Systemic contact dermatitis from 5–fluorouracil

Allergic contact dermatitis in patients with leg ulcers

“…Contact sensitization is much more frequent in leg ulcer and stasis eczema patients than in other groups of eczematous patients (6,7,9,11,12,(14)(15)(16)(17)(18). Explanations differ (7,9,(18)(19)(20)(21). Neomycin is the most common anti- which are potent sensitizers (28).…”

“…30, 31). Balsam of Peru has varied in frequency between studies (7,16,17). The correspondingly high figure for fragrance mix warns against fragrance application to inflamed skin (32).…”

“…( 2 ) postulated several diagnostic criteria to differentiate irritant contact dermatitis from allergic contact dermatitis from 5-FU. Only scattered descriptions documented by positive patch tests have been reported (1)(2)(3)(4)(5)7). However, Epstein (3) demonstrated that l in 4 patients with 5-FU allergy will escape detection with patch tests, and require i.d.…”

Allergic contact dermatitis because of topical use of 5‐fluorouracil (Efudix® cream)

“…It usually elicits a moderate to severe irritant contact dermatitis with erythema and scaling at the site of the application, and symptoms of burning, pruritus and stinging. Although several cases have been reported in literature (1–8), allergic contact dermatitis from Efudix® cream seems to be uncommon, given its widespread use (2). To our knowledge, we are the first to report a series of 14 patients in whom an allergic contact dermatitis was suspected, and in whom the different ingredients of the cream were also patch tested.…”