Systemic Antifungal Therapy

Moossavi, Meena; Bagheri, Bita; Scher, Richard K.

doi:10.1016/s0733-8635(05)70228-x

Cited by 21 publications

(11 citation statements)

References 181 publications

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“…A drug reaction is an unlikely cause of our patient's PL or ITP, given her limited medication profile and the absence of any documented associations of these medications with either of the diseases. Neither griseofulvin nor hydroxyzine has been associated with thrombocytopenia or PL‐like rash (11,12). There is no evidence to suggest that our patient's clinical presentation is consistent with a drug reaction.…”

Section: Discussionmentioning

confidence: 99%

Pityriasis Lichenoides and Idiopathic Thrombocytopenic Purpura in a Young Girl

García

Connelly²,

Newbury

et al. 2006

Pediatric Dermatology

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Pityriasis lichenoides is an inflammatory skin disorder characterized by erythematous, desquamative papules and plaques. An acute form, pityriasis lichenoides et varioliformis acuta, and a chronic form, pityriasis lichenoides chronica, represent the two ends of the spectrum of this disorder. Most commonly seen in children and young adults, its etiology is unknown. We describe a young patient with concurrent pityriasis lichenoides and idiopathic thrombocytopenia purpura, a previously unreported association.

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Section: Discussionmentioning

confidence: 99%

Pityriasis Lichenoides and Idiopathic Thrombocytopenic Purpura in a Young Girl

García

Connelly²,

Newbury

et al. 2006

Pediatric Dermatology

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“…Spirocycles are well represented among natural products, molecules which have evolved largely to interact with proteins. The spirocyclic natural product griseofulvin has in fact been used clinically [3]. For structure-based drug design (SBDD), it is important to note that spirocycles composed of six-membered or smaller rings are either rigid or have a limited number of well-defined conformations.…”

Section: Introductionmentioning

confidence: 99%

The utilization of spirocyclic scaffolds in novel drug discovery

Zheng¹,

Tice²

2016

Expert Opinion on Drug Discovery

221

143

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“…Griseofulvin concentrates in the stratum corneum of the skin and causes mitotic arrest during microtubule spindle formation in actively growing fungi [41]. Cure is difficult to achieve and the recurrence rate is high.…”

Section: Treatmentmentioning

confidence: 99%

Dermatology for the practicing allergist: Tinea pedis and its complications

et al. 2004

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Tinea pedis is a chronic fungal infection of the feet, very often observed in patients who are immuno-suppressed or have diabetes mellitus. The practicing allergist may be called upon to treat this disease for various reasons. Sometimes tinea infection may be mistaken for atopic dermatitis or allergic eczema. In other patients, tinea pedis may complicate allergy and asthma and may contribute to refractory atopic disease. Patients with recurrent cellulitis may be referred to the allergist/immunologist for an immune evaluation and discovered to have tinea pedis as a predisposing factor. From a molecular standpoint, superficial fungal infections may induce a type2 T helper cell response (Th2) that can aggravate atopy. Th2 cytokines may induce eosinophil recruitment and immunoglobulin E (IgE) class switching by B cells, thereby leading to exacerbation of atopic conditions. Three groups of fungal pathogens, referred to as dermatophytes, have been shown to cause tinea pedis: Trychophyton sp, Epidermophyton sp, and Microsporum sp. The disease manifests as a pruritic, erythematous, scaly eruption on the foot and depending on its location, three variants have been described: interdigital type, moccasin type, and vesiculobullous type. Tinea pedis may be associated with recurrent cellulitis, as the fungal pathogens provide a portal for bacterial invasion of subcutaneous tissues. In some cases of refractory asthma, treatment of the associated tinea pedis infection may induce remission in airway disease. Very often, protracted topical and/or oral antifungal agents are required to treat this often frustrating and morbid disease. An evaluation for underlying immuno-suppression or diabetes may be indicated in patients with refractory disease.

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Systemic Antifungal Therapy

Cited by 21 publications

References 181 publications

Pityriasis Lichenoides and Idiopathic Thrombocytopenic Purpura in a Young Girl

Pityriasis Lichenoides and Idiopathic Thrombocytopenic Purpura in a Young Girl

The utilization of spirocyclic scaffolds in novel drug discovery

Dermatology for the practicing allergist: Tinea pedis and its complications

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