruição dos tecidos periodontais de suporte dentários, como osso alveolar e o ligamento periodontal. Apesar de a inflamação ter início por bactérias, a doença resulta da resposta inflamatória do hospedeiro que se desenvolve a fim de combater esse biofilme presente na cavidade bucal 6 . Nesse sentido, essa doença foi avaliada quanto a um papel potencial no desenvolvimento do diabetes mellitus gestacional (DMG), além de risco significativo de complicações do diabetes 7 .…”

Section: Introductionunclassified

Relação entre a Diabetes Mellitus Gestacional e a Doença Periodontal: uma Revisão Atual

et al. 2021

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A doença periodontal (DP) é um processo inflamatório, comum e complexo, caracterizada pela destruição dos tecidos periodontais de suporte, e foi avaliada quanto a um papel potencial no desenvolvimento do diabetes mellitus gestacional (DMG). O objetivo deste trabalho foi realizar um levantamento bibliográfico, sobre a relação entre a DMG e a DP. Foram realizadas buscas virtuais nas bases de dados PubMed/Medline até junho de 2021, e incluídos os estudos na língua inglesa, publicados nos últimos dez anos. Para tanto foram utilizados os seguintes descritores na língua inglesa: gestational diabetes e periodontal diseases. Dentro desta busca, foram encontrados 71 artigos, dos quais após o processo de triagem, foram excluídos 53 estudos por não responderem a pergunta norteadora. Assim, totalizando 18 pesquisas originais que compuseram esta revisão de literatura narrativa. Os estudos demonstraram que a periodontite atua como fator de risco para o desenvolvimento da DMG, e conhecer os determinantes sociais da saúde envolvidos no processo saúde-doença da doença periodontal, podem ajudar a estabelecer uma ligação entre estas comorbidades que afetam essa parcela da população.

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Systematic review of ratios between disease /health periodontitis modulators and meta-analysis of their levels in gingival tissue and biological fluids

Cited by 16 publications

References 63 publications

Myeloid HIF1α Is Involved in the Extent of Orthodontically Induced Tooth Movement

Myeloid HIF1α Is Involved in the Extent of Orthodontically Induced Tooth Movement

What Has Immunology Brought to Periodontal Disease in Recent Years?

Relação entre a Diabetes Mellitus Gestacional e a Doença Periodontal: uma Revisão Atual

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