Systemic and topical corticosteroid treatment of oral lichen planus: a comparative study with long‐term follow‐up

Carbone, M; Goss, Erin; Carrozzo, Marco; Castellano, Sandra; Conrotto, Davide; Broccoletti, Roberto; Gandolfo, S

doi:10.1034/j.1600-0714.2003.00173.x

Cited by 168 publications

(157 citation statements)

References 28 publications

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“…In our study, complete remission was observed in 66.7% (n=10) and partial remission in 33.4% (n=5) of patients after eight weeks of treatment with prednisolone 40 mg/day along with tapered doses, which was more or less similar to the results reported by Carbone M et al [24] A double blind placebo controlled randomized clinical trial conducted by Saawar N et al [6] transformation (up to 0.2-2%) as compared to another forms. [25,26] Therefore, it may be presumed that lycopene and prednisolone may decrease the risk of malignant transformation in OLP.…”

Section: Discussionsupporting

confidence: 81%

“…Carbone M et al [24] found 40.9% (n=9) of patient with complete remission and 50 % (n=11) patients with partial remission of OLP lesion in initial two months of treatment with prednisolone 50 mg/day along with tapered doses. In our study, complete remission was observed in 66.7% (n=10) and partial remission in 33.4% (n=5) of patients after eight weeks of treatment with prednisolone 40 mg/day along with tapered doses, which was more or less similar to the results reported by Carbone M et al [24] A double blind placebo controlled randomized clinical trial conducted by Saawar N et al [6] transformation (up to 0.2-2%) as compared to another forms.…”

Section: Discussionmentioning

confidence: 99%

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Comparative Study of the Efficacy of Lycopene Versus Prednisolone in the Management of Oral Lichen Planus- A Randomized, Double Blind Clinical Trial.

Kushwaha¹

2017

WJPPS

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Oral lichen planus (OLP) is a chronic inflammatory, immunologically mediated mucocutaneous disorder. Numerous topical and systemic therapies have been used in the treatment of OLP. Most of the current available treatments are palliative rather than curative. Corticosteroids are considered as the main treatment drugs. Unfortunately, some patients may develop refractory or resistance to corticosteroids therapy. This study aims to evaluate and compare the efficacy of lycopene and prednisolone in the management of OLP. This was a double-blind randomized comparative study in which clinically and histopathologically proven symptomatic OLP patients were enrolled and divided into two groups. Lycopene group received oral lycopene 4 mg/day (n=13) and prednisolone group received oral prednisolone 40 mg/day (n=15) for eight consecutive weeks. Assessments were made at baseline and after 2, 4, 6 and 8 weeks of treatment, based on the Numerical Rating Scale (NRS) and the Piboonniyom REU (Reticular, Erythematous and Ulceration) severity score. From the results obtained, the reduction of NRS burning sensation scores was statistically significant after two weeks of treatment in both groups. REU severity scores were decreased by 74% (p=0.005) and 91% (p=0.001) in lycopene and prednisolone groups respectively. Complete remission (EI=100%) of lesion was observed in two (15.4%) patients treated with lycopene and ten (66.7%) patients treated with prednisolone. However, the overall treatment response was

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Section: Discussionsupporting

confidence: 81%

Section: Discussionmentioning

confidence: 99%

Comparative Study of the Efficacy of Lycopene Versus Prednisolone in the Management of Oral Lichen Planus- A Randomized, Double Blind Clinical Trial.

Kushwaha¹

2017

WJPPS

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“…For instance, clobetasol propionate appeared to be one of the most effective topical steroids, as in an adhesive base led to complete remission in 56-75% of patients [17][18][19]. Unfortunately, some patients are refractory to topical corticosteroids.…”

Section: Discussionmentioning

confidence: 99%

Clinical evaluation of the efficiency of low-level laser therapy for oral lichen planus: a prospective case series

et al. 2013

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This is an author version of the contribution published on:Questa è la versione dell 'autore dell'opera: Lasers Med Sci. 2014 Jan;29(1):185-90. doi: 10.1007/s10103-013-1313 The definitive version is available at:La versione definitiva è disponibile alla URL: http://link.springer.com/article/10.1007URL: http://link.springer.com/article/10. /s10103-013-1313 Clinical evaluation of the efficiency of low-level laser therapy for oral lichen planus: a prospective case series. Eighty-two lesions were treated. We reported significant reduction in clinical scores of the treated lesions and in reported pain. No detailed complications or therapy side effects were observed during the study. AdrianaAs previously reported by our group with a preliminary report, this study suggests that LLLT could be a possible treatment choice for patients with unresponsive symptomatic OLP, also reducing the possible invasiveness correlated with other therapies.

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“…Sin embargo, no se han encontrado diferencias estadísticamente significativas, no debiéndose olvidar además los efectos secundarios que el tratamiento sistémico es capaz de provocar. El tratamiento sistémico debería reservarse para aquellos pacientes con un LPO recalcitrante, en forma erosiva o atrófica, en el que el tratamiento tó-pico no está haciendo efecto, o en el que la extensión sistémica del LPO complica su manejo tópico (45).…”

Section: Sistémicosunclassified

Liquen plano: Revisión de la literatura actual

Matesanz-Pérez¹,

Bascones-Martínez²

2009

Av Odontoestomatol

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RESUMENObjetivo: Proporcionar información actualizada acerca del liquen plano oral, prestando atención especial a su posible malignización y a su relación con el cáncer oral. El liquen es una enfermedad mucocutánea con una relevancia particular en la cavidad oral, no sólo debida a su prevalencia, sino también debida al hecho de estar englobada dentro de los denominados "enfermedades o estados premalignos". La relación del liquen plano con el cáncer oral aumenta la necesidad de revisar la literatura, para así comprender cuánto puede hacer el clínico al respecto, y aprender cómo manejar esta patología.Palabras clave: Liquen plano oral; apoptosis; cáncer oral; tratamiento; inmunología; linfocitos. SUMMARY Aims:To provide updated knowledge about oral lichen planus, paying especial attention to its possible malignant transformation and the relationship with oral cancer. Oral lichen planus is a mucocutaneous disorder with particular relevance in the oral cavity, not only due to its prevalence, but due to the fact of belonging to the group of "premalignant lesions or states". The relationship that this pathology has with oral cancer increases the need for literature reviewing so as to learn what the practitioner can do about it and how to manage it.Key words: Oral lichen planus; apoptosis; oral cancer; treatment; immunology; lymphocytes. Liquen plano: Revisión de la literatura actual Oral lichen planus. A review of literatureMatesanz-Pérez P*, Bascones-Martínez, A** INTRODUCCIÓNEl liquen plano oral es un desorden del epitelio escamoso que cobra importancia por dos motivos principalmente: por un lado está su frecuente aparición en todo el mundo, especialmente en sujetos de edad media, con mayor incidencia en el sexo femenino (1). Por otro lado, el liquen plano debe ser estudiado con cuidado dado su potencial de malignización. A pesar de la permanente controversia entre las distintas fuentes a la hora de establecer las probabilidades de que el liquen oral sufra una transformación ma-

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Systemic and topical corticosteroid treatment of oral lichen planus: a comparative study with long‐term follow‐up

Abstract: The most suitable corticosteroid therapy in the management of OLP is the topical therapy, which is easier and more cost-effective than the systemic therapy followed by topical therapy.

Cited by 168 publications

References 28 publications

Comparative Study of the Efficacy of Lycopene Versus Prednisolone in the Management of Oral Lichen Planus- A Randomized, Double Blind Clinical Trial.

Comparative Study of the Efficacy of Lycopene Versus Prednisolone in the Management of Oral Lichen Planus- A Randomized, Double Blind Clinical Trial.

Clinical evaluation of the efficiency of low-level laser therapy for oral lichen planus: a prospective case series

Liquen plano: Revisión de la literatura actual

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