Systemic and local effects of disportional longitudinal growth of bones in foals and lambs and the impact on bone mineral density and content

Liesegang, Annette; Giezendanner, R; Tanner, Stuart; Rechenberg, Brigitte von; Auer, Jörg A

doi:10.21836/pem20100402

Cited by 4 publications

(2 citation statements)

References 20 publications

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“…The time patterns of parameters related to BMD are in accordance with former results obtained in growing sheep in the studies of Liesegang et al. (, ) thus indicating a normal physiological process of ageing. Significant species differences in BMD between the two species were found in week 12 where lambs showed higher BMD levels compared to goat kids.…”

Section: Discussionsupporting

confidence: 90%

Influence ofUVBexposure on the vitamin D status and calcium homoeostasis of growing sheep and goats

Kovács

Wilkens

Liesegang

2015

Animal Physiology Nutrition

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SummaryThe purpose of this study was to investigate the influence of exposure to ultraviolet radiation (UVB) on vitamin D status, intestinal calcium absorption and bone metabolism in growing sheep and goats. The hypothesis was that growing sheep and goats are able to synthesise vitamin D within their skin as a result of UVB exposure and that respective consequences for their vitamin D blood levels and the associated parameters can be shown. Fourteen 18-week-old lambs and goat kids were kept in an UVB-free environment and randomly assigned to two groups. One group was daily exposed to UVB (300 watt) for 12 weeks, and the other served as a control group. Except for the exposure to UVB, all animals were kept under the same conditions and fed according to their requirements. Before the start of the experiment and every second week, blood samples were taken. Also the left metatarsus of each animal was analysed by quantitative computer tomography to test for bone mineral status before the start, in week 7 and at the end of the experiment. After 12 weeks, the animals were slaughtered and samples were taken from skin, gastrointestinal tract and kidney for further analyses. In this study, exposure to UVB led to increased serum 1,25-dihydroxyvitamin D (1,25VitD) levels in goat kids, whereas in lambs, serum 25-hydroxyvitamin D (25VitD) levels were increased. In both species UVB-exposed animals showed lower 7-dehydrocholesterol (7DHC) values in skin than their respective control groups. These results indicate that growing goat kids and lambs are able to synthesise vitamin D in the skin when being exposed to UVB.

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Section: Discussionsupporting

confidence: 90%

Influence ofUVBexposure on the vitamin D status and calcium homoeostasis of growing sheep and goats

Kovács

Wilkens

Liesegang

2015

Animal Physiology Nutrition

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“…Increase in SCL reflects the increasing bone mass in growing individuals while decrease in AP and OC is founded in a lower activity of osteoblasts and therefore slower increase in bone mass over time. Increase in SCL and decrease in OC both increase the SCL:OC which is known in growing individuals (Liesegang et al., ).…”

Section: Discussionmentioning

confidence: 99%

Vitamin D metabolism in growing pigs: influence of UVB irradiation and dietary vitamin D supply on calcium homeostasis, its regulation and bone metabolism

Kolp

Wilkens

Pendl

et al. 2017

Animal Physiology Nutrition

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SummaryThe aim of this study was to prove whether pigs are able to synthesize vitamin D (vitD) in the skin and to investigate the influence of ultraviolet irradiation (UVB) on vitD status and calcium (Ca) homeostasis of growing pigs. Thirty-two 11-week-old pigs were kept without access to sunlight and divided into four groups receiving the following treatment in a 2 9 2 factorial design: (i) UVB irradiation or not and (ii) vitD in feed or not. Blood, urine and faeces were sampled every third week. In serum, vitD metabolites, Ca, phosphorus (P), magnesium (Mg) and bone markers were analysed. Digestibility of Ca, P and Mg as well as urinary excretion of these minerals was analysed. After 14 weeks, the animals were slaughtered, and samples of skin, intestines, kidneys and bones (metatarsus) were taken for further analyses: sterols of vitD synthesis in the skin, Ca flux rates in the intestines, expression of genes involved in Ca transport in the intestines and kidneys, bone mineral density (BMD) with the aid of peripheral quantitative computer tomography and bone mineral content by ashing the metatarsus. Irradiated animals showed higher levels of 7-dehydrocholesterol and tachysterol in the skin, higher levels of 25-hydroxycholecalciferol and 1,25-dihydroxycholecalciferol in the serum and higher Ca net flux rates were determined in Ussing chambers. In contrast, the expression of genes involved in Ca transport in the intestines and kidneys was not altered. Similarly, the digestibility of Ca and P as well as the urinary excretion was not affected. With respect to the metatarsus, no differences in mineral contents and BMD were found between groups. At the end of the study, some subclinical signs of beginning vitD 'insufficiency' were observed in the group without access to vitD (represented by higher expression of 1a-hydroxylase in the kidney and increased parathyroid hormone in serum).

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Embryology and Anatomy of the Neonatal Musculoskeletal System

Adam

2024

Equine Neonatal Medicine

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Systemic and local effects of disportional longitudinal growth of bones in foals and lambs and the impact on bone mineral density and content

Cited by 4 publications

References 20 publications

Influence ofUVBexposure on the vitamin D status and calcium homoeostasis of growing sheep and goats

Influence ofUVBexposure on the vitamin D status and calcium homoeostasis of growing sheep and goats

Vitamin D metabolism in growing pigs: influence of UVB irradiation and dietary vitamin D supply on calcium homeostasis, its regulation and bone metabolism

Embryology and Anatomy of the Neonatal Musculoskeletal System

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