Systemic betamethasone accelerates functional recovery after a crush injury to rat sciatic nerve

Al-Bishri, Awwad; Dahlin, Lars B.; Rosenquist, Jan; Sunzel, Bo

doi:10.1016/s0901-5027(05)80996-8

Cited by 8 publications

(11 citation statements)

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“…It inhibits lipid peroxidation and reduces the posttraumatic degenerative changes after neural injury 10 . However, the use of corticosteroids has been debateful in recent years 11,12 .…”

Section: Methylprednisolone (Mps) Is An Effective Neuroprotectivementioning

confidence: 99%

Effect of ozone and methylprednisolone treatment following crush type sciatic nerve injury

et al. 2016

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PURPOSE:To assess and compare the histopathological effects of ozone therapy and/or methylprednisolone (MPS) treatment on regeneration after crush type sciatic nerve injury. METHODS:Forty Sprague-Dawley male rats were randomly allocated into four groups. Four groups received the following regimens intraperitoneally every day for 14 days after formation of crush type injury on sciatic nerve: Group I: ozone (20mcg/ml); Group II: methylprednisolone (2mg/kg); Group III: ozone (20 mcg/ml) and methylprednisolone (2mg/kg); Group IV: isotonic saline (0.9%). The histomorphological evaluation was made after biopsies were obtained from the sites of injury.RESULTS: Significant differences were noted between groups in terms of degeneration (p=0.019), nerve sheath cell atrophy (p=0.012), intraneural inflammatory cellular infiltration (p=0.002), perineural granulation tissue formation (p=0.019), perineural vascular proliferation (p=0.004), perineural inflammatory cellular infiltration (p<0.001) and inflammation in peripheral tissue (p=0.006).Degeneration was remarkably low in Group III, while no change in nerve sheath cell was noted in Group II. CONCLUSION:The combined use of methylprednisolone and ozone treatment can have beneficial effects for regeneration after crush type nerve injury.

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“…It inhibits lipid peroxidation and reduces the posttraumatic degenerative changes after neural injury 10 . However, the use of corticosteroids has been debateful in recent years 11,12 .…”

Section: Methylprednisolone (Mps) Is An Effective Neuroprotectivementioning

confidence: 99%

Effect of ozone and methylprednisolone treatment following crush type sciatic nerve injury

et al. 2016

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“…For this purpose, many pharmacological agents are tried experimentally and successful results were reported [9][10][11][12][13][14]. However, these studies did not go beyond the experimental studies.…”

Section: Discussionmentioning

confidence: 99%

“…Although this process is often facilitated by a permissive environment in the periphery, some factors can impede normal return to function, such as the distance from injury site, metabolic disturbances, age and type of lesion [5][6][7][8]. Experimentally, a lot of medications were used in rat crush injury models such as steroids, nonsteroidal anti-inflammatory drugs and vitamins [9][10][11]. Some antioxidants such as Acetyl-L carnitine (ALCAR), FK506, polyethylene glycol (PEG) are used experimentally in treatment of nerve crush injuries [12][13][14].…”

Section: Introductionmentioning

confidence: 99%

Effect of Zofenopril on regeneration of sciatic nerve crush injury in a rat model

Kalender

Doğan

Bakan

et al. 2014

J Brachial Plex Peripher Nerve Inj

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BackgroundZofenopril is an antioxidant agent which has been shown to have beneficial effects in hypertension and heart failure. The aim of this study was to test the effects of Zofenopril on nerve regeneration and scarring in a rat model of peripheral nerve crush injury.MethodsTwenty-one adult Sprague-Dawley rats underwent a surgical procedure involving right sciatic nerve crush injury. 15 mg/kg Zofenopril was administered orally to seven rats in group Z for seven days. Seven rats in group S received saline orally for seven days. Seven rats in the control group C received no drug after crush injury. Fourteenth and 42nd days after injury, functional and electromyography assessments of nerves were performed. Functional recovery was analyzed using a walking track assessment, and quantified using the sciatic functional index (SFI). After these evaluations, all rats were sacrificed and microscopic evaluations were performed.ResultsThe Sciatic functional Index (SFI) in group Z on 14th day is different significantly from group S and group C (p = 0.037). But on 42nd day there was no difference between groups (p = 0.278). The statistical analyses of electromyelographic (EMG) studies showed that the latency in group Z is significantly different from group S (p = 0.006) and group C (p = 0.045). But on 42nd day there was no difference between groups like SFI (p = 0.147). The amplitude was evaluated better in group Z than others (p < 0.05). In microscopic evaluation, we observed the highest number of nerve regeneration in the group Z and the lowest in the group C. But it was not significant statistically.ConclusionOur results demonstrate that Zofenopril promotes the regeneration of peripheral nerve injuries in rat models.

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“…The mechanism of protection could be related to its ability to induce the synthesis of manganese superoxide dismutase (MnSOD), a mito chondrial enzyme involved in detoxifi cation of superoxide radicals. 24 On the other hand, Al-Bishri et al 50 also showed that the preoperative administration of the steroid bethamethasone improved the functional recovery of the rat sciatic nerve, as measured by the toe-spreading ability.…”

Section: Functional Recovery Enhancement Following Injury By Hericiummentioning

confidence: 99%

Functional Recovery Enhancement Following Injury to Rodent Peroneal Nerve by Lion's Mane Mushroom, Hericium erinaceus (Bull.: Fr.) Pers. (Aphyllophoromycetideae)

et al. 2009

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Peripheral nerve injury represents a huge burden to society. Following peripheral nerve injury, improved behavioral outcome may be the most important evidence of functionality of axonal regeneration after any repair strategy. Nerve-crush injury is a well-established axonotmetic model in experimental regeneration studies to investigate the impact of various pharmacological treatments. Hericium erinaceus is a temperate mushroom but is now being cultivated in tropical Malaysia. In this study, we investigated the activity of aqueous extract of H. erinaceus fresh fruitbodies in promoting functional recovery following an axonotmetic peroneal nerve injury in adult female Sprague-Dawley rats with a long-term view toward the possible use of this mushroom in the treatment of nerve injury. Functional recovery was assessed in the behavioral experiment by walking-track analysis and toespreading refl ex. The peroneal functional index (PFI) was determined before surgery and after surgery, as the rats showed signs of recovery. Analysis of the PFI indicated that the return of hind-limb function occurred by day 10 to 14 and by day 14 to 17 in the treated and control (nontreated) groups, respectively. Normal toe-spreading in the crushed limb was achieved by day 7 to 10 and day 12 to 17 in the treated and control group, respectively. These results suggest that daily administration of aqueous extract of H. erinaceus fresh fruitbodies has a benefi cial effect on the recovery of injured rat peroneal nerve in the early stages of regeneration. The PFI and toe-spreading refl ex improved faster in the treated group than in the nontreated group.

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Systemic betamethasone accelerates functional recovery after a crush injury to rat sciatic nerve

Cited by 8 publications

References 0 publications

Effect of ozone and methylprednisolone treatment following crush type sciatic nerve injury

Effect of ozone and methylprednisolone treatment following crush type sciatic nerve injury

Effect of Zofenopril on regeneration of sciatic nerve crush injury in a rat model

Functional Recovery Enhancement Following Injury to Rodent Peroneal Nerve by Lion's Mane Mushroom, Hericium erinaceus (Bull.: Fr.) Pers. (Aphyllophoromycetideae)

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