Systemic Atherosclerosis Causes Detrusor Overactivity: Functional and Morphological Changes in Hyperlipoproteinemic apoE
            <sup>–/–</sup>
            LDLR
            <sup>–/–</sup>
            Mice

Bschleipfer, Thomas; Dannenmaier, A; Illig, Christian; Kreisel, Melanie; Gattenlöhner, Stefan; Langheinrich, Alexander C.; Krombach, Gabriele A.; Weidner, W.; Kampschulte, Marian

doi:10.1016/j.juro.2014.08.098

Cited by 17 publications

(15 citation statements)

References 27 publications

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“…This model did not exhibit alterations of bladder contraction responses in vitro (Shenfeld et al 2005), but upon concomitant knock-out of the genes for apolipoprotein E and the low density lipoprotein receptor, detrusor overactivity was observed (Bschleipfer et al 2015).…”

Section: Effects Of Chronic Hypoperfusion Of the Bladdermentioning

confidence: 83%

Are blood vessels a target to treat lower urinary tract dysfunction?

Michel

Chess-Williams

Hegde

2015

Naunyn-Schmiedeberg's Arch Pharmacol

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Bladder dysfunction is common in the general population (Stewart et al. 2010) and even more so among patients seeing a physician for any reason (Goepel et al. 2002). It often manifests as lower urinary tract symptoms (LUTS), a term originally coined to describe voiding and storage symptoms in men with benign prostatic hyperplasia (BPH) but now more universally used to describe any type of voiding and storage symptoms in both sexes. Studies into possible causes of urinary bladder dysfunction have long focused on detrusor smooth muscle cells (Turner and Brading 1999). More recently, it became clear that several other types of cells and organs contribute to regulating detrusor smooth muscle function. These include the urothelium (Andersson and McCloskey 2014; Michel 2015), afferent nerves (Michel and Igawa 2015; Yoshimura et al. 2014b), and the central and autonomic nervous systems (Fowler and Griffiths 2010; Yoshimura et al. 2014a). Alterations in any of these may at least partly be responsible for detrusor dysfunction and, accordingly, be potential targets for the treatment of bladder dysfunction. As highlighted by an article in this issue of Naunyn-Schmiedeberg's Archives of Pharmacology (Bayrak et al. 2015), there is an additional suspect, the bladder vasculature. This article will discuss the currently available experimental and clinical evidence for a role of the vasculature in causing bladder dysfunction, and how existing and emerging treatments may modulate bladder function by acting on blood vessels. Due to a similarity in concept, data on prostate perfusion will also be discussed to some extent.

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Section: Effects Of Chronic Hypoperfusion Of the Bladdermentioning

confidence: 83%

Are blood vessels a target to treat lower urinary tract dysfunction?

Michel

Chess-Williams

Hegde

2015

Naunyn-Schmiedeberg's Arch Pharmacol

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“…Endothelial injury of the iliac arteries and a high cholesterol diet has been shown to induce atherosclerosis and arterial occlusive disease in rats, leading to chronic bladder ischemia and DO . A systemic atherosclerosis mouse model has shown a significantly greater prevalence of DO in the atherosclerotic mice compared to controls …”

Section: Introductionmentioning

confidence: 99%

Vascular measures of atherosclerosis in detrusor overactivity and controls

Ladanchuk

Kwak

Bates

et al. 2018

Neurourology and Urodynamics

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“…To avoid neurogenic-dependent bladder dysfunction, all mice with neurological impairment were discarded. Compared with age-matched wild type mice, the 60-week-old double apoE/LDLE knockout mice showed decreased micturition intervals, impaired bladder functional capacity, decreased bladder wall vascularisation and infiltration of all bladder layers by inflammatory cells [36] . As attractive as this model might be, one must be cautious in its interpretation.…”

Section: Animal Models Of Ischemia-induced Bladder Dysfunctionmentioning

confidence: 82%

“…Numerous animal models have been developed in order to investigate the association between ischemia and bladder dysfunction using mice, rats and rabbits [36][37][38][39][40][41][42][43][44][45][46][47][48] .…”

Section: Animal Models Of Ischemia-induced Bladder Dysfunctionmentioning

confidence: 99%

Lower Urinary Tract Symptoms and Aging: The Impact of Chronic Bladder Ischemia on Overactive Bladder Syndrome

Camões

Coelho²,

Castro-Díaz

et al. 2015

Urol Int

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Introduction: The overactive bladder syndrome (OAB) is one of the most common and bothersome subsets of lower urinary tract symptoms (LUTS), affecting predominantly the aged population, with a worldwide distribution. This syndrome has not been completely understood, yet the aging process and the decreased blood flow to the bladder have been highlighted as closely related to this phenomenon. Materials and Methods: We performed a search on the online database PubMed/MEDLINE with the following MESH terms: ‘Overactive Bladder AND (Ischemia OR Aging OR Vascular Disease)'. We considered manuscripts written in English and published in the last 10 years (2004-2014, October). Additional manuscripts, such as referenced by reviews, were further included. Results: The aging process and the structural and functional changes resulting from an ischemic process emerge as important features that contribute to OAB. The ischemic-induced molecular and structural modifications that occur in the bladder have only recently been the objective of thorough studies, which link cardiovascular risk factors, vascular lesions and OAB. New animal models are being created to test new areas of treatment or prevention of ischemic-induced bladder dysfunction. Conclusion: Recent data point out that several physiological and pathological modifications that occur in the bladder associated with OAB and aging are closely related to ischemia.

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Systemic Atherosclerosis Causes Detrusor Overactivity: Functional and Morphological Changes in Hyperlipoproteinemic apoE ^–/– LDLR ^–/– Mice

Cited by 17 publications

References 27 publications

Are blood vessels a target to treat lower urinary tract dysfunction?

Are blood vessels a target to treat lower urinary tract dysfunction?

Vascular measures of atherosclerosis in detrusor overactivity and controls

Lower Urinary Tract Symptoms and Aging: The Impact of Chronic Bladder Ischemia on Overactive Bladder Syndrome

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Systemic Atherosclerosis Causes Detrusor Overactivity: Functional and Morphological Changes in Hyperlipoproteinemic apoE –/– LDLR –/– Mice

Cited by 17 publications

References 27 publications

Are blood vessels a target to treat lower urinary tract dysfunction?

Are blood vessels a target to treat lower urinary tract dysfunction?

Vascular measures of atherosclerosis in detrusor overactivity and controls

Lower Urinary Tract Symptoms and Aging: The Impact of Chronic Bladder Ischemia on Overactive Bladder Syndrome

Contact Info

Product

Resources

About

Systemic Atherosclerosis Causes Detrusor Overactivity: Functional and Morphological Changes in Hyperlipoproteinemic apoE ^–/– LDLR ^–/– Mice