Systematic screening for occupations and occupational exposures in head and neck squamous cell carcinoma patients

Deneuve, Sophie; Charbotel, Barbara; Massardier-Pilonchéry, Amélie; Fort, Emmanuel; Milliet-Baude, Charlotte; Pérol, Olivia; Fayette, Jérôme; Zrounba, Philippe; Fervers, Béatrice

doi:10.1007/s00405-018-05275-7

Cited by 4 publications

(5 citation statements)

References 29 publications

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“…In a previous prospective and systematic assessment of occupational exposures in 154 head and neck SCC cancer patients managed at the Léon Bérard Cancer Center, solvent exposure was observed in 10 out of 67 patients (14.9%) with OCSCC, including three non-smoking patients (14). Several studies have investigated the association between oral cavity cancers and exposure to solvents, yet frequently grouped together with pharyngeal cancers (37).…”

Section: Discussionmentioning

confidence: 99%

“…In December 2021, the patient was referred to the occupational cancer consultation of the CLB ( 14 ) to review the job history and workplace exposures. The patient had been working during 18 years, from the ages 18 years to 36 years (1981–1999), as a screen printer in two successive printing enterprises employing two and 150 workers, respectively.…”

Section: Detailed Case Descriptionmentioning

confidence: 99%

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Gingiva squamous-cell carcinoma in a non-smoking patient with occupational exposure to solvent siphoning using mouth: case report and literature review

Lamouroux,

Brochet,

Zrounba

et al. 2024

Front. Public Health

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BackgroundWhile overall head and neck cancer incidence decreases due to reduced tobacco and alcohol consumption, the incidence of HPV negative oral cavity squamous cell carcinoma (SCC) is raising in several industrialized countries, especially in non-smoking and non-drinking patients.Case presentationWe document a case of gingiva SCC in a 56 years old never-smoker patient reporting low alcohol consumption and unusual occupational solvent exposure. The HPV-negative lesion was surgically removed in 2018, and the patient remains in complete remission 4 years after recurrent surgery in 2019. In 2021, the patient was referred to the occupational cancer consultation. The patient worked as screen printer for 18 years. He reported mouth siphoning every 2–3 days to transfer organic solvents (mainly aromatic hydrocarbons and ketones) from containers into smaller recipients, with regular passage of solvents into his mouth.ConclusionAccording to the literature, the frequency of solvent siphoning using mouth is likely to be underestimated. While our review did not find studies reporting longterm consequences to the oral cavity of mouth siphoning, current evidence supports a positive association of upper aero digestive tract SCC with occupational exposures to organic solvents and printing processes. In absence of major extraprofessional factors, the HPV-negative gingiva SCC of this patient might be attributable to the regular occupational oral solvent exposure. While the available evidence remains limited to formally establish a causal relationship, clinicians should investigate this hazardous work practice in patients with OSCC and history of solvent exposures.

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Section: Discussionmentioning

confidence: 99%

Section: Detailed Case Descriptionmentioning

confidence: 99%

Gingiva squamous-cell carcinoma in a non-smoking patient with occupational exposure to solvent siphoning using mouth: case report and literature review

Lamouroux,

Brochet,

Zrounba

et al. 2024

Front. Public Health

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“…In order to pursue the evaluation of the screening procedure in other medical situations, our process was also tested for other cancer sites (head and neck squamous cell carcinoma (HNSCC) and lymphoma) [ 41 ].…”

Section: Discussionmentioning

confidence: 99%

A Multicenter Study to Assess a Systematic Screening of Occupational Exposures in Lung Cancer Patients

Pérol

Lepage

Noelle

et al. 2023

IJERPH

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Occupational lung cancer cases remain largely under-reported and under-compensated worldwide. In order to improve the detection and compensation of work-related lung cancers, we implemented a systematic screening of occupational exposures, combining a validated self-administered questionnaire to assess occupational exposures and a specialized occupational cancer consultation. After a pilot study, the present prospective, open-label, scale-up study aimed to assess this systematic screening of occupational exposures in lung cancer patients in five sites in France by associating university hospitals with cancer centers. Patients with lung cancer were sent a self-administered questionnaire to collect their job history and potential exposure to lung carcinogens. The questionnaire was assessed by a physician to determine if a specialized occupational cancer consultation was required. During the consultation, a physician assessed if the lung cancer was occupation-related and, if it was, delivered a medical certificate to claim for compensation. Patients were offered help from a social worker for the administrative procedure. Over 15 months, 1251 patients received the questionnaire and 462 returned it (37%). Among them, 176 patients (38.1%) were convened to the occupational cancer consultation and 150 patients attended the consultation. An exposure to occupational lung carcinogen was identified in 133 patients and a claim for compensation was judged possible for 90 patients. A medical certificate was delivered to 88 patients and 38 patients received compensation. Our national study demonstrated that a systematic screening of occupational exposures is feasible and will bring a significant contribution to improve the detection of occupational exposures in lung cancer patients.

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“…Finally, the caveats of our study include the lack of matched controls and the retrospective study design, implying the use of TNM 7th edition, and the lack of more detailed information on previous leukoplakia as it is likely that informations about leukoplakia obtained from the patient's records were incomplete. Moreover, the retrospective design of this study did not allow to collect information on other factors of interest that have been suggested as a possible aetiology for HNSCC such as second-hand smoke [50], socio-economic status [51], environmental and occupational exposures [52], dietary habits [53], or chronic dental trauma [54]. Despite those limitations, our study is one of the largest multicentric studies in young adults with OTSCC below 40 years of age, with an important follow-up time, and few missing data.…”

Section: Discussionmentioning

confidence: 99%

Oral tongue squamous cell carcinomas in young patients according to their smoking status: a GETTEC study

Deneuve

Guerlain

Dupret‐Bories³

et al. 2021

Eur Arch Otorhinolaryngol

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Background Incidence of oral tongue squamous cell carcinoma (OTSCC) is increasing, especially in young adults, despite decreasing tobacco and alcohol consumption. Methods This multicentric retrospective study of 185 young adults with OTSCC (median follow-up 43 months), investigated risk factors, tumour characteristics and oncological outcomes according to the smoking status. Results Overall, 38% of patients were smokers (S). Non-smokers (NS) were significantly younger than S. Sex ratios were 1.1 for N and 1.8 for S. NS patients were less frequently cannabis or alcohol users than S, but were more likely to have a history of leukoplakia. Second primaries were observed in NS (4.4%) and in S (12.7%). Despite more frequent local relapse in NS (p = 0.018), there was no difference in diagnostic stage and overall survival between groups. Conclusion OTSCC affects differently young S and NS patients suggesting the existence of a specific clinical entity of OTSCC in non-smoking young adults.

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Systematic screening for occupations and occupational exposures in head and neck squamous cell carcinoma patients

Cited by 4 publications

References 29 publications

Gingiva squamous-cell carcinoma in a non-smoking patient with occupational exposure to solvent siphoning using mouth: case report and literature review

Gingiva squamous-cell carcinoma in a non-smoking patient with occupational exposure to solvent siphoning using mouth: case report and literature review

A Multicenter Study to Assess a Systematic Screening of Occupational Exposures in Lung Cancer Patients

Oral tongue squamous cell carcinomas in young patients according to their smoking status: a GETTEC study

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