Systemic allergic reaction by a human insulin analog

Barranco, Ruth; Herrero, T.; Tornero, Pilar; Barrio, M. De; Frutos, C. De; Rodríguez, A; Malvetti, V; Baeza, M.L.

doi:10.1034/j.1398-9995.2003.00143.x

Cited by 17 publications

(15 citation statements)

References 4 publications

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“…2,6,7 The present case corroborates the allergenic potential of short-acting and long-acting insulin analogues. The associated hypersensitivity to beta-lactam antibiotics is also noteworthy and has been previously reported in few cases of type 1 IgE-mediated insulin allergy.…”

Section: Discussionsupporting

confidence: 80%

Type 1 Ig-E mediated allergy to human insulin, insulin analogues and beta-lactam antibiotics

Andrade

Barros

Gonçalo

2012

An. Bras. Dermatol.

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Insulin, a crucial therapeutic agent for diabetes mellitus, has been rarely associated with hypersensitivity events. We present a 69-year-old type-2 diabetic patient with urticariform lesions on the sites of subcutaneous injection of insulin. The patient denied any known allergies, except for an unspecific cutaneous reaction after intramuscular penicillin administration in childhood. Prick tests revealed positive reactions to all tested human insulins and insulin analogues. Serum IgE levels were above normal range and RAST tests were positive for human, bovine and porcine insulins, as well as beta-lactams. Type 1 IgE-mediated allergy to insulin analogues demands a prompt diagnosis and represents a significant therapeutic challenge in diabetic patients.

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Section: Discussionsupporting

confidence: 80%

Type 1 Ig-E mediated allergy to human insulin, insulin analogues and beta-lactam antibiotics

Andrade

Barros

Gonçalo

2012

An. Bras. Dermatol.

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“…However, several case reports regarding development of local and generalized insulin allergy on insulin analogue treatment have been published [24,27,[35][36][37]. On the other hand, it has been shown that persistent cutaneous insulin allergy resulted from high-molecular-weight insulin aggregates [38].…”

Section: The Use Of Insulin Analoguesmentioning

confidence: 97%

Allergic reactions to human insulin: a review of current knowledge and treatment options

Akıncı

Yener

Bayraktar

et al. 2009

Endocr

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“…Successful treatment of insulin allergy in a 1-yearold infant with neonatal diabetes by lispro and glargine insulin was reported recently [52]. However, insulin allergy has also been reported with insulin lispro [53][54][55] and with insulin aspart [19,56]. One case of insulin allergy to insulin aspart, associated with insulin resistance, occurred in a patient with lung cancer and was considered as a paraneoplastic syndrome based on interleukin-6 secretion [56].…”

Section: Insulin Analogues and Insulin Allergymentioning

confidence: 99%

Allergy reactions to insulin: effects of continuous subcutaneous insulin infusion and insulin analogues

Radermecker

Scheen

2007

Diabetes Metabolism Res

113

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SUMMARYThe purification of animal insulin preparations and the use of human recombinant insulin have markedly reduced the incidence but not completely suppressed the occurrence of insulin allergy manifestations. Advances in technologies concerning the mode of delivery of insulin, i.e. continuous subcutaneous insulin infusion (CSII), and the use of insulin analogues, resulting from the alteration in the amino acid sequence of the native insulin molecule, may influence the immunogenicity and antigenicity of native insulin. Instead of increasing allergy reactions, CSII has been reported to represent a successful alternative treatment in diabetic patients presenting local or generalized allergy to insulin or other components (zinc, protamine) of conventional treatment. Most recent reports concern CSII-treated patients using short-acting insulin analogues (essentially insulin lispro), although the precise role of these insulin analogues remains unclear as allergy to 1 them has also been described. Finally, data on antigenicity and immunogenicity of long-acting insulin analogues (glargine, detemir), which may mimic the basal insulin delivery with CSII, remain scarce at present time.

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Systemic allergic reaction by a human insulin analog

Cited by 17 publications

References 4 publications

Type 1 Ig-E mediated allergy to human insulin, insulin analogues and beta-lactam antibiotics

Type 1 Ig-E mediated allergy to human insulin, insulin analogues and beta-lactam antibiotics

Allergic reactions to human insulin: a review of current knowledge and treatment options

Allergy reactions to insulin: effects of continuous subcutaneous insulin infusion and insulin analogues

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