Systemic antibiotics for chronic suppurative otitis media

Abstract

This is a protocol for a Cochrane Review (Intervention). The objectives are as follows:To assess the effects of systemic antibiotics for people with chronic suppurative otitis media (CSOM).

Tunable ciprofloxacin delivery through personalized electrospun patches for tympanic membrane perforations

“…Therefore, multiple treatment strategies have been clinically tested for inhibiting the polymicrobial growth responsible for this chronic infection. These include systemic or topical use of antibiotics, topical antiseptics, and ear cleaning, which are routinely applied alone or in combination with each other [ 13 , 14 , 71 , 72 ]. In this regard, broad-spectrum otic fluoroquinolones, such as CIP, which have been approved by the EMA and FDA, have emerged as the primary first-line therapy for managing CSOM-induced otorrhea.…”

“…1 A). In this regard, broad-spectrum antibiotics such as second-generation aminoglycosides and quinolones have been applied extensively in the clinics [ 13 , 14 ]. Among them, ciprofloxacin (CIP), an FDA-approved fluoroquinolone, has been found to be particularly effective in inhibiting the microorganism growth, while showing no ototoxicity toward the delicate inner ear [ 15 , 16 ].…”

Persistent Pseudomonas Infection Mastoiditis—Local Antibiotic Treatment Is Superior than Systemic

“…Study done by LY Chong et al 2021 shows that topical quinolones may be slightly more effective at resolving ear discharge at one to two weeks than oral quinolones (risk ratio (RR) 1.48, 95% confidence interval (CI) 1.24 to 1.76. [14] Most drops marketed specifically for otologic use contain Neomycin combined with a cationic detergent (Polymyxin B).…”

Otitis externa

“…Evidensen for peroral antibiotikabehandling for EO er svag [25], derfor skal der ved manglende respons på peroral behandling eller mistanke om komplikationer henvises til hospital og udredes som anført.…”