Systematic review of serological methods used in prenatal screening of toxoplasmosis in pregnant women

Marques, Bruno; Andrade, Gláucia Manzan Queiroz de; Neves, Suzane Pretti Figueiredo; Pereira, Fernando Henrique; Talim, Mariza Cristina Torres

doi:10.5935/2238-3182.20150099

Cited by 5 publications

(7 citation statements)

References 42 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Symptoms suggestive of acute toxoplasmosis were observed in 22.1% of cases, consistent with reports in the literature, 3 which varies from 10% to 30%. 10 , 15 This emphasizes the importance of prenatal serological screening for toxoplasmosis, 3 but as there is still no national serological screening policy in Brazil for toxoplasmosis in prenatal care, 11 with lost opportunities for both diagnosis and prevention.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Toxoplasmosis in pregnancy: a clinical, diagnostic, and epidemiological study in a referral hospital in Rio de Janeiro, Brazil

Villar¹,

Neves

Louro³

et al. 2020

The Brazilian Journal of Infectious Diseases

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 99%

“… 10 The Brazilian Ministry of Health recommends serological screening during prenatal care, but thus far the municipal health services are responsible for defining the best strategy to be adopted. 11 …”

Section: Introductionmentioning

confidence: 99%

Toxoplasmosis in pregnancy: a clinical, diagnostic, and epidemiological study in a referral hospital in Rio de Janeiro, Brazil

Villar¹,

Neves

Louro³

et al. 2020

The Brazilian Journal of Infectious Diseases

View full text Add to dashboard Cite

“…The sera were considered positive if IgG and/or IgM antibodies were detected following the cut-off values provided by the manufacturer. Although indirect Enzyme Linked Immunosorbent Assay (ELISA) was found to be the most frequent serological method used for screening of toxoplasmosis in pregnant women [28], electrochemiluminescence immunoassay was found more sensitive and specific than ELISA [29, 30].…”

Section: Methodsmentioning

confidence: 99%

Prevalence and predictors of Toxoplasma gondii infection in pregnant women from Dhamar, Yemen

et al. 2019

View full text Add to dashboard Cite

BackgroundToxoplasmosis is a common and serious parasitic infection caused by the ubiquitous obligatory intracellular protozoan organism, Toxoplasma gondii. Although infection with T. gondii is usually asymptomatic in healthy individuals, it can lead to severe pathological effects in congenital cases and immunocompromised patients. This study aimed to determine the seroprevalence of T. gondii and its predictors among pregnant women seeking prenatal and medical care at the general maternal and child health facility in Dhamar district of Dhamar governorate, Yemen.MethodsA total of 420 pregnant women were randomly selected for this cross-sectional study. Participants were screened for anti-T. gondii antibodies (i.e. immunoglobulin M; IgM and immunoglobulin G; IgG) using electrochemiluminescence immunoassay. Demographic, socioeconomic, obstetric and behavioural data were collected using a pretested questionnaire via face-to-face interview. Univariate and multivariate analyses were used to identify the independent predictors of T. gondii seroprevalence.ResultsThe overall seroprevalence of anti-T. gondii antibodies (IgG and/or IgM) among the participants was 21.2% (89/420; 95% CI = 17.3–25.1). Anti-T. gondii IgG antibodies were detected in 20.0% (84/420) of the women of which 12.9% (54/420) were positive for only IgG and 7.1% (30/420) were positive for both IgG and IgM antibodies. Moreover, 5 women (1.2%) were reactive only for IgM antibodies. Significant associations between T. gondii seroprevalence and history of spontaneous abortion (P < 0.001), raw vegetables consumption (P = 0.036), and presence of cats in household (P = 0.049) were reported. Multivariate analysis confirmed that history of spontaneous abortion (AOR = 4.04; 95% CI = [2.46, 6.63]) and presence of cats in household (AOR = 1.77; 95% CI = [1.02, 3.07]) are significant predictors of T. gondii seroprevalence among the studied participants.ConclusionThe study found a high seroprevalence (21.2%) of T. gondii infection during pregnancy in Dhamar district, which is significantly associated with adverse pregnancy outcomes. The provision of adequate maternal healthcare and health education pertaining to the prevention of T. gondii infection is therefore imperative to curtail the prevalence of infection among the studied population.

show abstract

“…The detection of T. gondii infection in women was based on lateral flow chromatographic immunoassay for the simultaneous detection and differentiation o f I gM a nti-T. gondii and IgG anti-T.gondii using a commercial Combo rapid test cassette for whole blood, serum and plasma (BIOZEK medical,No.70). The positive result demonstrated by the appearance of two colored lines for control and test line region (Marques et al, 2015).…”

Section: Toxoplasmosis Detection In Womenmentioning

confidence: 98%

Detection of Toxoplasma Gondii in Cats and Seroprevalence in Women

Khayat

2022

ijvsbt

View full text Add to dashboard Cite

This study aimed to investigate the potential threat of domestic and stray cats to public health in transmitting the toxoplasmosis. One hundred and sixty samples (40 blood samples from owner, 40 blood samples from non owner women, 40 fecal samples from their cats, and 40 fecal samples from stray cats) were analyzed. All blood samples were subjected to IgM, IgG rapid test for toxoplasmosis detection, while the fecal samples from cat were subjected to microscopic examination for the presence of the oocyst using direct wet mount as well as flotation method. The results revealed the total infection rate in women was 23.75% (19/80) with significant differences between cats owner (30.00%) and non- cats owner (17.50%). The IgG antibody was detected in 68.42% (13/19) amounting 8/19 (42.10%) in cats owner and 5/19 (26.31%) in non-cats owner, and the presence of both IgG and IgM antibodies was recorded in 6/19 (31.57%) of the infected women (21.05% and 10.52% for cats owner and non-cats owner, respectively). The total infection rate for cats was 16.25% (13/80), with highly significant differences p<0.001 between domestic cats (10.00%) and stray cats (22.50%).

show abstract

Systematic review of serological methods used in prenatal screening of toxoplasmosis in pregnant women

Cited by 5 publications

References 42 publications

Toxoplasmosis in pregnancy: a clinical, diagnostic, and epidemiological study in a referral hospital in Rio de Janeiro, Brazil

Toxoplasmosis in pregnancy: a clinical, diagnostic, and epidemiological study in a referral hospital in Rio de Janeiro, Brazil

Prevalence and predictors of Toxoplasma gondii infection in pregnant women from Dhamar, Yemen

Detection of Toxoplasma Gondii in Cats and Seroprevalence in Women

Contact Info

Product

Resources

About