Systemic and Local Cytokine Production in Quiescent Ulcerative Colitis and Its Relationship to Future Relapse: A Prospective Pilot Study

Abstract

Rectal mucosal IL-8 measurement might be an additional objective diagnostic tool that can predict relapse in patients with quiescent UC.

Elevated urinary cytokine levels in patients undergoing ileal neobladder replacement compared with sigmoid neobladder replacement

“…The production of inflammatory cytokines is markedly activated by bacterial attachment, and epithelial cells are one major source of these cytokines; therefore, this difference in the pattern of cytokine elevation according to the intestinal segment used for neobladder creation may reflect specific interaction between microbial ligands and host receptor in each organ [23]. Furthermore, the present findings are similar to those observed in inflammatory bowel disease [24][25][26][27]; that is, increased expressions of IL-6 and IL-8 were detected in mucosal biopsy specimens from patients with Crohn's disease and ulcerative colitis, respectively. These findings indicate the distinct participation of each cytokine in the pathogenesis of chronic asymptomatic bacteriuria in ileal and sigmoid neobladders.…”

Impacts of long-term enteral nutrition on clinical and endoscopic disease activities and mucosal cytokines during remission in patients with Crohnʼs disease: A prospective study

“…Our previous investigation [33][34][35] indicated that a cytokine assay can detect an ongoing escalating inflammation in the mucosa of patients with CD and ulcerative colitis, and that a cytokine assay could be an objective method to assess the degree of background mucosal inflammation. In line with this thinking, in this study ileocolonoscopy was regularly performed and multiple biopsies were obtained from both the terminal ileum and large bowel for cytokine assay.…”

Down-regulation of Protein and mRNA Expression of IL-8 and ICAM-1 in Colon Tissue of Ulcerative Colitis Patients by Partition-Herb Moxibustion

“…IL-8, an important inflammatory mediator, has an important role in the activation and recruitment of neutrophils to the inflamed tissues [10][11][12]. Many studies have reported that Partition-bran moxibustion 15 23 10 The differences between the two groups was significant (P \ 0.05), clinical therapeutic effect in partition-herb moxibustion is significantly better than those in partition-bran moxibustion the mucosal IL-8 productions were elevated in active UC patients, and large numbers of neutrophils were found in crypt abscesses [11,[13][14][15]. In UC, mucosal concentration of IL-8 in the inflamed site have been reported to correlate with disease severity [22][23][24][25].…”

“…IL-8, an important inflammatory mediator, has an important role in the activation and recruitment of neutrophils to the inflamed tissues [10][11][12]. Many studies have reported that the mucosal IL-8 productions were elevated in active UC patients, and large numbers of neutrophils were found in crypt abscesses [11,[13][14][15]. In addition, intercellular adhesion molecule-1 (ICAM-1) may play an important role in the occurrence and development of inflammation by inducing the rolling and adherence of neutrophilic granulocyte and monocyte on the endothelial cell [16,17].…”