Systemic effects of local allergic disease

Togias, Alkis

doi:10.1016/j.jaci.2003.09.051

Cited by 95 publications

(87 citation statements)

References 61 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…1,2 Moreover, allergic disorders such as allergic rhinitis or asthma have also been reported to be associated with atherosclerosis. 3 The coronary artery calcification (CAC) score has recently been developed as a marker of coronary atherosclerosis, which can be assessed noninvasively using multislice CT (MSCT). CAC is an established quantitative, objective measure of coronary artery atherosclerosis, and several studies have revealed a correlation between CAC and angiographic stenosis.…”

Section: Introductionmentioning

confidence: 99%

Eosinophil count is positively correlated with coronary artery calcification

Tanaka

Fukui

Tomiyasu³

et al. 2011

Hypertens Res

View full text Add to dashboard Cite

Section: Introductionmentioning

confidence: 99%

Eosinophil count is positively correlated with coronary artery calcification

Tanaka

Fukui

Tomiyasu³

et al. 2011

Hypertens Res

View full text Add to dashboard Cite

“…According to Togias, the mechanisms that lead instead to the development of the systemic element probably include intricate interactions between mediators of the acute allergic reaction, locally and systemically produced cytokines and neurotrophins, the vascular epithelium and the adhesion molecule system, the chemokine network and antigenpresenting cells and their interactions with T lymphocytes [12].…”

mentioning

confidence: 99%

Allergy as an organ and a systemic disease

Pucci

Incorvaia²

2008

Clinical and Experimental Immunology

View full text Add to dashboard Cite

SummaryAllergic disorders are viewed generally as organ diseases and thus referred to organ specialists, such as the ear, nose and throat specialist for rhinitis, the pulmonologist for asthma, the dermatologist for dermatitis, and so on. Indeed, the systemic nature of allergy is made evident by the fact that the same individual may develop during the life different manifestations to a given allergen. This is true for example in sensitisation to house dust mites, which may start in childhood as atopic dermatitis and later express as asthma or rhinitis.The major player in driving the immune response is the T lymphocyte, and the T helper subpopulations -Th1 and Th2 -as well as the T regulatory cells, are involved in orienting tolerance or reactivity to allergens. Interesting observations on the systemic or organ-specific actions of T cells were obtained by transplantations from allergic donors to non-allergic recipients. Bone marrow is able to transfer all allergic manifestations, while lung transplantation transfers only asthma. A number of factors are involved in the expression of allergy as a systemic or organ disease and deserve deeper investigations. They include the antigen presenting cells, the homing of T cells, the cytokine and chemokine pattern, and the adhesion molecules.

show abstract

“…Allergic diseases including bronchial asthma are not confined to the area where they originated but they involve also systemic circulation [21]. The present study demonstrates that BUD, an inhaled corticosteroid widely used for the management of bronchial asthma, controls asthma inflammation by modulating TLR2 and TLR4 and IL-10 expression in CD4þ/CD25highlyþ cells as well as IL-6 and TNF-a release in PBMC of asthmatics.…”

Section: Discussionmentioning

confidence: 52%