Systemic and Regional Hemodynamic Effects of Atriopeptin II in Anesthetized Rats

Criscione, Leoluca; Burdet, Richard; Hänni, Henry; Kamber, B.; Truog, A. G.; Hofbauer, Karl G.

doi:10.1097/00005344-198702000-00002

Cited by 13 publications

(7 citation statements)

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“…In a few rat studies employing the basic protocol described above the total renal blood flow was measured directly by means of electromagnetic (Pollock & Banks, 1983;Pollock & Arendshorst, 1986;Criscione et al 1987) or Doppler (Lappe, Smits, Todt, Debets & Wendt, 1985;Sonnenburg, Muir, Criscione, Kraetz & Hofbauer, 1985) flow probes on the renal artery. The responses to ANP were highly variable: no change or decrease in blood flow with no change or increase in renal vascular resistance were usually reported.…”

Section: Discussionmentioning

confidence: 99%

Atrial peptide natriuresis in the rat without genuine rise in filtration rate or wash‐out of medullary electrolytes.

Bądzyńska

Sadowski

Dobrowolski

1990

The Journal of Physiology

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SUMMARY1. Effects of synthetic atrial natriuretic peptide (ANP) on renal excretion, total renal blood flow (RBF), glomerular filtration rate (GFR) and tissue electrical admittance (reciprocal impedance, an estimate of tissue electrolytes) were determined in pentobarbitone-anaesthetized rats. GFR was measured both as inulin clearance (Cin) and as a product of renal plasma flow (RPF) and inulin extraction ratio (Ein). 3. With medium and high dosage (2 and 6,g/(kg min), respectively), major and rapid increases in sodium excretion and urine flow were associated with an acute increase in Cin but not RPF x Ein 4. The RBF increase observed in all groups of rats was not dose-related and did not parallel the natriuresis. Electrolyte concentration in the medullary tissue showed a modest transient decrease in rats given medium and high ANP doses.5. We conclude that pronounced ANP natriuresis can develop in the absence of a measurable increase of GFR, estimated by a method not subject to urinary dead space error (RPF x Ein). The small transient decrease in medullary tissue electrolytes observed with higher peptide doses does not support solute wash-out as an important mechanism of increased sodium excretion.

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Section: Discussionmentioning

confidence: 99%

Atrial peptide natriuresis in the rat without genuine rise in filtration rate or wash‐out of medullary electrolytes.

Bądzyńska

Sadowski

Dobrowolski

1990

The Journal of Physiology

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“…bolus at 10 and 20 pg kg-' but hypotension was associated with an increase in arteriole diameter only in the presence of the highest dose. Criscione et al (1987) have…”

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 98%

“…Injection of ANP into dogs and rats results in hypotension, increases in cardiac output and decreases in calculated total peripheral resistance (Criscione et al, 1987;Gardiner et al, 1988;Shen et al, 1991;Lappe et al, 1986). These effects appear to be due to the vasodilator actions of ANP on peripheral resistance elements (Seymour et al, 1985;Criscione et al, 1987;Shen et al, 1991). On the other hand, infusion of ANP almost always results in hypotension, reduced cardiac output and an increase in total peripheral resistance (Lappe et al, 1986;Criscione et al, 1987;Zimmerman et al, 1987;Shen et al, 1991).…”

Section: Introductionmentioning

confidence: 99%

“…These effects appear to be due to the vasodilator actions of ANP on peripheral resistance elements (Seymour et al, 1985;Criscione et al, 1987;Shen et al, 1991). On the other hand, infusion of ANP almost always results in hypotension, reduced cardiac output and an increase in total peripheral resistance (Lappe et al, 1986;Criscione et al, 1987;Zimmerman et al, 1987;Shen et al, 1991).…”

Section: Introductionmentioning

confidence: 99%

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Effect of endopeptidase‐24.11 inhibitors and C‐ANP receptor ligand on responses evoked in arterioles of rat cremaster muscle by atrial natriuretic peptide

Peyroux

Beslot

Claperon

et al. 1995

British J Pharmacology

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1 The present study examined the effect of exogenous atrial natriuretric peptide (ANP), alone or in presence of inhibitors of the two major mechanisms for clearing ANP, metabolism by neutral endopeptidase-24.11 (NEP) and internalization by C-ANP receptors, on arteriolar responses using intravital microscopy on the rat cremaster muscle after intravenous or topical administration of the peptide. 2 Topical application of ANP (3 x 10-10 to 3 x 10-8 M) produced a gradual increase in arteriolar diameter. NEP inhibitors, thiorphan (30 mg kg-', i.v.), kelatorphan (10 mg kg-', i.v.) and retrothiorphan (25 mg kg-', i.v.) alone, did not significantly affect vascular tone but caused significant potentiation of the arteriolar responses to topically applied ANP. 3 When given as an i.v. bolus, ANP dilates skeletal arterioles at a high dose (20 Mg kg-'). At a lower dose (10 ug kg'-), ANP alone or with retrothiorphan or the C-ANP receptor ligand C-ANP (4-23) did not produce any arteriolar responses, while after the combined administration of the two inhibitors, an increase in arteriolar diameter was induced. 4 These results indicate that low doses of topically applied ANP dilate rat cremaster arterioles and that the vasodilator responses can be potentiated by NEP inhibition. When given as an i.v. bolus, a high dose of ANP can also dilate skeletal arterioles. However at a lower dose the rapid metabolism of the peptide prevents it from producing its action.

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Comparative study of cardiac electrophysiological effects of atrial natriuretic peptide

Kecskeméti

Pacher

Pankucsi

et al. 1996

Biochemical Mechanisms in Heart Function

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Systemic and Regional Hemodynamic Effects of Atriopeptin II in Anesthetized Rats

Cited by 13 publications

References 0 publications

Atrial peptide natriuresis in the rat without genuine rise in filtration rate or wash‐out of medullary electrolytes.

Atrial peptide natriuresis in the rat without genuine rise in filtration rate or wash‐out of medullary electrolytes.

Effect of endopeptidase‐24.11 inhibitors and C‐ANP receptor ligand on responses evoked in arterioles of rat cremaster muscle by atrial natriuretic peptide

Comparative study of cardiac electrophysiological effects of atrial natriuretic peptide

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