Systemic and local anti-Mullerian hormone reflects differences in the reproduction potential of Zebu and European type cattle

Carter, Anja Stojsin; Mahboubi, Kiana; Costa, N. N.; Gillis, Daniel; Carter, Timothy F.; Neal, Michael S.; Miranda, M. S.; Ohashi, Otávio Mitio; Favetta, Laura A.; King, W. A.

doi:10.1016/j.anireprosci.2016.02.003

Cited by 16 publications

(9 citation statements)

References 27 publications

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“…On the other hand, a positive correlation between intrafollicular AMH, AFC and AMH receptor (AMHR2) was also found. Coincidentally, previous studies showed that cows with high AFC had increased mRNA expression of AMHR2α compared with low AFC cows (Stojsin‐Carter et al., 2016; Rosa et al., 2018) and the expression of AMHR2 has been negatively correlated with follicular growth and oocyte maturation (Fang et al., 2016; Pierre et al., 2016). Therefore, findings from the current study and a growing body of literature suggest that cattle with lower circulating AMH could present greater LH concentrations, higher amounts of LH receptors and low AMHR2 expression, consequently affecting the growth pattern of dominant follicles.…”

Section: Discussionmentioning

confidence: 98%

Anti‐Mullerian hormone and its relationship to ovulation response and fertility in timed AI Bos indicus heifers

Batista¹,

Vieira²,

Freitas³

et al. 2020

Reprod Domestic Animals

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This study evaluated the association between plasma anti‐Mullerian hormone (AMH) concentration and fertility in Nelore (Bos indicus) heifers submitted to timed artificial insemination (TAI). At the onset of the synchronization protocol, heifers (n = 289) received a subcutaneous P4 ear implant (3 mg) and 2 mg of oestradiol benzoate. Eight days later, the P4 implant was removed and 0.5 mg of oestradiol cypionate, prostaglandin (0.265 mg, i.m.) and equine chorionic gonadotropin (300 UI, i.m.) was administered, and TAI was performed 48 hr after ear implant removal. Ovarian ultrasound evaluations were performed to measure number of ovarian follicles, dominant follicle size and ovulation response. Pregnancy diagnosis was performed by ultrasound 30 days after AI. Heifers with greater circulating AMH had more antral follicles, a smaller dominant follicle near timed ovulation and lower ovulation response to the timed AI protocol compared to heifers with lower circulating AMH. Although AMH and pregnancy outcome had a quadratic‐shaped pattern, AMH was not significantly associated with fertility. In conclusion, heifers with lower AMH had larger follicles towards the end of the synchronization protocol and greater ovulation responses, whereas greater circulating AMH was unrelated to conception success.

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Section: Discussionmentioning

confidence: 98%

Anti‐Mullerian hormone and its relationship to ovulation response and fertility in timed AI Bos indicus heifers

Batista¹,

Vieira²,

Freitas³

et al. 2020

Reprod Domestic Animals

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“…showing that taurine cows with high AF had increased AMHR2a expression (Stojsin-Carter et al, 2016), but AMH expression was similar in cross-bred cows with low and high numbers of AF (Ireland et al, 2009 (Nguyen et al, 2012;Nimz, Spitschak, Schneider, Fürbass, & Vanselow, 2009;Nuttinck et al, 2008) and are considered important markers of follicular health and oocyte quality (Douville & Sirad, 2014;Nimz et al, 2009). Higher expression of CYP19A1 in cross-bred cows with low AF was reported in a previous study (Ireland et al, 2009).…”

Section: Discussionmentioning

confidence: 99%

“…The number of AF has also been used to select oocyte donor cows for in vitro embryo production in largescale programmes (Pontes et al, 2010(Pontes et al, , 2011. However, recent studies have observed contradictory results regarding the correlation between reproductive performance and number of AF, including fertilization (Nagai, Yanagawaa, Katagiria, & Naganoa, 2015) and conception rates (Santos et al, 2016), circulating levels of testosterone (Loureiro, Ereno, Favoreto, & Barros, 2016), and AMH expression in granulosa cells (Stojsin-Carter et al, 2016).…”

Section: Contentsmentioning

confidence: 99%

“…The number of AF was determined in 336 ovaries from 168 cows by the same previously trained team. All of the visible AF on the surface of both ovaries from each cow were counted (Cushmann et al, 2009;Fitzpatrick & Entwistle, 1997;Stojsin-Carter et al, 2016). The average number of AF (61.14) and standard deviation (SD 30.43) counted in the 168 pairs of ovaries were used to classify the animals into groups having low (≤31; average minus SD; n = 21) and high (≥92; average plus SD; n = 28) numbers of AF.…”

Section: Classification Of Animals According To the Number Of Antramentioning

confidence: 99%

“…Previous studies suggested that the number of antral follicles (AF) present in the ovary might affect the oocyte competence to support embryo development in cattle (Silva-Santos et al, 2014). The number of AF has also been described as a phenotypic marker of reproductive characteristics, such as the circulating levels of anti-Müllerian hormone (AMH; Stojsin-Carter et al, 2016), testosterone (Martinez, Sanderson, Quirke, Lawrence, & Juengel, 2016), oocyte quality (Ireland et al, 2009), response to superovulation treatments (Ireland et al, 2007), number and quality of embryos produced in vitro (Pontes et al, 2011;Santos et al, 2016), and pregnancy rates (Martinez et al, 2016;Mossa et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

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Molecular characteristics of granulosa and cumulus cells and oocyte competence in Nelore cows with low and high numbers of antral follicles

Rosa

Marinho

Rosa

et al. 2018

Reprod Domestic Animals

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The aims of this study were to investigate whether the number of antral follicles (AF) in the ovaries of Nelore cows is influenced with the developmental competence of oocytes to reach the blastocyst stage and to quantify the mRNA abundance of genes associated with folliculogenesis and oogenesis in granulosa and cumulus cells. A total of 168 cows were distributed into two experimental groups according to the number of AF, low (≤31) and high AF (≥92), which were determined based on the mean number of AF (61.14) ± SD (30.43). Granulosa and cumulus cells were used to assess the mRNA expression of 16 genes. Cumulus cells from cows with low AF had higher mRNA expression of genes involved in meiosis resumption (NPR-2, NPR-3) and cumulus cell expansion (FGF10), as well as a transcription factor involved in the regulation of oocyte maturation and cell proliferation (STAT3). Conversely, granulosa cells from females with high AF had higher expression of PGR and AMHR2a, which are involved in meiosis resumption and cumulus cell expansion. Cumulus-oocyte complexes (COCs) were collected from 356 cows with low and high AF populations to evaluate embryo development. Cleavage and blastocyst rates did not differ between the groups. In conclusion, our findings revealed that genes involved in folliculogenesis and oogenesis are differently expressed in cumulus and granulosa cells of cows having low and high numbers of AF. These molecular differences suggest that the regulation of oocyte maturation, meiotic resumption and cumulus expansion may be influenced by the number of AFs. However, the variations in gene expression were not associated with in vitro oocyte developmental competence to reach the blastocyst stage, which confirms that oocytes from Nelore cows with low and high numbers of AF are similarly able to mature, regulate the fertilization process and support pre-implantation embryo development.

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Lipid profile of in vitro embryos produced from Bos indicus cows with low and high antral follicle counts

et al. 2021

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Systemic and local anti-Mullerian hormone reflects differences in the reproduction potential of Zebu and European type cattle

Cited by 16 publications

References 27 publications

Anti‐Mullerian hormone and its relationship to ovulation response and fertility in timed AI Bos indicus heifers

Anti‐Mullerian hormone and its relationship to ovulation response and fertility in timed AI Bos indicus heifers

Molecular characteristics of granulosa and cumulus cells and oocyte competence in Nelore cows with low and high numbers of antral follicles

Lipid profile of in vitro embryos produced from Bos indicus cows with low and high antral follicle counts

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