Systemic conditions associated with increased risk to develop oral squamous cell carcinoma: Systematic review and meta‐analysis

Santos, Erison Santana Dos; Pérez‐de‐Oliveira, Maria Eduarda; Normando, Ana Gabriela Costa; Gueiros, Luiz Alcino Monteiro; Rogatto, Sílvia Regina; Vargas, Pablo Agustı́n; Lopes, Márcio Ajudarte; Guerra, Eliete Neves Silva; Leme, Adriana Franco Paes; Santos‐Silva, Alan Roger

doi:10.1002/hed.27193

Cited by 6 publications

(4 citation statements)

References 154 publications

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“…For H&NC men, the differences observed between low and normal PA relevant in terms of age (69 ± 11 versus 60 ± 10; p < 0.001), handgrip strength (25.3 ± 8 versus 33 ± 7.2; p < 0.001), gait speed (0.75 ± 0.2 versus 0.95 ± 0.2; p > 0.001), phase angle (3.7 ± 0.6 versus 5.2 versus 0.5; p < 0.001), hemoglobin (12.9 ± 2 versus 14.3 ± 1.7 g/dL; p < 0.001), absolute lymphocyte count (1406 (1120-2015) versus 1739 (1311-2515); p = 0.024), albumin (4.1 ± 0.5 versus 4.3 ± 0.3; p < 0.001), and C-reactive protein (16.3 (5-27) versus 12 (3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20)(21); p = 0.022; Table 3).…”

Section: Comparison Between Low and Normal Pa In Menmentioning

confidence: 96%

“…The geographic distribution of N&NC is determined by habits considered risk factors, such as tobacco, alcohol, and betel nut consumption. Other identified risk factors are opium use; viral infections (Epstein–Barr virus, human papillomavirus, herpes simplex virus, hepatitis C virus, and even human immunodeficiency virus); radiation; occupational exposure to perchloroethylene, pesticides, asbestos, and polycyclic aromatic hydrocarbons; dietary aspects, such as high levels of nitrites; mouthwashes with alcohol derivates; and poor oral hygiene and periodontal disease [ 3 , 4 , 5 , 6 , 7 ].…”

Section: Introductionmentioning

confidence: 99%

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Phase Angle in Head and Neck Cancer: A Sex-Differential Analysis from Biological and Clinical Behavior to Health-Related Quality of Life

et al. 2023

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Head and neck cancer (H&NC) is a diverse category of tumors related to malignancies in the common aerodigestive pathway, with high metabolic rate, poor nutritional and treatment outcomes, and elevated mortality despite the best standard treatment. Herein, we focus on determining how the phase angle (PA) differs across sex as a predictor of poor prognosis, low quality-of-life (QoL) scores, and mortality in patients with head and neck cancer. This follow-up study presents a sex-differential analysis in a prospective cohort of 139 head and neck cancer patients categorized by sex as male (n = 107) and female (n = 32). Patients were compared in terms of nutritional, biochemical, and quality-of-life indicators between low and normal PA in women (<3.9° (n = 14, 43.75%) and ≥3.9°) and men (<4.5° (n = 62, 57.9%) and ≥4.5°). Our results show that most patients were in locally advanced clinical stages (women: n = 21 (65.7%); men: n = 67 (62.6%)) and that patients with low PA had a lower punctuation in parameters such as handgrip strength, four-meter walking speed, albumin, C-reactive protein (CRP), and CRP/albumin ratio (CAR), as well as the worst QoL scores in functional and symptomatic scales in both the male and female groups. A comparison between sexes revealed significant disparities; malnourishment and tumor cachexia related to an inflammatory state was more evident in the women’s group.

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Section: Comparison Between Low and Normal Pa In Menmentioning

confidence: 96%

Section: Introductionmentioning

confidence: 99%

Phase Angle in Head and Neck Cancer: A Sex-Differential Analysis from Biological and Clinical Behavior to Health-Related Quality of Life

et al. 2023

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“…The microbiota of the oral cavity changes by age, sex, and lifestyle [ 49 , 50 , 51 ] and varies according to local and systemic factors [ 52 , 53 , 54 ] and diseases [ 54 , 55 , 56 , 57 ]. Lastly, the role of chronic fungal superinfections is responsible for the detrimental conditions of oncologic patients, thus being a relevant risk factor for OSCC-related morbidity as well a risk factor for cancerogenesis itself [ 58 , 59 , 60 , 61 , 62 , 63 , 64 , 65 , 66 ].…”

Section: Introductionmentioning

confidence: 99%

Personalized Medicine in Oral Oncology: Imaging Methods and Biological Markers to Support Diagnosis of Oral Squamous Cell Carcinoma (OSCC): A Narrative Literature Review

Menditti,

Santagata,

Imola

et al. 2023

JPM

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For decades, oral squamous cell carcinoma (OSCC) has been one of the most prevalent and mortal cancers worldwide. The gold standard for OSCC diagnosis is still histopathology but this narrative multidisciplinary review has the aim to explore the literature about conventional OSCC prognostic indicators related to the pTNM stage at the diagnosis such as the depth of invasion and the lymphovascular invasion associated with distant metastasis as indicators of poor life expectancy. Despite its multifactorial nature and recognizable precursors, its diagnosis at the early stages is still challenging. We wanted to highlight the importance of the screening as a primary weapon that a stomatologist should consider, intercepting all at-risk conditions and lesions associated with OSCC and its early stages. This narrative review also overviews the most promising imaging techniques, such as CT, MRI, and US-echography, and their application related to clinical and surgical practice, but also the most-investigated prognostic and diagnostic tissue and salivary biomarkers helpful in OSCC diagnosis and prognostic assessment. Our work highlighted remarkable potential biomarkers that could have a leading role in the future. However, we are still far from defining an appropriate and concrete protocol to apply in clinical practice. The hope is that the present and future research will overcome these limitations to benefit patients, clinicians, and welfare.

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“…Oral leukoplakia (OLK) is one of the most common types of oral potentially malignant disorders (OPMDs), with a malignant transformation (MT) rate of 9.8% (95% CI: 7.9−11.7) [ 4 ]. However, sensitive non-invasive examinations to screen MT of OLK were still lacking [ 5 ].…”

Section: Introductionmentioning

confidence: 99%

Compositional and functional changes in the salivary microbiota related to oral leukoplakia and oral squamous cell carcinoma: a case control study

Lan,

Zhang,

Hua

et al. 2023

BMC Oral Health

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Background Oral squamous cell carcinoma (OSCC) is one of the most common malignant tumours with increasing incidence, and oral leukoplakia (OLK) has a strong tendency to undergo malignant transformation. The oral microbiota may influence oral cancer progression, but the salivary bacterial composition and functional changes in OSCC and OLK have not been comprehensively elucidated. Therefore, we compared salivary bacteria in OLK and OSCC patients with healthy controls (HC). Methods Metagenomic sequencing was used to compare the bacterial composition and functional changes of 18 OSCC patients, 21 OLK patients and 21 HC. Spearman correlation was used to identify possible associations between functions and bacteria. Results Gemella was the most differentially enriched genus in OSCC. At the species level, Streptococcus sp. NPS 308, Streptococcus agalactiae, Gemella haemolysans and Gemella morbillorum were slightly increased in OLK and OSCC. Kyoto Encyclopedia of Genes and Genomes (KEGG) results showed that OSCC was mainly associated with metabolism functions, including lipid metabolism, carbohydrate metabolism and glycan biosynthesis and metabolism. The synthesis and degradation of ketone bodies, cysteine and methionine metabolism and glycerolipid metabolism differed significantly among the three groups, and were highest in OSCC and lowest in HC. And G. haemolysans was significantly associated with these selected metabolic pathways. Conclusions Metagenomic analysis revealed significant differences in the salivary microbiota among OSCC, OLK and HC. Thus, salivary microbiota composition and functional changes may be associated with OSCC progression. Metabolism of nonessential amino acids such as cysteine and methionine in bacteria may play an important role in oral oncogenesis, and more studies of the mechanism between metabolisms of bacteria and oral oncogenesis are needed in the future.

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Systemic conditions associated with increased risk to develop oral squamous cell carcinoma: Systematic review and meta‐analysis

Cited by 6 publications

References 154 publications

Phase Angle in Head and Neck Cancer: A Sex-Differential Analysis from Biological and Clinical Behavior to Health-Related Quality of Life

Phase Angle in Head and Neck Cancer: A Sex-Differential Analysis from Biological and Clinical Behavior to Health-Related Quality of Life

Personalized Medicine in Oral Oncology: Imaging Methods and Biological Markers to Support Diagnosis of Oral Squamous Cell Carcinoma (OSCC): A Narrative Literature Review

Compositional and functional changes in the salivary microbiota related to oral leukoplakia and oral squamous cell carcinoma: a case control study

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