Systematic review on gastric electrical stimulation in obesity treatment

Maisiyiti, Alimujiang; Chen, Jiande Dz

doi:10.1080/17434440.2019.1673728

Cited by 15 publications

(27 citation statements)

References 49 publications

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“…When this frequency is the same as (or slightly higher than) the frequency of the intrinsic gastric slow waves, they enhance antral contractions and speed up gastric emptying 40–42 . However, when this frequency is higher than the frequency of the intrinsic gastric slow waves, they inhibit gastric motility such as gastric tone, contractions, and/or emptying 16 . In this study, we have chosen to use inhibitory GES, which corresponds to the second type of stimulation described above, where higher stimulation frequency implies inhibition of gastric motility.…”

Section: Discussionmentioning

confidence: 99%

“…When the maximum pulse width (8 ms) was reached, the amplitude was increased. The pulse width was increased first since it has been shown to be a key parameter that impacts gastric motility and reduces food intake compared to pulse amplitude 16,18–20,29,38 …”

Section: Methodsmentioning

confidence: 99%

“…As an alternative approach to treating obesity, gastric electrical stimulation (GES) has been investigated in the last few decades with promising pre‐clinical results. If long‐term clinical trials demonstrate efficacy in inducing and sustaining weight loss, GES would have the advantage of offering a minimally invasive, long‐term, reversible, and adjustable alternative to bariatric surgery 12,16,17 …”

Section: Introductionmentioning

confidence: 99%

“…Various types of GES techniques have been studied over the past few decades in animals and humans 12,16 . Recently, inhibitory GES, that impairs gastric motility using trains of pulses with a width longer than 1 ms, has been considered the most promising method for inducing weight loss 16,18–20 .…”

Section: Introductionmentioning

confidence: 99%

“…Adapting the stimulation energy for each individual also appears to be a prerequisite for optimization of GES therapy 12,16,19,20,27 . In addition, for mid‐to‐long‐term therapy efficacy, habituation to GES (i.e., decrease in the response to stimulation over time) must be considered, as reported in dogs 19 and assumed in humans 27 .…”

Section: Introductionmentioning

confidence: 99%

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Impact of adaptive gastric electrical stimulation on weight, food intake, and food intake rate in dogs

et al. 2021

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Background: Gastric electrical stimulation (GES) has been studied for decades as a promising treatment for obesity. Stimulation pulses with fixed amplitude and pulse width are usually applied, but these have limitations with regard to overcoming habituation to GES and inter-subject variation. This study aims to analyze the efficacy of an adaptive GES protocol for reducing food intake and maintaining lean weight in dogs.Methods: Six beagle dogs were implanted with a remotely programmable gastric stimulator. An adaptive protocol was designed to increase the stimulation energy proportionally to the excess of food consumption, with respect to the dogs' maintenance energy requirements. After surgery and habituation to experimental conditions, the dogs went through both a control and a stimulation period of 4 weeks each, in a randomized order. The stimulation parameters were adapted daily.Body weight, food intake, food intake rate, and postprandial cutaneous electrogastrograms (EGG) were recorded to assess the effect of adaptive GES. Results: Adaptive GES decreased food intake and food intake rate (p < 0.05) resulting in weight maintenance. In the absence of GES, the dogs gained weight (p < 0.05). Postprandial EGG dominant frequency was accelerated by GES (p < 0.05). The strategy of adapting the stimulation energy was effective in causing significant mid-term changes. Conclusion:Adaptive GES is effective for reducing food intake and maintaining lean weight. The proposed adaptive strategy may offer benefits to counter habituation and adapt to inter-subject variation in clinical use of GES for obesity.

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Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%