Systemic comorbidities associated with rosacea: a multicentric retrospective observational study

Abstract

Background Once considered a disorder limited to the skin, rosacea is now known to be associated with systemic disorders. The aim of this study was to determine what systemic comorbidities accompany rosacea and to determine the relationship between the type, severity, and duration of rosacea, and the presence of and type of systemic comorbidities. Methods This retrospective multicenter study was conducted by the Turkish Society of Dermatology Acne Study Group. Thirteen dermatology clinics throughout Turkey participated in the study. A structured physician‐administered questionnaire was used to collect patient demographics, clinical findings, and lifestyle data. The principal rosacea subtype, physician global assessment of severity, and duration of rosacea were recorded. Physicians recorded each participant's medical history, including current and past comorbidities, duration of any such comorbidity, and the use of medications to treat any comorbidities. Results The study included 1,195 rosacea patients and 621 controls without rosacea aged 18–85 years. As compared to the controls, more of the rosacea patients had respiratory tract, gastrointestinal system, and metabolic and hepatobiliary system disorders in a rosacea's severity‐ and duration‐dependent manner. Conclusion Clinicians must be aware of the potential for systemic comorbidities in rosacea patients, which becomes more likely as disease duration and severity increase.

Systemic Comorbidities in Korean Patients with Rosacea: Results from a Multi-Institutional Case-Control Study

“…A strong association between rosacea and metabolic disorder (i.e., diabetes mellitus and obesity) has been recognized in prior studies [ 47 , 48 ] and ours. It is postulated that systemic inflammation underlying rosacea induces structural changes of the lipoprotein, which adversely affects the lipid profile [ 49 , 50 ].…”

Potential association between rosacea and cancer: A study in a medical center in southern China

“…also suggested that rosacea may be a risk factor for breast cancer in independent epidemiological studies. A recent report in Turkish showed that rosacea was significantly associated with respiratory tract, gastrointestinal system, metabolic and hepatobiliary diseases …”

“…A recent report in Turkish showed that rosacea was significantly associated with respiratory tract, gastrointestinal system, metabolic and hepatobiliary diseases. 33 However, the association between rosacea and cancers in the Chinese population remains unclear. In this study, we conducted a cross-sectional study to examine the association between rosacea and selected cancers in a medical center in southern China, and we further explore potential related factors.…”

The skin microbiota as a link between rosacea and its systemic comorbidities

“…Because rosacea patients demonstrate a significantly higher prevalence of small intestinal bacterial overgrowth than controls, a connection between gut dysbiosis, skin dysbiosis, and the development of rosacea has been proposed . While there are many studies investigating the role of the gut microbiota in systemic disorders, studies of the skin microbiota are lacking.…”

“…Because rosacea patients demonstrate a significantly higher prevalence of small intestinal bacterial overgrowth than controls, a connection between gut dysbiosis, skin dysbiosis, and the development of rosacea has been proposed. 1 While there are many studies investigating the role of the gut microbiota in systemic disorders, studies of the skin microbiota are lacking. In our recent study of the microbiota of the facial skin in papulopustular rosacea (PPR) and erythematotelangiectatic rosacea (ETR), we identified a number of bacterial taxa that are enriched or depleted in individuals with rosacea compared to matched controls.…”